Congenital mesoblastic nephroma: possible prognostic and management value of assessing DNA content.

Barrantes, José; Toyn, C. E.; Muir, K. R.; Parkes, S. E.; Raafat, F.; Cameron, A. H.; Marsden, H. B.; Mann, J. R.

doi:10.1136/jcp.44.4.317

Cited by 13 publications

(12 citation statements)

References 21 publications

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“…It is interesting to note that tumors with atypical cellular histology have been reported to behave more aggresively, while 1 of 4 atypical CMNs showed a good prognosis in spite of DNA aneuploidy. This is consistent with the report of Barrantes et al [30] Unfortunately, the number of patients was too small to allow a concrete conclusion, so studies on larger numbers of patients with CMN are required to clarify this point.…”

Section: Discussionsupporting

confidence: 81%

Flow Cytometric Nuclear DNA Content Analysis of Renal Tumors in Children: Prognostic Significance of Nuclear DNA Ploidy

Yokomori²,

Tsuchida³

et al. 1995

Tumor Biol

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We studied, by flow cytometry, the DNA contents of paraffin-embedded tumor specimens from 90 infants and children with kidney tumors, and analyzed the relationship of DNA ploidy with histological types and prognosis. Data of adequate quality were obtained from 90 cases: 65 tumors with favorable histology, 5 congenital mesoblastic nephromas and 20 tumors with unfavorable histology. The 90 cases had nuclear DNA histogram patterns that were classified as DNA diploid in 64 tumors, aneuploid in 19 and tetraploid in 7. There were no significant correlations between DNA ploidy and histological types or clinical stages. Survival rates for patients with diploidy were 80 and 70% at 2 and 5 years, respectively, and those of patients with aneuploidy were 72 and 61 % at 2 and 5 years, respectively. On the other hand, patients with a DNA tetraploid pattern had significantly worse survival rates of 43 and 29% at 2 and 5 years, respectively. Among patients with aneuploidy or tetraploidy, the S-phase fractions in those who died (mean ± SD: 10.3 ± 4.1 and 22.1 ± 11.6%, respectively) appear to be greater than those in their surviving counterparts (8.8 ± 4.0 and 12.1 ± 2.8%). Hence, although the differences between diploid and aneuploid DNA patterns were not correlated with differential prognosis in children with kidney tumors, a tetraploid pattern clearly indicates a poor prognosis, especially in combination with histological types and clinical stages.

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Section: Discussionsupporting

confidence: 81%

Flow Cytometric Nuclear DNA Content Analysis of Renal Tumors in Children: Prognostic Significance of Nuclear DNA Ploidy

Yokomori²,

Tsuchida³

et al. 1995

Tumor Biol

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“…Congenital anomalies were reported in 11 patients described in series; genitourinary anomalies were described in six patients, gastrointestinal malformations in two patients, polydactyly in one patient, hydrocephalus in one patient, and one patient was described to be diagnosed with Beckwith–Wiedemann syndrome (BWS) . In case reports, two additional patients with BWS were diagnosed with CMN …”

Section: Resultsmentioning

confidence: 99%

“…Reasons for stage III disease were positive surgical margins (n = 13), tumor rupture (n = 12), or a combination of positive surgical margins and tumor rupture (n = 11), while the reason for stage III was unknown in eight patients . One patient was described to have stage IV disease because of “suspected” malignant cells in the bone marrow; however, these cells were not histologically proven to be CMN cells, so we consider this case not being stage IV . In case reports, another case was described to have stage IV disease at diagnosis (lesions in the right tibia on computed tomography scan but no histologic confirmation available) .…”

Section: Resultsmentioning

confidence: 99%

“…Postoperative chemotherapy had been administered in 50 patients, consisting of AV in 21 cases, actinomycin alone in 11 cases, AV and doxorubicin in 3 cases, AV and cyclophosphamide in 1 case, etoposide/cyclophosphamide/doxorubicin/carboplatin in 1 case, and type of postoperative chemotherapy was unknown in 13 cases . Radiotherapy was applied in nine cases …”

Section: Resultsmentioning

confidence: 99%

“…CMN most commonly occurs early in infancy and over 15% of the cases are detected prenatally . Although CMN has been reported in 26 adult patients in literature, it remains uncertain whether these cases are real CMN's .…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Congenital mesoblastic nephroma 50 years after its recognition: A narrative review

Gooskens

Houwing

Vujanić

et al. 2017

Pediatr Blood Cancer

106

120

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Congenital mesoblastic nephroma (CMN) is a rare pediatric renal tumor with low malignant potential that most commonly occurs early in infancy. Treatment strategies are based on the few published CMN series, while a significant number of CMN patients have been described in case reports. The aim of this narrative review was to create an up-to-date overview of the literature. Complete surgical removal is curative in most cases. The risk of treatment-related mortality (both surgery- and chemotherapy-related) is relatively high in the first weeks of life, indicating that these young patients deserve special attention with respect to timing and type of treatment.

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Thirty‐year population‐based review of childhood renal tumours with an assessment of prognostic features including tumour DNA characteristics

Barrantes

Muir

Toyn

et al. 1993

Med. Pediatr. Oncol.

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We have reviewed all paediatric kidney tumours seen in the West Midlands Health Authority Region over a 30-year period. There were 205 cases confirmed after a review of the pathology by three paediatric pathologists. Seven were cases of bone metastasising renal tumour (clear cell sarcoma), 5 were rhabdoid tumours, 2 were renal cell carcinomas, and 13 were mesoblastic nephromas. In 3 cases, it was not possible to define further the histological diagnosis. The remaining 175 cases were considered to be Wilms' tumour (86%), which is equivalent to an incidence of 5.7/10(6)/year. In the cases of Wilms' tumour, there were 91 boys and 84 girls (1.1:1). The majority of patients were Caucasian with only 7% of non-Caucasian origin. At presentation, 78% of the patients were less than 5 years old. All of these patients except 9 had surgery as part of their treatment, 154 children had total nephrectomy, 3 had partial nephrectomy, and 9 had other surgical procedures. The majority also received chemotherapy and radiotherapy. Sex, chemotherapy, and stage all had prognostic significance in univariate analysis. The actuarial survival at 10 years increased from 17% for patients treated in the first decade of the study to 78% for patients treated in the third. DNA characteristics were investigated using flow cytometry in paraffin-embedded material and adequate information was obtained in 73 cases of Wilms' tumour. Only 7 had aneuploid tumours. Univariate survival analysis of these 73 results showed that stage, sex, the percentage of cells in the synthetic phase and the proliferative index from the DNA investigations had predictive value.

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Congenital mesoblastic nephroma: possible prognostic and management value of assessing DNA content.

Cited by 13 publications

References 21 publications

Flow Cytometric Nuclear DNA Content Analysis of Renal Tumors in Children: Prognostic Significance of Nuclear DNA Ploidy

Flow Cytometric Nuclear DNA Content Analysis of Renal Tumors in Children: Prognostic Significance of Nuclear DNA Ploidy

Congenital mesoblastic nephroma 50 years after its recognition: A narrative review

Thirty‐year population‐based review of childhood renal tumours with an assessment of prognostic features including tumour DNA characteristics

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