Congenital Melanocytic Nevi With Placental Infiltration by Melanocytes

Ball, Russell A.; Genest, David R.; Sander, Maureen; Schmidt, Birgitta; Barnhill, Raymond L.

doi:10.1001/archderm.134.6.711

Cited by 18 publications

(6 citation statements)

References 15 publications

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“…Because of the theoretical risk of transmission from mother to fetus, placentas should be examined for gross and histopathological evidence of metastatic disease with maternal history of invasive melanoma. When present, placental metastases rarely lead to congenital melanoma; some placental deposits also appear benign and may represent developmental arrests or “benign seeding” of the placenta . Nonetheless, the finding of placental involvement by melanocytic deposits warrants careful examination and follow‐up of the newborn.…”

Section: Subtypes Of Pediatric Melanomamentioning

confidence: 99%

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Pathology and genomics of pediatric melanoma: A critical reexamination and new insights

Bahrami

Barnhill

2017

Pediatric Blood & Cancer

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The clinicopathologic features of pediatric melanoma are distinct from those of the adult counterpart. For example, most childhood melanomas exhibit a uniquely favorable biologic behavior, save for those arising in large/giant congenital nevi. Recent studies suggest that the characteristically favorable biologic behavior of childhood melanoma may be related to extreme telomere shortening and dysfunction in the cancer cells. Herein, we review the genomic profiles that have been defined for the different subtypes of pediatric melanoma and particularly emphasize the potential prognostic value of telomerase reverse transcriptase alterations for these tumors.

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Section: Subtypes Of Pediatric Melanomamentioning

confidence: 99%

“…When present, placental metastases rarely lead to congenital melanoma; some placental deposits also appear benign and may represent developmental arrests or "benign seeding" of the placenta. 100 Nonetheless, the finding of placental involvement by melanocytic deposits warrants careful examination and follow-up of the newborn.…”

Section: Congenital Melanomamentioning

confidence: 99%

Pathology and genomics of pediatric melanoma: A critical reexamination and new insights

Bahrami

Barnhill

2017

Pediatric Blood & Cancer

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“…Accordingly, definitive diagnosis requires proof of the presence of exogenous cells in the infant, and classic histopathology may be inconclusive. Of note, placental infiltration by benign‐appearing melanocytes has been reported in association with CMN with no evidence maternal or primary congenital melanoma . Accordingly, the demonstration of melanocytes in the placenta cannot serve as bona fide evidence of transplacental metastasis in this setting.…”

Section: Discussionmentioning

confidence: 99%

Congenital nevi versus metastatic melanoma in a newborn to a mother with malignant melanoma – diagnosis supported by sex chromosome analysis and Imaging Mass Spectrometry

et al. 2015

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A 37-year-old pregnant woman presented with a 2-cm irregular reddish nodule on her left upper arm during pregnancy. A biopsy from the lesion showed a 2.2-mm thick malignant melanoma with intravascular invasion, 25 mitosis/mm(2) and no ulceration. Following induction of labor, the patient underwent re-excision with sentinel lymph node biopsy. This showed no residual melanoma and no lymph node metastasis. The newborn boy had multiple pigmented lesions on the trunk, some of which were large and irregular. Two were biopsied and histologic examination showed dense dermal proliferation of medium sized melanocytes with multiple mitotic figures and no maturation with their descent into the dermis, raising suspicion of transplacental metastases. Examination of the placenta failed to show metastatic lesions. Multiplex polymerase chain reaction (PCR)-based genotyping, including testing for amelogenin locus for sex chromosome determination, demonstrated the presence of Y chromosome material in the melanocytes of the newborn's lesions excluding maternal origin. A diagnosis of congenital nevi was rendered. Subsequently, Imaging Mass Spectrometric analysis of the mother's lesion showed proteomic signature expression indicative of malignant melanoma, whereas the two lesions in the newborn showed changes indicative of nevi. This case demonstrates the utility of genotyping and Mass Spectrometry analysis in this challenging clinical scenario.

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“…Because of the theoretical risk of transmission from the mother to the fetus, the placentas should be examined for gross and histopathological evidence of metastatic melanoma in cases of maternal melanoma more than 1 mm in thickness. Even when present, these placental metastases only rarely lead to congenital melanoma; some of the latter placental deposits also appear to be benign and may represent developmental arrests or "benign seeding" of the placenta [ 75 ]. Nonetheless the fi nding of placental involvement by melanocytic deposits warrants careful examination and follow-up of the newborn.…”

Section: Congenital/neonatal Melanomamentioning

confidence: 99%