Congenital Hydranencephaly/Porencephaly Due to Vascular Disruption in Monozygotic Twins

Jung, Jinkyu; Graham, John M.; Schultz, Nancy Lusignan; Smith, David W.

doi:10.1542/peds.73.4.467

Cited by 78 publications

(3 citation statements)

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“…5,17,[22][23][24] The increase in congenital anomalies in MZ twins is thought to result from the twinning process or interfetal hemodynamic complications. 36 Malformations, deformations, or disruptions can occur during the formation of an MZ twin, resulting in structural anomalies. 7 Considering that MZ twinning is inherently more likely to lead to malformations, it is plausible that there is a greater occurrence of congenital anomalies in MZ than in DZ twins or singleton pregnancies.…”

Section: Differences In Congenital Anomalies Between Monozygotic and ...mentioning

confidence: 99%

“… 17,21–24,31,34 Several studies used same-sex twins as a crude index for MZ twins 5,17,22–24 . The increase in congenital anomalies in MZ twins is thought to result from the twinning process or interfetal hemodynamic complications 36 . Malformations, deformations, or disruptions can occur during the formation of an MZ twin, resulting in structural anomalies 7 .…”

Section: Differences In Congenital Anomalies Between Monozygotic and ...mentioning

confidence: 99%

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Congenital Anomalies in Multiple Pregnancy: A Literature Review

Shin,

Ko,

Bae

et al. 2024

Obstetrical &Amp; Gynecological Survey

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Importance Multiple pregnancy is relatively common in many countries and is associated with various pregnancy complications, including preterm birth, low birth weight, and congenital anomalies. In particular, a poorer prognosis has been reported when congenital anomalies overlap with other pregnancy complications in multiple pregnancy compared with singleton pregnancy. Objective This study reviews the characteristics of congenital anomalies that occur in multiple gestations as compared with singleton pregnancies. Evidence Acquisition An extensive manual search of major electronic databases was conducted in June 2023. This literature review provides a comprehensive coverage of the congenital anomalies in multiple pregnancy. Results Most studies have shown that multiple gestations are associated with an increased risk of congenital anomalies compared with singleton pregnancies. In addition, higher rates of congenital anomalies and concordance have been observed in monozygotic versus dizygotic twins. The effect of assisted reproductive therapies on the risk of congenital anomalies appears to be smaller in multiple gestations than in singleton pregnancies. Conclusions Multiple pregnancy is significantly associated with an increased risk of congenital anomalies. Relevance This review provides obstetrical providers with the requisite knowledge to offer appropriate antenatal care and prenatal anomaly screening to patients with multiple pregnancies. Target Audience Obstetrics and gynecology specialists and family physicians. Learning Objectives After participating in this activity, the learners should be better able to explain the prevalence and trend of congenital anomalies in multiple pregnancy; describe the importance of zygosity in prevalence and concordance in multiple pregnancy; and describe the effect of assisted reproductive therapies on the risk of congenital anomalies.

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Section: Differences In Congenital Anomalies Between Monozygotic and ...mentioning

confidence: 99%

Section: Differences In Congenital Anomalies Between Monozygotic and ...mentioning

confidence: 99%

Congenital Anomalies in Multiple Pregnancy: A Literature Review

Shin,

Ko,

Bae

et al. 2024

Obstetrical &Amp; Gynecological Survey

View full text Add to dashboard Cite

show abstract

“…Enbom [14] reported that 46% of the survivors suffered major morbidity or death, although he recognized the shortcomings of his retrospective study, and the report by Szymonowicz et al [41] is even more devastating. Numerous other investigators have reported that significant neurological damage may occur in the surviving twin, and many additional case reports may be found referred to in these publications [2,9,13,20,21,23,38,44,45]. Thus, Hoyme et al [20] outlined structural defects observed in children whose monochorionic cotwin died in utero.…”

Section: Outcome Of the Surviving Twinmentioning

confidence: 99%

Intrauterine Death in Multiple Gestation

Liu

Benirschke²,

Scioscia³

et al. 1992

Acta genet. med. gemellol.: twin res.

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Intrauterine death of one fetus in a multiple gestation is associated with significant morbidity and mortality in the surviving infant. This study is a retrospective review of 38 twin and 3 triplet gestations involving the intrauterine death of at least one fetus. The obstetrical history, placental pathology, autopsy findings, and neonatal history of the surviving infant are reviewed. Three cases involved the recent stillbirth of both twins, the remaining cases involved a surviving infant. In one case, neonatal death of a surviving twin occurred on day 19. In two sets of triplets, two stillbirths occurred, in the third case two infants were liveborn. The incidence of preterm delivery was 34%, which decreased to 18% if fetal cotwin death had occurred before 20 weeks gestation. Cesarean section was the method of delivery in 16 cases. There was an excess of velamentous cord insertions, which was most pronounced in the stillborn twin. Monochorionic placentation was found in 72%, also an excess.Neurological damage was known to have occurred in 19 of the 39 surviving infants. Fifteen of these 19 (79%) were associated with monochorionic placentation. The neurologically damaged twin infants, when compared to the normal infants, had the cotwin die later in gestation (31 vs 16.5 weeks), had a shorter duration between the death of the cotwin and delivery (2.5 vs 21 weeks), and delivered earlier in gestation (36.5 vs 39.5 weeks). The probable cause of neurological damage, in our opinion, was either exsanguination into the dead twin fetus, or disseminated intravascular coagulation which occurred in at least 13 cases. The incidence of antepartum death in a multiple gestation, and the potential for neurological damage is probably higher than previously thought. A review of the literature is presented and the clinical implications of this phenomenon are discussed.

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Bilateral porencephaly, cerebellar hypoplasia, and internal malformations: Two siblings representing a probably new autosomal recessive entity

Bönnemann

Meinecke

1996

Am. J. Med. Genet.

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We report on 2 sibs with bilateral porencephaly, absence of the septum pellucidum, and pancerebellar hypoplasia including absence of the vermis. Situs inversus and tetralogy of Fallot was present in one, and an atrial septal defect in the other. This constellation of findings is discussed against the background of familial porencephalies and schizencephalies, familial cerebellar hypoplasias, and asplenia/polysplenia syndromes. It is concluded that the described constellation of findings constitutes a new entity of probably autosomal recessive inheritance. © 1996 Wiley‐Liss, Inc.

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Congenital Hydranencephaly/Porencephaly Due to Vascular Disruption in Monozygotic Twins

Cited by 78 publications

References 0 publications

Congenital Anomalies in Multiple Pregnancy: A Literature Review

Congenital Anomalies in Multiple Pregnancy: A Literature Review

Intrauterine Death in Multiple Gestation

Bilateral porencephaly, cerebellar hypoplasia, and internal malformations: Two siblings representing a probably new autosomal recessive entity

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