Congenital melanocytic nevi: Clinical and histopathologic features, risk of melanoma, and clinical management

Tannous, Zeina; Mihm, Martín C.; Sober, Arthur J.; Duncan, Lyn M.

doi:10.1016/j.jaad.2004.07.020

Cited by 298 publications

(231 citation statements)

References 52 publications

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“…However, the limited number of reports on follow-up data on patients with proliferative nodules in nevi and scattered reports indicating that patients with a proliferative nodule may have an increased risk of developing melanoma confound the issue [17]. Briefly, the lifetime risk of melanoma for patients with giant congenital nevi believed to vary anywhere from 4-50% while the cumulative risk of melanoma incidence in small congenital nevi is lower and ranges form 2.6 -4.9%.…”

Section: Discussionmentioning

confidence: 99%

Proliferative Nodules in Congenital Nevi - A Histopathologic, Genetic and Immunohistochemical Reappraisal

Brahmbhatt¹,

Yang²,

Mahalingam³

2010

J Clin Exp Dermatol

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Section: Discussionmentioning

confidence: 99%

Proliferative Nodules in Congenital Nevi - A Histopathologic, Genetic and Immunohistochemical Reappraisal

Brahmbhatt¹,

Yang²,

Mahalingam³

2010

J Clin Exp Dermatol

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“…One condition that has a known predisposition to transformation into melanoma is that of giant congenital melanocytic nevus (GCMN). GCMN is defined as a melanocytic nevus that is greater than 20 cm in diameter or, alternatively, that occupies more than 2% of the body's surface area [Chung et al, 2006;Tannous et al, 2005a]. The incidence of GCMN has an incidence of approximately 1 in 20,000 newborns.…”

Section: Risk Factors/diagnosismentioning

confidence: 99%

“…Patients who have undergone excision of a GCMN may still develop an extracutaneous melanoma on rare occasions and therefore should undergo long-term surveillance [Krengel et al, 2008]. In addition, congenital melanocytic nevi that are not considered "giant" still carry up to a 1-5% risk of malignant transformation, so these should also be carefully observed or, in some cases, prophylactically excised [Tannous et al, 2005b]. A rare condition that predisposes children to melanoma is xeroderma pigmentosum, which renders affected individuals 2,000 more times likely to develop melanoma than children without the condition [Pappo, 2003].…”

Section: Risk Factors/diagnosismentioning

confidence: 99%

Challenging Problems in the Surgical Management of Melanoma

Ganapathi¹,

Tyler²,

Mosca³

2011

Current Management of Malignant Melanoma

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“…Dermal nodules are considered benign in GCN that are present at birth, or which develop during childhood [3]. Skeletal developmental abnormalities have been reported to be associated with congenital nevi, especially GCN [4]. The risk of malignant change is probably the most contentious issue in their management.…”

mentioning

confidence: 99%

A change in birth mark

2013

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A 29-year-old man presented with change in his truncal ''birthmark''. He had a giant coat-like, well-defined, cobble stone, hairy congenital melanocytic nevus occupying the whole chest, upper abdomen, left arm, and neck with multiple satellite nevi scattered on other parts of body (Fig. 1a, b). The lesion and several nodules all over the nevus were present with no significant alteration from childhood until the week before, when he had noticed a change in consistency and color of a tiny focus of the main part of the nevus on his left hemithorax. The general physical examination was normal including skeletal examination. Biopsy of the focus was done that showed benign congenital nevomelanocytic proliferation with deep malignant melanoma transformation. On further investigation, there was a nodule in the lung. A biopsy from the lung lesion was performed that revealed metastatic melanoma. The patient was referred to the medical oncology unit for treatment.Giant congenital nevi (GCN) are often defined as nevi that are greater than 20 cm in the greatest dimension [1], or nevi that occupy 30 % or more of the body surface area [2]. These GCN may be encountered in 1 out of 500,000 live births [3]. Dermal nodules are considered benign in GCN that are present at birth, or which develop during childhood [3]. Skeletal developmental abnormalities have been reported to be associated with congenital nevi, especially GCN [4]. The risk of malignant change is probably the most contentious issue in their management. There is a consensus that GCN are pre-malignant, but the lifetime risk of this ominous transformation is purported to be 3.1 % [5]. It is generally accepted that a complete excision in early childhood decreases the risk of malignancy. Another option (in cases with extensive dermal involvement) is a close monitoring by physical examination, including lymph node palpation and dermoscopy, with periodic follow-up and prompt excision if the lesion presents variations [6].Conflict of interest The authors declare no conflict of interest.

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Congenital melanocytic nevi: Clinical and histopathologic features, risk of melanoma, and clinical management

Cited by 298 publications

References 52 publications

Proliferative Nodules in Congenital Nevi - A Histopathologic, Genetic and Immunohistochemical Reappraisal

Proliferative Nodules in Congenital Nevi - A Histopathologic, Genetic and Immunohistochemical Reappraisal

Challenging Problems in the Surgical Management of Melanoma

A change in birth mark

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