Congenital heart disease mortality in Spain during a 10 year period (2003–2012)

Picarzo, Javier Pérez-Lescure; González, Margarita Mosquera; Zamalloa, Pello Latasa; Marcos, D. Crespo

doi:10.1016/j.anpede.2017.06.003

Cited by 9 publications

(7 citation statements)

References 13 publications

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“…Recent improvements of surgical and diagnostic procedures [32][33][34] have improved the survival of patients with congenital heart diseases; however, still significant mortalities among infants associated with CHDs are observed [13,14,[35][36][37]. The mortality is higher for low birth weight infants even after surgical intervention [38].…”

Section: Introductionmentioning

confidence: 99%

Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways

Suluba

Liu

Xia

et al. 2020

Egypt J Med Hum Genet

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Background: Congenital heart diseases (CHDs) are the most common congenital anomalies with an estimated prevalence of 8 in 1000 live births. CHDs occur as a result of abnormal embryogenesis of the heart. Congenital heart diseases are associated with significant mortality and morbidity. The damage of the heart is irreversible due to a lack of regeneration potential, and usually, the patients may require surgical intervention. Studying the developmental biology of the heart is essential not only in understanding the mechanisms and pathogenesis of congenital heart diseases but also in providing us with insight towards developing new preventive and treatment methods. Main body: The etiology of congenital heart diseases is still elusive. Both genetic and environmental factors have been implicated to play a role in the pathogenesis of the diseases. Recently, cardiac transcription factors, cardiacspecific genes, and signaling pathways, which are responsible for early cardiac morphogenesis have been extensively studied in both human and animal experiments but leave much to be desired. The discovery of novel genetic methods such as next generation sequencing and chromosomal microarrays have led to further study the genes, non-coding RNAs and subtle chromosomal changes, elucidating their implications to the etiology of congenital heart diseases. Studies have also implicated non-hereditary risk factors such as rubella infection, teratogens, maternal age, diabetes mellitus, and abnormal hemodynamics in causing CHDs. These etiological factors raise questions on multifactorial etiology of CHDs. It is therefore important to endeavor in research based on finding the causes of CHDs. Finding causative factors will enable us to plan intervention strategies and mitigate the consequences associated with CHDs. This review, therefore, puts forward the genetic and non-genetic causes of congenital heart diseases. Besides, it discusses crucial signaling pathways which are involved in early cardiac morphogenesis. Consequently, we aim to consolidate our knowledge on multifactorial causes of CHDs so as to pave a way for further research regarding CHDs. Conclusion: The multifactorial etiology of congenital heart diseases gives us a challenge to explicitly establishing specific causative factors and therefore plan intervention strategies. More well-designed studies and the use of novel genetic technologies could be the way through the discovery of etiological factors implicated in the pathogenesis of congenital heart diseases.

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Section: Introductionmentioning

confidence: 99%

Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways

Suluba

Liu

Xia

et al. 2020

Egypt J Med Hum Genet

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“…On the other hand, it may be related to the fact that all data collected in this study were from neonates and infants because it has been reported 9 that the incidence of CHD may decrease with the increase of age. Previous study showed that 2,9,12,17,18 the types of diseases with high morbidity of congenital heart malformation were, in descending order of incidence, ventricular septal defect, atrial septal defect, patent ductus arteriosus, pulmonary artery stenosis, and tetralogy of Fallot. It is identical to high-incidence disease types found in this study, but the incidence of atrial septal defect and ventricular septal defect is slightly different.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological analysis of neonatal CHD near Petrochemical Complex

