Congenital lymphangiomatosis and an enteric duplication cyst in a young dog

Oui, Heejin; Lamm, Catherine G.; Stiver, Shane; Williams, Bruce H.; Kwon, Seong; Bae, Yeonho; Jeon, Sunghoon; Park, Seungjo; Min, Jung‐Joon; Choi, Jihye

doi:10.1111/jsap.12208

Cited by 13 publications

(13 citation statements)

References 18 publications

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“…Advanced imaging is often required for diagnosis of alimentary duplications, and diagnostic ultrasonographic findings including a double wall sign, a hypoechoic muscularis layer, and a hyperechoic mucosal layer have been reported . A recent report of concurrent lymphangiomatosis and an enteric duplication cyst in a young dog described distinct characteristics of the enteric cyst on different imaging modalities including a thick wall, mild rim enhancement, and a shared blood supply with the duodenum found on CT . The enteric cyst reported here displayed some of these reported imaging characteristics including a layered wall on ultrasound and rim‐enhancement on CT, however a shared blood supply with the duodenum was not identified with imaging.…”

Section: Discussionmentioning

confidence: 59%

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Multimodality characterization of a noncommunicating congenital duodenal duplication cyst causing pyloric outflow obstruction in a young dog

Mutascio

Grosso

Ramos‐Vara

et al. 2017

Vet Radiology Ultrasound

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A 10-month-old German Shepherd Dog presented for evaluation of intermittent vomiting. Abdominal radiographs revealed a marked right cranial mass effect. Initial differentials included abscess/cyst or less likely neoplasia from undetermined origin. On abdominal ultrasound the mass appeared cystic and thin walled. Computed tomography revealed a large cystic lesion originating from the pyloroduodenal junction causing pyloric outflow obstruction. A noncommunicating duodenal duplication cyst was found on exploratory laparotomy and further confirmed with histopathology and immunohistochemistry. Enteric duplication cyst should be considered as a differential in young dogs with gastrointestinal signs and a cystic abdominal mass detected with different imaging modalities.

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Section: Discussionmentioning

confidence: 59%

“…Duplication of the alimentary tract is an uncommon malformation suspected to be of congenital origin and has been reported in humans, dogs, cats, and horses . Duplications can be communicating or noncommunicating with the alimentary tract lumen, tubular, or spherical in structure, and can occur anywhere from the esophagus to the anus.…”

Section: Discussionmentioning

confidence: 99%

Multimodality characterization of a noncommunicating congenital duodenal duplication cyst causing pyloric outflow obstruction in a young dog

Mutascio

Grosso

Ramos‐Vara

et al. 2017

Vet Radiology Ultrasound

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“…; Oui et al . ). In horses, single cases of cutaneous lymphangioma have been described (Platt ; Gehlen and Wohlsein ), but diagnosis of intra‐abdominal lesions is limited to one 6‐month‐old colt on post‐mortem examination (Turk et al .…”

Section: Introductionmentioning

confidence: 97%

Intra‐abdominal cystic lymphangiomatosis in a Thoroughbred foal

Savage¹,

Cudmore²,

Russell³

et al. 2016

Equine Veterinary Education

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Summary Cystic lymphangiomas are rare malformations of the lymphatics that result in the formation of a cystic mass. Where multiple cysts are seen, the condition is termed cystic lymphangiomatosis. This case describes the diagnosis and unique management of cystic lymphangiomatosis in a 10‐day‐old Thoroughbred foal. Ultrasonography, histopathology and laparoscopy were essential for diagnosis and appreciation of the extent of disease. Ultimately, the cystic lymphangiomatosis was so extensive in this foal that complete surgical excision was considered impossible and the presence of adhesions within the abdomen indicated a very poor long‐term prognosis; the owners elected for euthanasia at age 14 weeks. Although rare, lymphangioma and lymphangiomatosis should be considered as a differential diagnosis for an intra‐abdominal mass in a young horse.

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“…A review of the veterinary literature suggests that the vast majority of vascular malformations are of blood vessel origin [5][6][7][8][9][10][11][12][13][14][15]. Only few reports confirm a lymphatic vessel origin of vascular malformations in the skin, intestines, liver and mammary gland [16][17][18][19][20][21]. Veterinary reports that manage to make a suggestion for a lymphatic origin often refer to a neoplastic origin to the lesion [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Retroperitoneal lymphatic malformation in a dog

Driessen

Cushing²

2020

Acta Vet Scand

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Background: Lymphatic vascular malformations are rare findings in canine patients with six reports available in veterinary literature. Retroperitoneal cystic lymphatic malformations have not been described previously in canine patients and neither has the use of immunohistochemistry to determine their origin, i.e. vascular versus lymphatic. Case presentation: An 8-year-old neutered female Cocker spaniel was referred for pollakiuria, dysuria and a painful abdomen. Computed tomography scanning of the abdomen showed a fluid filled structure adjacent to the urinary bladder. During surgical exploration, a thin walled cystic structure with sero-haemorrhagic fluid was found, extending from the retroperitoneal space into the abdomen. The mass was excised and submitted for histopathology, revealing a cystic mass lined by a fibrovascular capsule within the retroperitoneal/mesenteric adipose tissue. The inner surface of the cyst was lined by a single layer of bland, flattened spindle cells. Intramural blood vessels were well differentiated, with perivascular haemorrhage. On recurrence 11 months later, the mass was excised for the second time and a PleuralPort (Norfolk Animal products) was placed. Fifteen months after initial presentation, progression occurred with haemorrhagic fluid in the cystic space, pleural-and abdominal cavities and the owners opted for euthanasia. Histopathology and positive immunohistochemistry for lymphatic markers lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1) and prospero homeobox protein-1 (PROX-1) confirmed a lymphatic vascular origin of the cystic structure. Conclusions: To our experience, a definitive diagnosis of retroperitoneal cystic malformation of lymphatic origin could be done only by combining the clinical presentation, advanced imaging, histopathology and LYVE-1 and PROX-1 immunohistochemistry. This is the first report of a vascular malformation in a dog where immunohistochemistry was used to make a final diagnosis. A lymphatic malformation, even if rare, should be added on the list of the differential diagnosis in a patient with a retroperitoneal cystic structure containing serohaemorrhagic fluid. Results of this case report can aid in diagnosis of future cases, however, further studies on therapy and management are needed to provide additional information about optimal treatment of these patients.

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Congenital lymphangiomatosis and an enteric duplication cyst in a young dog

Cited by 13 publications

References 18 publications

Multimodality characterization of a noncommunicating congenital duodenal duplication cyst causing pyloric outflow obstruction in a young dog

Multimodality characterization of a noncommunicating congenital duodenal duplication cyst causing pyloric outflow obstruction in a young dog

Intra‐abdominal cystic lymphangiomatosis in a Thoroughbred foal

Retroperitoneal lymphatic malformation in a dog

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