Congenital Hypopituitarism and Conjugated Hyperbilirubinemia in Two Infants

Abstract

Parenteral alimentation is invaluable in salvaging infants who otherwise would have been unable to survive congenital anomalies of the intestine or necrotizing enterocolitis.1 A catastrophe complicated an infant's recovery from bowel resection and intolerance to oral feeding.

Investigation and outcome of neonatal hepatitis in infants with hypopituitarism

“…Twelve infants (5M, 7F) with a median age of 7 wk (range [3][4][5][6][7][8][9][10][11][12] presented to the Liver Unit at the Children's Hospital in Birmingham between 1989 and 1998 for investigation of prolonged neonatal jaundice (Table 1). All were full-term normal deliveries following an uncomplicated pregnancy except Case 1, delivered by emergency caesarean section for foetal distress following a placental abruption.…”

Congenital hypothalamic hamartoblastoma, hypopituitarism, imperforate anus, and postaxial polydactyly—a new syndrome? Part I: Clinical, causal, and pathogenetic considerations

“…In other conditions such as anencephaly and congenital absence of the pituitary gland [Lanes et al, 1978;Rimoin and Schimke, 1971;Sipponen et al, 19781, maldevelopment of the pituitary gland is known to be associated with hypoadrenalism (neonatal Addison disease and death), underdeveloped thyroid, and abnormal genital development. Thus, the microphallus in Patients, 1, 2,4, and 5 may be considered a tertiary effect of the CNS tumor.…”

Dose Adjustments of Hydrocortisone and L-thyroxine in Hypopituitarism Associated with Cholestasis

“…At least thirty-two cases of congenital hypopituitarism with cholestasis have been reported (2,3,4,5,6,7,8,9,10,11,12,13,14,15). The doses of replacement therapy were mentioned in 11 cases (3, 5, 7, 8, 10, 11). Relatively high doses of L-thyroxine (8 to 10 μg/kg/day) were needed until six months of age in five cases.…”