Congenital Hypothyroidism in Neonates of a Tertiary Care Hospital

Abstract

Objective:To determine neonatal congenital hypothyroidism among neonates born in a tertiary care hospital of Lahore Pakistan.Methods:This cross-sectional study was carried out at Pathology Department of Allama Iqbal Medical College, Lahore in collaboration with Pediatrics and Gynecology & Obstetrics Department, Jinnah Hospital, Lahore Pakistan. A total of 770 babies were included in this study, both male and female. About 2 ml venous blood samples were collected aseptically from the neonates in sterile clotted tube. Serum was separated and serum TSH was determined by ELISA method.Results:Out of total 770 neonates, 48.9% were female and 51.0% were males with the ratio of 1:1.04. Neonatal congenital hypothyroidisim (TSH, >30 mIU/L), was observed in 0.4% (Frequency, 1:257) nenates, with the incidence rate of 1:257. Female to male ratio of hypothyroid neonates was 2:1. The mode of delivery vise distribution showed, among n=251 neonates born by normal delivery, only a single case of hypothyroidism was detected, and among n=519 neonates delivered by cesarean section, only two neonates were belong to hypothyroidism.Conclusion:The frequency of Congenital Hypothyroidism is notably higher in pediatric community than reported in most other countries. This result emphasizes the necessity of a nationwide screening program.

Post-Partum Uterine Prolapse in a Non-Descript Buffalo: Case Report

“…In most cases, it occurs immediately after parturition or occasionally up to several hours afterward and rare cases, it may occur 48 to 72 hours after parturition [4,5]. Samad et al [6] reported an incidence of 11% for buffaloes affected with postpartum uterine prolapse. In ruminants, the uterine prolapse is generally a complete inversion of the gravid cornua with incidence 0.3 to 0.5% of all calvings [7].…”

Higher frequency of Congenital Hypothyroidism among Newborns, District Dera Ghazi Khan-Punjab, Pakistan: A case control study

“…15 Ahamd et al reported incidence of congenital hypothyroidism among neonates of Lahore city and reported serum TSH cut off values were more than 30 mIU/l, to label a case of congenital neonatal hypothyroidism. 16 Researchers reported three different TSH values for diagnosis of congenital hypothyroidism. No reference TSH up to date cut off value was available.…”

“…No reference TSH up to date cut off value was available. [14][15][16] Our study was conducted to establish a reference TSH cut off value for Pakistani population from a district of Southern Punjab and for estimation of frequency of congenital neonatal hypothyroidism. Our study also estimated serum total T4 reference values of our neonatal population for diagnosis of case congenital hypothyroidism which was first time in Pakistan.…”

“…15 Ahamd et al reported incidence of congenital hypothyroidism among neonates of Lahore city and reported serum TSH cut off values were more than 30 mIU/l, to label a case of congenital neonatal hypothyroidism. 16 …”

Pediatric Quality of Life in Congenital Hypothyroidism: an Indonesian Study

“…4,5) The prevalence of CH is 1:4500 infants in the US, 1:3000 infants in Europe, 1:800 infants in Japan, 12,6:1000 infants in Iran, and 1:257 in Pakistan. [6][7][8] Newborn screening for hypothyroidism was passed by the Ministry of Health Republic of Indonesia in 2014 (PMK No. 78/2014), 9) and 1:3000 infants was diagnosed with CH.…”