Congenital Hypothyroidism in Kuwait

Daoud, Azhar S.; Zaki, Mohammed; al-Saleh, Q A; Teebi, A. S.; Al-Awadi, S A

doi:10.1093/tropej/35.6.312

Cited by 6 publications

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“…The prevalence we found was closer to that found in China (1/5450), 3 Hungary (1/5470), 4 Moravia and Bohemia (1/5059; 1/5700) 5 and Slovakia (1/6874). 6 It was lower than the prevalence in Pakistan (1/1000), 7 North America (1/4254), 8 Switzerland (1/3000), 9 Kuwait (1/3476), 10 Ireland (1/4012) 11 and higher than the prevalence in Denmark (1/6064) 12 and Sweden (1/6900). 13 The prevalence of dyshormonogenesis we found was 1/7592 births.…”

Section: Discussionmentioning

confidence: 91%

Congenital Hypothyroidism Screening Program: A Five-Year Experience at Saudi Aramco Al Hasa Health Center

Narchi

Kulaylat²

1996

Ann Saudi Med

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We report the results of a five-year study of cord blood screening for congenital hypothyroidism in a genetically homogeneous population in the Eastern Province of Saudi Arabia. The prevalence of congenital hypothyroidism was 1/5061 and is compared to other reports. The prevalence of dyshormonogenesis was 1/7592, higher than in other reports. Ann Saudi Med 1996;16(1):47-49. HH Narchi, NA Kulaylat, Congenital Hypothyroidism Screening Program: A Five-Year Experience at Saudi Aramco Al Hasa Health Center. 1996; 16(1): 47-49 Detection of congenital hypothyroidism by neonatal screening programs has been extensively studied in developed countries. Its prevalence shows marked geographical and racial variations. We report our experience over a five-year period in the neonatal screening program for hypothyroidism, undertaken at Saudi Aramco Al Hasa Health Center between 1988 and 1992. Material and MethodsAll infants born at Saudi Aramco Al Hasa Health Center between January 1988 and the end of December 1992 were screened for congenital hypothyroidism. Our facility provides medical care for family members of Saudi Arab Aramco employees living in the Al Hasa area of the Eastern Province of Saudi Arabia. This population is genetically homogeneous and the prevalence of diseases can readily be compared with any other population.Cord blood samples were collected from the placental side at birth and were assayed for thyroxine (T4) levels by Fluorescent Polarization Immunoassay (Abbott Laboratories, Illinois, USA). For infants born outside our facility, the test was carried out on blood spot on filter paper simultaneously with PKU testing at their first visit to our facility, usually within a few days of birth. Cord blood T 4 values below 6.0 μg/dL (>2 SD below the mean for this population) were considered abnormal and cord blood thyrotropin (TSH) was measured by Microparticle Enzyme Immunoassay (Abbott Laboratories, Illinois, USA) on the same blood sample. All infants with low T 4 levels were called for clinical evaluation and had a repeat venous blood T 4 , TSH and free T 4 estimation. The lower limits (>2 SD) of repeat serum levels were defined as T 4 6.1 μg/dL, TSH 7.5 μU/mL and free T 4 0.78 ng/dL. Infants with low T 4 and high TSH were considered to have primary hypothyroidism, those with low T 4 and low TSH were considered to have secondary or tertiary hypothyroidism, while those with low T 4 accompanied with normal TSH (and normal free T 4 ) were considered to have thyroxine-binding globulin (TBG) deficiency, either congenital or acquired.The infants with confirmed hypothyroidism were started on treatment, then referred to a pediatric endocrinologist. A T 3 withdrawal test and technetium-99m pertechnetate thyroid scintigraphy are carried out after the age of three years to confirm the persistence and type of hypothyroidism. ResultsBetween January 1988 and December 1992, a total of 15,185 Saudi Arab neonates were screened for congenital hypothyroidism. A total of 363 infants had initial low T 4 values (2.39% of all ...

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Section: Discussionmentioning

confidence: 91%

Congenital Hypothyroidism Screening Program: A Five-Year Experience at Saudi Aramco Al Hasa Health Center

Narchi

Kulaylat²

1996

Ann Saudi Med

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“…[3132] However, a few studies have shown no significant relationship between consanguinity and CH. [33]…”

Section: Reviewmentioning

confidence: 99%

High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role?

2012

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Background:Despite elimination of iodine deficiency, the rates of both permanent and transient congenital hypothyroidism (CH) in our study were higher than the comparable worldwide rates, which emphasize the major role of genetic factors in the pathogenesis of CH and many studies in this regard confirm this possibility.Materials and Methods:In this review, we report all studies that established during CH screening program regarding familial and genetic component of the disease.Results:Although we could not entirely ignore the possible role of environmental and autoimmune factors in the development and function of thyroid gland, our findings strongly suggest the role of genetic factors as dominant etiologic factor in CH.Conclusion:The studies support the existence of a familial component of CH involving dominant genetic predisposition factors with a low penetrance. Considering the polygenic/multifactorial basis of CH, they suggest the possible involvement of other unknown genes in the pathogenesis of the disease, which may also follow non-Mendelian pattern of inheritance.

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Genetic Disorders in Kuwait

Makhseed

2010

Genetic Disorders Among Arab Populations

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Congenital Hypothyroidism in Kuwait

Cited by 6 publications

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Congenital Hypothyroidism Screening Program: A Five-Year Experience at Saudi Aramco Al Hasa Health Center

Congenital Hypothyroidism Screening Program: A Five-Year Experience at Saudi Aramco Al Hasa Health Center

High prevalence of congenital hypothyroidism in Isfahan: Do familial components have a role?

Genetic Disorders in Kuwait

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