Congenital hypopituitarism with hypoplasia of the anterior pituitary gland and a normal posterior pituitary lobe

Kato, Fuminori; Kikuchi, Kiyoshi; Miyamoto, Satomi; Ohie, Takaharu; Yamaguchi, Seiji

doi:10.1111/j.1651-2227.1995.tb13527.x

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1995

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Cited by 5 publications

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“…At least thirty-two cases of congenital hypopituitarism with cholestasis have been reported (2,3,4,5,6,7,8,9,10,11,12,13,14,15). The doses of replacement therapy were mentioned in 11 cases (3, 5, 7, 8, 10, 11).…”

Section: Discussionmentioning

confidence: 99%

Dose Adjustments of Hydrocortisone and L-thyroxine in Hypopituitarism Associated with Cholestasis

Higuchi

Hasegawa

2006

Clin Pediatr Endocrinol

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A patient with congenital hypopituitarism associated with cholestasis is reported here. Large doses of fat-soluble hormones (hydrocortisone (20 mg/m2/day) and L-thyroxine (14 μg/kg/day)) were needed to resolve hypoglycemia and hypothyroidism during cholestasis. The doses could be reduced to 10 mg/m2/day and 3.5 μg/kg/day, respectively, after improvement of cholestasis. Sodium valproate, which is a water-soluble drug, did not need any dose adjustments during cholestasis. Adjustment of fat-soluble hormone doses during cholestasis should be considered in patients with cholestasis.

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