Chen

Huang

2019

Cardiol Young

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AbstractObjective:To study the incidence, types, and characteristics of CHD in all live births delivered in Jinshan Hospital from 1 January, 2016 to 31 December, 2017, and to analyse the correlation between CHD and the distance between maternal residence and Shanghai Petrochemical Complex.Methods:All live births, delivered in Jinshan Hospital in 2016 and 2017, have received CHD screening and neonatal follow-up after delivery. For those both positive for CHD screening and negative for CHD screening but with heart murmur found during physical examination on neonatal follow-up after delivery, echocardiography was performed to confirm CHD diagnosis. All maternal residential addresses have been grouped for analysis according to the distance between maternal residence and Shanghai Petrochemical Complex.Results:There were 5544 live births in total, and a total of 79 children with CHD were confirmed by CHD screening and echocardiography, of which the types of diseases with high incidence, in descending order of incidence, are atrial septal defect (48/79), ventricular septal defect (25/79), patent ductus arteriosus (21/79), and pulmonary artery stenosis (9/79). There was no statistically significant difference in the incidence of CHD among the groups divided by the distance between maternal residence and Shanghai Petrochemical Complex. The incidence of neonatal CHD near Shanghai Petrochemical Complex is 1.42%.Conclusions:Most of the children with CHD can be screened out through CHD screening and physical examination in neonatal period and early infancy stage. The distance between maternal residence and Shanghai Petrochemical Complex has no significant direct effect on the incidence of CHD in neonates near Shanghai Petrochemical Complex.

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“…However, it was higher than the study conducted in Europe (0.7%/1000) [52] & Spain (4.58/1000). [53], This variation might be due to the NICU physical environment difference.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Predictors of Mortality among Neonates Admitted for Congenital Heart Disease in Public Comprehensives Specialized Hospitals, Amhara Region, Ethiopia 2023

Ayfokru,

Shewasinad,

Ahmed

et al. 2023

Preprint

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BackgroundCongenital heart disease is typically defined as a structural abnormality of the heart and great vessels present at birth. The incidence and mortality of congenital heart disease in neonates vary worldwide and it is the leading cause of birth defects, morbidity and mortality.Objectiveto assess incidence and predictors of mortality among neonates admitted for congenital heart disease in public comprehensives specialized hospitals Amhara region, Ethiopia a Retrospective follow-up study 2023MethodInstitution-based retrospective follow-up study was conducted among 583 neonates with congenital heart disease admitted to Amhara region public comprehensive specialized hospitals from January 1st2018 to December 30th, 2022. The study subjects was selected using simple random sampling techniques. Data were entered into EPI data version 4.6, then exported to STATA version 16. The log-rank test and Kaplan Meier failure curve was used to estimate and compare the probability of death. First bivariable then multivariable regression was done. After computing a hazard ratio with a 95% confidence interval, variables with a p-value of 0.05 or lower was considered to be significant predictors of mortalityResultsOut of 583 congenital heart disease neonate 9.9% were developed death. The incidence rate of mortality among congenital heart disease neonates was 11.9% per 1000 with 4844 person-days of observation (95% CI;-0.009-0.015). In this study were found to be Sepsis(AHR:2.24(95%CI:-1.184.23),Cyanoticcongenital heart disease(AHR:3.49(95%CI:1.93-6.28), Home delivery(AHR:1.9(95%,CI:1.06-3.6), had maternal history of Gestational diabetes multiuse (AHR: 1.94 (95% CI 1.04-3.61). Neonates having another congenital malformations. (AHR 2.49(1.33-4.67). neonates have been Airway resuscitation needed during delivery (AHR: 0.43(95%CI: 0.18-0.98). were found to be a significant predictors of Congenital heart disease neonatal mortality.Conclusion and recommendationThe incidence rate of neonatal mortality among congenital heart disease neonate was high as compared to findings of other studies. sepsis, cyanotic congenital heart disease, home delivery, maternal history of gestational diabetes malts, others congenital malformation and Airway resuscitations needed during delivery were significant predictors of mortality for neonates with congenital heart disease. Hence, giving special attention to patients with identified predictors should be better

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Congenital heart disease mortality in Spain during a 10 year period (2003–2012)

Cited by 9 publications

References 13 publications

Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways

Congenital heart diseases: genetics, non-inherited risk factors, and signaling pathways

Epidemiological analysis of neonatal CHD near Petrochemical Complex

Incidence and Predictors of Mortality among Neonates Admitted for Congenital Heart Disease in Public Comprehensives Specialized Hospitals, Amhara Region, Ethiopia 2023

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