Congenital hypothyroidism and neonatal jaundice.

Weldon, A.; Danks, D. M.

doi:10.1136/adc.47.253.469

Cited by 21 publications

(8 citation statements)

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“…(33) Furthermore, neonates with Down syndrome or congenital hypothyroidism may develop NH beyond the age of physiological jaundice. (34,35) Our study also found gastrointestinal tract obstruction was a contributor to NH. It's well known that a lower gastrointestinal tract obstruction increases the absorption of bilirubin.…”

Section: Discussionsupporting

confidence: 67%

Etiological analyses of marked neonatal hyperbilirubinemia in a single institution in Taiwan

Cheng¹,

Chiu²,

Weng³

2012

Biomed J

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Background: Hyperbilirubinemia is a common disorder during the neonatal period. Severe neonatal hyperbilirubinemia (NH) carries a potential for permanent neurological impairment. The current study analyzed possible etiologies leading to NH. Methods:A retrospective cohort of neonates with total serum bilirubin (TSB) ≥ 20 mg/dL was surveyed from 1995 to 2007. Subjects with gestational ages < 34 weeks were excluded, leaving a total of 413 enrolled neonates. Results:The most common etiology in relation to marked NH was breast milk feeding (38.5%), followed by glucose-6-phospahate dehydrogenase (G6PD) deficiency (24.0%), ABO incompatibility (21.8%), extravascular hemorrhage (6.5%), Rh incompatibility (2.9%), bacterial infection (2.2%), hereditary spherocytosis (1.2%), dehydration (1.2%), diabetic mother (1.0%), polycythemia (0.7%), and gastrointestinal obstruction (0.7%). Other rare etiologies included Down syndrome, Chinese herb intake, asphyxia, galactosemia and congenital hypothyroidism. We did not identify any known cause in 63 neonates (15.3%). Neonates with more than one etiology tended to have higher TSB than subjects without a known etiology (p < 0.05). Anemia was more common in those with G6PD deficiency, blood group incompatibility, hereditary spherocytosis, and gastrointestinal obstruction. Neonates fed breast milk tended to have prolonged NH. Conclusion: This study depicts the clinical features of marked NH. Breast milk feeding, G6PD deficiency and ABO incompatibility are common etiologies in Taiwan. Prolonged NH is more common in neonates fed breast milk than those who were given formula.

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Section: Discussionsupporting

confidence: 67%

Etiological analyses of marked neonatal hyperbilirubinemia in a single institution in Taiwan

Cheng¹,

Chiu²,

Weng³

2012

Biomed J

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“…16 Studies have stated that hypothyroidism as one of the aetiologies in severe hyperbilirubinemia and prolonged jaundice. 5,6,7 In our study we have observed that thyroid hormone levels (T3, T4) are decreased in neonates having severe hyperbilirubinemia, but no significant correlation is noted.…”

Section: Discussionmentioning

confidence: 45%

“…17 Decreased hormone levels can cause prolonged unconjugated hyperbilirubinemia and appears to be associated with the delayed maturation of hepatic uridine diphosphate glucuronyl transferase (UDPG-T) enzyme activity. 6,7 It is also observed that the decrease of thyroid hormones in case of hyperbilirubinemia is due to alterations of thyroid hormone metabolism in cases of unconjugated hyperbilirubinemia. These effects might involve inhibition of thyroid hormone uptake by their target cells.…”

Section: Discussionmentioning

confidence: 99%

“…4 Prolonged jaundice can be associated with congenital hypothyroidism, which appears to be associated with the delayed maturation of hepatic uridine diphosphate glucuronyl transferase enzyme activity. 5,6,7 Prolonged jaundice is seen in approximately 10% of new-borns with hypothyroidism. 8 Hypothyroidism has been reported in studies, as the aetiology of jaundice that develops within the first week of life.…”

mentioning

confidence: 99%

“…8 Hypothyroidism has been reported in studies, as the aetiology of jaundice that develops within the first week of life. 6,9 The causes of pathological jaundice include haemolysis, breast milk jaundice, hypothyroidism, infections and extrahepatic biliary atresia.…”

mentioning

confidence: 99%

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