Congenital Hypofibrinogenaemia and Recurrent Abortion

Hahn, Lennart; Lundberg, Per‐Arne; Teger‐Nilsson, Ann‐Catrine

doi:10.1111/j.1471-0528.1978.tb15605.x

Cited by 22 publications

(15 citation statements)

References 11 publications

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“…Hahn [9] reported 6 spontaneous abortions, all in the first trimester in a patient with con genital hypofibrinogenaemia and postu lated that the mothers' fibrinogen plays a role in the maintenance of early pregnan cy. In contrast, the mother of our proposi ta had 2 abortions in the second trimester.…”

Section: Discussionmentioning

confidence: 99%

Congenital Afibrinogenaemia in a Saudi Family: A Case Report and Family Study

Elseed¹,

Karrar²

1984

Acta Haematol

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Section: Discussionmentioning

confidence: 99%

Congenital Afibrinogenaemia in a Saudi Family: A Case Report and Family Study

Elseed¹,

Karrar²

1984

Acta Haematol

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“…It has been reported that from a clini cal point of view, a large number of the preg nant women suffering from congenital hypo fibrinogenemia and dysfibrinogenemia show severe obstetric complications, especially in the first and second trimesters of pregnancy, such as recurrent abortion [1,2] and placen tal abruptio [3,4], These clinical data sup port the hypothesis that fibrinogen is essen tial to maintain permanent and effective pla cental insertion in the uterine decidua. How ever, the minimum level of this protein which has to be present in plasma in order for the placenta to adhere to the uterus throughout pregnancy is still unclear.…”

Section: Introductionmentioning

confidence: 72%

Congenital Hypofibrinogenemia and Pregnancy, Obstetric and Hematological Management

Gilabert

Regañón²,

Vila³

et al. 1987

Gynecol Obstet Invest

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A 27-year-old pregnant woman with severe congenital hypofibrinogenemia was studied from the 18th to the 40th week of pregnancy, after which she had a normal delivery. The results of the quantitative and qualitative fibrinogen studies done on the patient made it possible to rule out associated dysfibrinogenemia. No variations in the concentration and function of fibrinogen were observed during gestation. The only treatment given was a transfusion of fresh plasma prior to delivery. The importance of fibrinogen in maintaining normal placental insertion and the obstetric management of predelivery and delivery are discussed.

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“…Recurrent abortion [12,13] and recurrent placental abruption [11,14] and postpartum hemorrhage [11,[14][15][16][17][18][19][20] have been reported in cases with congenital hypofibrinogenemia. Goodwin [22] reviewed congenital hypofibrinogenemia in pregnancy in the last 30 years.…”

Section: Resultsmentioning

confidence: 99%

Congenital Afibrinogenemia with Successful Delivery

Kobayashi

Asahina

Maehara

et al. 1996

Gynecol Obstet Invest

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We experienced a case of congenital afibrinogenemia and successfully performed cesarean section with administration of fibrinogen. The patient was administered fibrinogen every week to sustain a fibrinogen level above 60 mg/ dl according to our previously reported first case. Pregnancy course was uneventful, and fetal growth was normal, but unfortunately placental abruption occurred after the spontaneous onset of labor at 37 weeks gestation. The fibrinogen level before labor was 96 mg/dl, but decreased to 33 mg/dl when placental abruption was diagnosed. During and after the operation, it was increased to 147 and 199 mg/dl, respectively, through infusion of 10 g of fibrinogen, and massive bleeding was stopped. Two grams of fibrinogen were infused daily after cesarean section, and postpartum hemorrhage was normal. It is obvious that fibrinogen is an extremely important factor in maintaining pregnancy, and we conclude that fibrinogen level must be at least 60 mg/dl during pregnancy, 120 mg/dl during surgery and 150 mg/dl during labor, if possible as high as 200 mg/dl, under the continuous infusion of fibrinogen to prevent placental abruption.

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Congenital Hypofibrinogenaemia and Recurrent Abortion

Abstract: Summary A 26‐year‐old patient, who had had six consecutive spontaneous early abortions, is presented. The patient had hypofibrinogenaemia. The importance of a normal fibrin network in early pregnancy is discussed.

Cited by 22 publications

References 11 publications

Congenital Afibrinogenaemia in a Saudi Family: A Case Report and Family Study

Congenital Afibrinogenaemia in a Saudi Family: A Case Report and Family Study

Congenital Hypofibrinogenemia and Pregnancy, Obstetric and Hematological Management

Congenital Afibrinogenemia with Successful Delivery

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