Congenital infantile fibrosarcoma of the forearm

Mnif, H.; Zrig, M.; Maazoun, K.; Sahnoun, L.; Bannour, Sana; Koubaa, M.; Nouri, Anass; Abid, A.

doi:10.1016/j.main.2011.01.018

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…Radiology studies have shown poor discrimination between highly vascularized malignant soft tissue lesions and benign vascular proliferations [13]. This fact is also illustrated by our case as well as by prior reports [1–10,Table 1], in which the radiologic techniques commonly detected a mass with prominent vessels, sometimes with a cystic, hemorrhagic appearance similar to that seen in our case [1,8] and could not establish the correct diagnosis, misinterpreting the tumor as being a benign vascular proliferation. The upper extremities (including the shoulder/axillary region) seemed to be the most common location in these cases.…”

Section: Discussion and Literature Reviewsupporting

confidence: 54%

“…It has been reported [12] to be misdiagnosed as teratoma. However, the most frequently reported clinical masquerader of infantile fibrosarcoma is a vascular proliferation, in particular hemangioma [1–11], with only one other case being clinically misinterpreted as vascular malformation [7]. Moreover, infantile fibrosarcoma can present with massive bleeding from the tumor and a clinical picture of Kasabach-Merrit syndrome [1,4,8], creating confusion with a kaposiform hemangioendothelioma [8].…”

Section: Discussion and Literature Reviewmentioning

confidence: 99%

“…Sometimes a prominent vascular component is present within the tumor. In these cases, the mass could be clinically interpreted as a vascular lesion, in particular congenital hemangioma [1–11]. Herein we present a case of infantile fibrosarcoma misinterpreted clinically and radiologically as a vascular malformation.…”

Section: Introductionmentioning

confidence: 99%

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Infantile Fibrosarcoma—A Clinical and Histologic Mimicker of Vascular Malformations: Case Report and Review of the Literature

Chou

Jennings

et al. 2013

Pediatr Dev Pathol

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Infantile fibrosarcoma is a rare soft tissue tumor that usually presents either at birth or in the 1st year of life. Here we describe a case of a 4-month-old female who presented with a congenital right axillary mass. The initial clinical impression was benign vascular/lymphatic malformation. The core biopsy showed a spindle cell lesion with abundant vasculature represented by small vascular channels. However, immunohistochemical analysis did not support a diagnosis of vascular lesion/tumor. Polymerase chain reaction study for ETS Translocation Variant 6/neurotrophic tyrosine kinase receptor, type 3 fusion transcript was positive, and the diagnosis of infantile fibrosarcoma was established. The patient underwent resection of the axillary mass. Microscopic examination of the resection specimen showed numerous vascular channels. Intermixed there were also cellular areas composed of spindle cells similar to those seen in the biopsy material. Molecular studies were repeated and confirmed the diagnosis of infantile fibrosarcoma. Infantile fibrosarcoma has been previously reported in the literature to clinically masquerade as hemangioma. In addition, this case proves that infantile fibrosarcoma could also mimic vascular malformations on clinical, radiologic, and pathologic exams. In fact, the vascular component of the tumor is very unusual in our patient and represents a histologic feature that has not been described before. The case highlights the diagnostic challenges at clinical, radiologic, and pathologic levels in some cases of infantile fibrosarcoma and raises awareness among clinicians and pathologists related to another peculiar pattern that can be encountered in this disease.

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Section: Discussion and Literature Reviewsupporting

confidence: 54%

Section: Discussion and Literature Reviewmentioning

confidence: 99%

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Infantile Fibrosarcoma—A Clinical and Histologic Mimicker of Vascular Malformations: Case Report and Review of the Literature

Chou

Jennings

et al. 2013

Pediatr Dev Pathol

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“…In our study, male to female ratio is 3:1. CIFS most frequently affects the extremities and less commonly affects the trunk, head and neck, mesentery, and retroperitoneum [ 4 , 6 ]. In our study, the tumor involved the extremities in all cases (100%).…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Features of Congenital Infantile Fibrosarcoma

AlQatie,

Abbod,

Alzaid

et al. 2024

Cureus

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Background Congenital/infantile fibrosarcoma is a rare soft tissue tumor presented in early age of life. It should be considered in the differential diagnosis of the large soft tissue masses especially in the extremities at the age of infancy. These tumors frequently are misdiagnosed at birth as hemangioma. Histologically, they can resemble their adult counterparts and they are characterized by the chromosomal translocation t(12;15) (p13;q25) resulting in the ETV6-NTRK3 gene fusion. Objective A retrospective review of the MRI features of histopathology-proven congenital/infantile fibrosarcoma provides our own institutional experience and supports the limited radiology literature written about this disease. Material and method The list of our patients is obtained after reviewing our radiology and pathology database in the period between June 1st, 2007 and May 31st, 2017 (10 years) at King Faisal Specialist Hospital & Research Center, Riyadh. Phrases used to search in our MRI examinations database are: congenital infantile fibrosarcoma, infantile fibrosarcoma, juvenile fibrosarcoma, soft tissue sarcoma, malignant soft tissue mass, sarcomatous soft tissue mass, fibrosarcoma, spindle cell sarcoma, myomatous sarcoma. Result In our database and picture archiving and communication system (PACS) during the period of the study, the word (fibrosarcoma) was mentioned in the radiology report of 182 patients. Only four cases were histopathologically proven to be a congenital/infantile fibrosarcoma and had completed their own MR exams - three of them were primary/new cases, males with an age range between 0 days and 5 months (median age: 5 months). The fourth case was a female with a history of 1 st presentation at the age of one month and proved by histopathology examination but there was no available imaging at that time; however, tumor recurrence in the same patient was at the age of 4 years with available MR imaging and pathology sample. Conclusion Congenital infantile fibrosarcoma is a rare entity that has no specific MRI findings. However, it should be always considered as part of the differential diagnosis of congenital soft tissue masses with aggressive behavior.

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“…It may present as a smooth, well‐defined, and soft mass akin to a vascular malformation 34 . Alternatively, unlike a vascular malformation, it may present as a hard soft tissue mass with ulceration and necrosis 35 . Aggressive physical exam findings, if present, and the propensity of this lesion to grow rapidly should serve as diagnostic clues for alternative diagnosis.…”

Section: Image‐guided Biopsymentioning

confidence: 99%

An overview of interventional radiology techniques for the diagnosis and management of vascular anomalies: Part 2

Scollan

Azimov

Garzon

et al. 2023

Pediatric Dermatology

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Minimally invasive percutaneous and endovascular strategies performed by interventional radiologists have become the mainstays of treatment for vascular anomalies with improved outcomes, decreased complication rates, and less morbidity. The aim of this article is to introduce physicians who care for patients with vascular anomalies to state‐of‐the‐art advancements in interventional radiology for diagnosis and treatment. Part 2 of this review discusses embolization, endovenous laser ablation, and image‐guided percutaneous biopsy. Please see Part 1 for a discussion of sclerotherapy and cryoablation. Select vascular anomalies will be discussed as examples to highlight IR diagnostic and/or treatment techniques.

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Congenital infantile fibrosarcoma of the forearm

Cited by 8 publications

References 11 publications

Infantile Fibrosarcoma—A Clinical and Histologic Mimicker of Vascular Malformations: Case Report and Review of the Literature

Infantile Fibrosarcoma—A Clinical and Histologic Mimicker of Vascular Malformations: Case Report and Review of the Literature

Magnetic Resonance Imaging Features of Congenital Infantile Fibrosarcoma

An overview of interventional radiology techniques for the diagnosis and management of vascular anomalies: Part 2

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