Congenital Leukemia Presenting as Fever in a Neonate

Beard, Bethany; Turner, Jonathan S.

doi:10.1016/j.jemermed.2015.01.011

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Initial symptoms that raised the attention of the physician and parents included cutaneous lesions (most common), hepatosplenomegaly, pallor, jaundice, epistaxis, nephromegaly, intracranial hemorrhage, fever, and abnormal PB counts. 8–61 Prenatal findings suggesting potential abnormalities included hydramnios and organ masses; 8…”

Section: Resultsmentioning

confidence: 99%

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

et al. 2019

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Congenital leukemia (CL), defined as manifestations of leukemia within the first 4 weeks of life, is a rare condition with an estimated incidence of only 1 to 5 per million live births. Despite extensive research and the clinical application of new therapies, the prognosis of CL remains poor. Few large-scale studies have investigated the factors affecting the outcomes of infants with CL. Here, we conducted a retrospective study and analysis of CL cases published in the English language from 1 January 2001 to 1 May 2016. Our goal was to provide updated information about this rare disease and to investigate factors that may affect the outcomes of patients with CL.

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Section: Resultsmentioning

confidence: 99%

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

et al. 2019

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Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study

Knez

Liu

Schowinsky

et al. 2018

Leukemia & Lymphoma

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Acute lymphoblastic leukemia (ALL) in infants <1-year-old is biologically different from ALL in older children. Although KMT2A rearrangement is the predominant genetic signature in infantile B-ALL, disease course is heterogenous, behaving more aggressively in younger infants. We investigated clinicopathological differences throughout the first year to understand the transition to pediatric B-ALL. In a multi-institutional review involving four medical institutions, 54 cases of infantile B-ALL were identified. Patients were divided into congenital and non-congenital groups with multiple age subgroups. Male predominance was seen in congenital cases compared to female in non-congenital cases. There were decreasing trends of hyperleukocytosis, central nervous system involvement, KMT2A rearrangements, lineage switch, and mortality, versus increasing trends of CD10 expression and non-KMT2A abnormalities. Statistically significant differences emerged at 3 and 9 months, the latter was not previously described. Poor-prognostic risk factors decreased with age, the last trimester of infantile B-ALL essentially merging with pediatric B-ALL.

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Neonatal Acute Lymphoblastic Leukemia

et al. 2020

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Acute lymphoblastic leukemia (ALL) in a neonate can have a similar clinical appearance to other serious pathology and should be considered in the ill-appearing infant. We present the case of a 24-hour-old male infant born to a mother with limited prenatal care who was brought to the pediatric emergency department with a rash and decreased movement. His initial white blood cell count was 822 × 109 cells/L. Cytogenetics showed a complex t (9;19;11) translocation, indicating a diagnosis of neonatal ALL. Given the morbidity and mortality rate among infants with neonatal ALL, his parents elected not to pursue cancer-directed therapy in favor of symptomatic care.

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Congenital Leukemia Presenting as Fever in a Neonate

Abstract: Background: Emergency department workup of pediatric fever typically focuses on ruling out

Cited by 3 publications

References 14 publications

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

Analysis of 59 cases of congenital leukemia reported between 2001 and 2016

Clinicopathologic and genetic spectrum of infantile B-lymphoblastic leukemia: a multi-institutional study

Neonatal Acute Lymphoblastic Leukemia

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