Congenital papillomas and papillomatoses associated with the Human Papilloma Virus (HPV): report on 5 cases

Abstract

The authors present a study of five cases of vulvar congenital papillomas and papillomatoses in stillborns and neonates dead upon birth. The studied material was collected from five necropsies. The histopathological evaluation showed hyperkeratosis, acanthosis, papillomatosis, perinuclear haloes, and nuclear abnormalities. In three of the cases, the electron microscopy identified nuclear and cytoplasmatic viral particles ranging from 40 to 60 nm in size, compatible with HPV. The immunohistochemical study of those lesions showed nuclear and cytoplasmatic positivity. The authors concluded that the presence of viral particles suggestive of HPV added to the immunopositivity indicated the possibility of viral infection.

Congenitale cutane fibropapillomatose bij een warmbloedveulen

“…A viral component in this disease would open perspectives for medical treatment and/or vaccination in case excision would be difficult or even impossible, for example in the ocular region. In contrast with equine cutaneous papillomas acquired later in life, and in contrast with congenital anogenital papillomas associated with papillomavirus infection in humans (Dias et al, 1995), this case study is in agreement with other reports that histopathological evidence of viral infection in equine congenital papillomas is lacking. Therefore, clinical or experimental proof for this viral pathogenesis remains elusive.…”

Infecção oral pelo HPV e lesões epiteliais proliferativas associadas

“…O tropismo dos mais de 150 tipos do papilomavírus humano (HPV) pelos vários revestimentos escamosos do corpo humano e a variedade de lesões epiteliais proliferativas benignas e malignas possivelmente se devem mais a suas diferenças do que semelhanças (2,11,13,15,51) . A infecção da mucosa oral, bem como a patogenia das lesões orais associadas ao HPV, ainda não é completamente conhecida, podendo a infecção ocorrer durante a gravidez, no parto vaginal, por autoinoculação ou sexo oral (3,4,6,10,41,43) . Parece que a saliva tem papel protetor devido à presença de agentes antimicrobianos como lisozimas, lactoferrina, imunoglobulina A (IgA) e citocinas (3) .…”