Congenital malformations in 4224 children conceived after IVF

Anthony, S.; Buitendijk, S.E.; Dorrepaal, Caroline; Lindner, Kurt; Braat, D.D.M.; Ouden, A.L. den

doi:10.1093/humrep/17.8.2089

Cited by 144 publications

(91 citation statements)

References 30 publications

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“…The details of the meta-analysis-including the literature search, the study selection and the data extraction processes-are described there. We found 19 studies [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] for inclusion in the meta-analysis and found that ART increased the risk of MM with an odds ratio of 1.29 (95% CI 1.01-1.67). Our major conclusion was that the risk we found may be inflated by the fact that none of the studies used the most appropriate control group, namely subfertile couples conceiving spontaneously.…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

Rimm

Katayama

Katayama³

2011

J Assist Reprod Genet

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Objective To estimate the effect of assisted reproductive technology (ART) on major malformation (MM) rate in ART offspring independent of the effect of subfertility on MM. Design Meta-analysis. Methods This meta-analysis is based on our previously published meta-analysis of observational studies evaluating the relationship between ART treatment and MM rates, as well as recent research by Zhu et al. to estimate the impact of subfertility alone on MM in subfertile couples conceiving spontaneously. Results The overall odds ratio for MM in our original metaanalysis, in which all studies used apparently inappropriate control groups of "normal" populations, was 1.29 (95% CI 1.01-1.67). Here we attempted to estimate the risk of subfertility and used this estimate to perform an adjusted meta-analysis. Zhu et al. found that about 40% of the odds of MM was due to subfertility. When we took Zhu's finding into account, the adjusted odds ratio in the meta-analysis was 1.01 (95% CI 0.82-1.23). Conclusions Our study suggests ART does not increase the risk of MM as much as previously reported. More research is needed to quantify the underlying risk of subfertility and separate it from the risk associated with ART. Physicians who counsel subfertile couples should recognize that previous studies of MM rates in ART patients probably overestimated the risk.

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Section: Introductionmentioning

confidence: 99%

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

Rimm

Katayama

Katayama³

2011

J Assist Reprod Genet

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“…With increasing numbers of infants born following IVF, a number of issues related to these infants have come to the fore in medical literature. These issues include increased infant mortality rates, failure to thrive, increased morbidity in early childhood [1], increased risk of congenital anomalies [2][3][4] and increased incidence of adverse neurological sequelae [5].…”

Section: Introductionmentioning

confidence: 99%

Profile of Live-born Infants of In-vitro Fertilisation

Narayan¹,

Rana

Sharma

et al. 2010

Medical Journal Armed Forces India

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“…In a Dutch registry study, major birth defects in 4224 ART children were compared to 314,605 naturally conceived children [34]. Major birth defect rates were 3.2 % and 2.7 % for ART and naturally conceived children respectively, but the significance of the difference disappeared after adjustment for maternal age, parity and ethnicity.…”

Section: Congenital Malformationsmentioning

confidence: 99%

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

Albertini

Evers²,

Geraedts³

et al. 2014

J Assist Reprod Genet

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Purpose Assisted Reproduction Treatment (ART) is here to stay. This review addresses the parental background of birth defects, before, during and after conception and focuses both on the underlying subfertility and on the question whether ART as a treatment is an additional contributing factor. Methods Searches were performed in Medline and other databases. Summaries were discussed in a Delphi panel set-up by the European Society of Human Reproduction and Embryology (ESHRE). Results Several birth defects and adult diseases arise during the earliest stages of ovarian development and oocyte differentiation: this is the case of cleft palate disorders in offspring from female rat exposed to Dioxin during fetal life or the polycystic ovary diseases in female offspring (primates) exposed to elevated androgen concentration during fetal life. Human oocytes and embryos often fail to stop the propagation of aneuploid cells but maintain their ability to repair DNA damages including those introduced by the fertilizing sperm. There is a 29 % increased risk of birth defects in the newborns spontaneously conceived by subfertile couples and the risk is further increased (34 %) when conception is achieved by treating infertlity with ART (Danish IVF Registry). Periconceptional conditions are critical for ART babies: their birth weight is in general smaller (Norvegian Registry) but a more prolonged culture time doubled the number of large babies (Finnish Registry). Conclusion The long-term developmental effects of ART on child and subsequent health as an adult remains a subject worthy of futher monitoring and investigation. Capsule Remaining mindful of the growing body of evidence showing that during gamete production, genetic and epigenetic changes influence offspring health, serves to reinforce the need to continue to monitor ART children.

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Congenital malformations in 4224 children conceived after IVF

Abstract: The small increase in overall congenital malformations observed in the IVF children appears to be attributable to differences in maternal characteristics and not to any aspect of the IVF procedure.

Cited by 144 publications

References 30 publications

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

A meta-analysis of the impact of IVF and ICSI on major malformations after adjusting for the effect of subfertility

Profile of Live-born Infants of In-vitro Fertilisation

Birth defects and congenital health risks in children conceived through assisted reproduction technology (ART): a meeting report

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