Congenital Herpetic Keratitis

Bilateral Necrotizing Retinitis Complicating Fatal Encephalitis Probably due to Herpes Simplex Virus Type 2

“…Less frequently the infant acquires type 1 or type 2 infection soon after birth, either from its mother or some other nearby person. A u thentic records of transplacental infection are uncommon but a case of congenital ac tive keratitis due to H SV type 1 has been reported in an infant born by caesarian sec tion before rupture of the membranes [Hutchinson et al, 1975], The case reported here is an example of localized H SV type 2 infection with the main emphasis on necro tizing encephalitis and retinitis plus infec tion of the skin and oral cavity. Infection was probably acquired at some time during birth.…”

Isolated Herpes Simplex Keratoconjunctivitis in a Neonate Born by Cesarean Delivery

“…Because of the 48-to 72-hour minimal incubation time for symptomatic HSV infection, disease development within the first 48 hours after chorioamniotic membrane rupture is considered to represent congenital infection by definition, 4 which is a rare manifestation of neonatal disease, with only a few cases of congenital systemic HSV keratitis having been reported in the medical literature. 5,6 In our case, postpartum exposure leading to infection was unlikely because of to the development of overt signs of ocular infection during the first day of life. It is also implausible that maternal oral HSV-1 virus shedding was the source for the patient's HSV-2 keratoconjunctivitis, attributable to the fact that the direct immunofluorescence monoclonal antibody assay to confirm and type the herpes simplex virus isolates from the child and the mother is both highly sensitive for detection and specific for correct typing.…”

Herpetic Simplex Eye Disease in the Pediatric Population

“…5 This can be exhibited by stromal keratitis within days of birth. 6 Classification of the disease can be separated into 3 distinct categories, (1) skin, eye, and mouth (SEM), (2) central nervous system (CNS) disease, or (3) disseminated disease. The lack of skin vesicles creates a diagnostic dilemma often leading to a delay in treatment in any one of these categories.…”