Congenital Heart Surgery: Analysis of 102 Cases

Alam, Akm Manzurul; Ahmed, Ishfaq; Ahmed, Manzil; Hossain, Al Mamun

doi:10.3329/bhj.v30i2.28812

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…Mollah et al found that most often children are presented by 1 years of age. 10 Hussain et al found 44.99% CHD were diagnosed during neonatal period. 19 The diagnosis in 75.43% of cases was made under one year of age, in the research conducted in Hazara.…”

Section: Discussionmentioning

confidence: 98%

“…9 According to recent update report of the American heart association, ASD, VSD, TOF, PDA, pulmonary stenosis, aortic stenosis, coarctation of aorta, and atrio VSD accounts for 85% of all CHDs. 10 Thus this study was conducted in a paediatric cardiology department of Bangladesh Shishu hospital and Institute which is a tertiary care hospital in Bangladesh with the aim to determine the current pattern of distribution of CHD in the population and age at which initial diagnosis of CHD was made.…”

Section: Introductionmentioning

confidence: 99%

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Frequency and pattern of congenital heart defects among admitted patient in a tertiary care hospital in Bangladesh

Munsi,

Sayeed,

Akter

2023

Int J Res Med Sci

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Background: Congenital heart disease (CHD) is the commonest of all congenital lesions accounting for nearly 28% of all congenital malformations that have significant impact on morbidity, mortality and heath care cost in children. The aim of study was to determine the pattern of distribution of CHD and the age at which initial diagnosis of CHD was made among children admitted under paediatric cardiology department, Bangladesh Shishu hospital and institute. Methods: This is a descriptive and prospective hospital-based study conducted in the pediatric cardiology department, Bangladesh Shishu hospital and institute. This study included all the patients admitted during January-June 2022 in pediatric cardiology department having confirmed diagnosis of CHD on basis of echocardiographic report. The collected data was entered and analyzed by using statistical package for social sciences v 24.0. Results: Out of 337 patient, 175 patient were male (51.9%) and 162 female (48.1%) with male female ratio of 1.08:1. Total 219 cases (64.9%) were acyanotic CHD and 118 (35.1%) were cyanotic congenital heart lesions. In acyanotic CHD ventricular septal defects (VSDs) constitute 38.8% followed by AV canal defect 6.7%, patent ductus arteriosus (PDA) 3.6%. In cyanotic CHD tetralogy of Fallot (TOF) was the commonest lesion accounted for 28 (8.3%) followed by d-transposition of great arteries 16 (4.7%), pulmonary atresia 15 (4.5%), total anomalous pulmonary venous circulation TAPVC 11 (3.3%), tricuspid atresia 9 (2.7%) and DORV, VSD, PS 10 (2.9%). The commonest combination was VSD with ASD in 15 cases (4.5%). Most of the patient was diagnosed in 1st year of age 280 (83.1%) Conclusions: CHD are very common in our setup and early detection of CHD is increasing. Overall burden of CHD is also increasing therefore a proper population-based study on a large scale is needed to estimate the prevalence accurately.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Frequency and pattern of congenital heart defects among admitted patient in a tertiary care hospital in Bangladesh

Munsi,

Sayeed,

Akter

2023

Int J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…Its symptoms depend on the specific type of anomaly and therefore symptoms may vary widely, ranging from none to those of life-threatening severity (2). CHD is also a major cause of infant mortality worldwide (3).…”

Section: Introductionmentioning

confidence: 99%

JNK and NF‑κB signaling pathways are involved in cytokine changes in patients with congenital heart disease prior to and after transcatheter closure

Fan

Ke-fang

Zhang³

et al. 2017

Exp Ther Med

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Congenital heart disease (CHD) is a problem in the structure of the heart that is present at birth. Due to advances in interventional cardiology, CHD may currently be without surgery. The present study aimed to explore the molecular mechanism underlying CHD. A total of 200 cases of CHD treated by transcatheter closure as well as 200 controls were retrospectively assessed. Serum cytokines prior to and after treatment were assessed by reverse-transcription quantitative polymerase chain reaction analysis. Furthermore, the levels of proteins associated with c-Jun N-terminal kinase (JNK) and nuclear factor (NF)-κB were assessed by western blot analysis and immunohistochemistry. Furthermore, an animal model of CHD in young pigs was successfully constructed and treated with inhibitors of JNK and/or NF-κB to investigate the roles of these pathways in CHD. The results revealed that tumor necrosis factor-α, interleukin (IL)-6 and IL-8 were significantly elevated in the experimental group following transcatheter closure treatment, compared with those in the healthy control group, and the serum levels of the anti-inflammatory cytokine IL-10 were significantly reduced. Phosphorylated c-Jun and p65 levels in the experimental group were notably higher in the experimental group compared with the control group, but were restored to normal levels following transcatheter closure treatment. Similar results were also obtained in the pig model. The results of the present study suggested that the CHD-associated changes in cytokines, as well as their recovery following transcatheter closure treatment were associated with the JNK and NF-κB signaling pathways. The present study may provide further understanding of the underlying molecular mechanisms in CHD and propose a potential novel target for the treatment of CHD.

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Congenital Heart Surgery: Analysis of 102 Cases

Cited by 2 publications

References 4 publications

Frequency and pattern of congenital heart defects among admitted patient in a tertiary care hospital in Bangladesh

Frequency and pattern of congenital heart defects among admitted patient in a tertiary care hospital in Bangladesh

JNK and NF‑κB signaling pathways are involved in cytokine changes in patients with congenital heart disease prior to and after transcatheter closure

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