Congenital malformation syndromes associated with peripheral neuroblastic tumors: A systematic review

Sznewajs, Aimee; Pon, Elizabeth; Matthay, Katherine K.

doi:10.1002/pbc.27901

Cited by 5 publications

(2 citation statements)

References 98 publications

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“…From 2010 to 2019, we collected clinical samples from NB (n = 9, retroperitoneal origin, mainly younger than 5 years old) ( 26 ), ganglioneuroblastoma (GNB, n = 2), olfactory neuroblastoma (ONB, n = 7), and retinoblastoma (RB, n = 6) patients in 1 st Affiliated Hospital of University of Science and Technology of Chima (USTC) and 2 nd Affiliated Hospital of Dalian Medical University (DMU) for IHC analysis ( Figures 1A–D ) to know the expression pattern of related proteins. Peripheral neuroblastic tumors are further classified based on their morphological features into NB, GNB, and ganglioneuroma (GN), known as the International Neuroblastoma Pathology Classification (INPC; Shimada system), which are relevant biologically and prognostically ( 27 ). Compared with ONB ( Figure 1C ) and RB ( Figure 1D ), the IHC staining of retroperitoneum-initiated NB showed significant higher (P < 0.05) expression of AR, SCAP, and especially the drug targets, HMGCR and CYP17A1 ( Figure 1E ).…”

Section: Resultsmentioning

confidence: 99%

Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor

Chen

Wang

et al. 2021

Front. Oncol.

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Neuroblastoma is the most common extracranial neuroendocrine tumor in childhood. Although many studies have tried to find effective treatments, there are still numerous limitations in current clinical targeted therapy. So, it is important to find new therapeutic targets and strategies from a new perspective. Our previous study reported that the androgen receptor (AR) promotes the growth of neuroblastoma in vitro and in vivo. Based on documentary investigation, we postulated that the AR–SCAP–SREBPs-CYP17/HMGCR axis may regulate cholesterol and androgens synthesis and form a positive enhancement loop promoting NB progression. Clinical samples and Oncomine database analysis proved the activation of AR–SCAP–SREBPs-CYP17/HMGCR axis in neuroblastoma. The combination of inhibitors of HMGCR (statins) and CYP17A1 (abiraterone acetate) showed synergistic effect that significantly inhibited the proliferation and migration with decreased expression of related genes detected in vitro and in vivo suggesting the dual-targeted therapy had the potential to inhibit the progression of neuroblastoma in spite of its MYCN status. This study provides new ideas for clinical treatment of neuroblastoma with efficacy and reduced toxicity.

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Section: Resultsmentioning

confidence: 99%

Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor

Chen

Wang

et al. 2021

Front. Oncol.

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“…Механизмы развития ганглионевромы до конца не выяснены. Ученые склоняются к значительной роли в данном вопросе генетического фактора [5,6].…”

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A case of ganglioneuroma in a patient with the pathology of the upper gastrointestinal tract

Варламова

Зиновьева

2021

Medicinskaâ vizualizaciâ

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In view of the rare occurrence, the small spectrum of clinical manifestations and the non-specificity of changes in instrumental and laboratory data, the diagnosis of ganglioneuroma at the moment is a very difficult task for the routine of a doctor. Ganglioneuromas have a slow growth, which leads to a long asymptomatic course and, as a result, complicates its early diagnosis. In most cases, ganglioneuroma is random. Complaints in these patients are non-specific and are directly dependent on localization.One of the available methods for imaging retroperitoneal tumors is ultrasound (ultrasound)., which makes preventive and regular ultrasound an indispensable method for early detection of extraorgan formations. This article describes the clinical case of ganglioneroma in a young man with the pathology of the upper gastrointestinal tract.

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Congenital Malignant Disorders

Lucas¹,

Huang²,

Robbins³

2024

Avery's Diseases of the Newborn

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Congenital malformation syndromes associated with peripheral neuroblastic tumors: A systematic review

Cited by 5 publications

References 98 publications

Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor

Synergistic Effect of Statins and Abiraterone Acetate on the Growth Inhibition of Neuroblastoma via Targeting Androgen Receptor

A case of ganglioneuroma in a patient with the pathology of the upper gastrointestinal tract

Congenital Malignant Disorders

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