Congenital Prepubic Sinus

Daher, P.; Diab, Nawras; Moussa, Ch.; Korkmaz, Gülten

doi:10.1055/s-2008-1066083

Cited by 18 publications

(14 citation statements)

References 1 publication

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“…Various cases have been reported since Campbell et al [1] first described 3 cases of congenital prepubic fistula in 1987. The anatomy of this pathologic lesion has been well documented [2][3][4][5][6]. However, complete removal the fistular tract still remains challenging because of its complicated course.…”

mentioning

confidence: 98%

Usefulness of magnetic resonance imaging for congenital prepubic fistula

Sasaki¹,

Deguchi²,

Tsukada³

et al. 2010

Journal of Pediatric Surgery

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mentioning

confidence: 98%

Usefulness of magnetic resonance imaging for congenital prepubic fistula

Sasaki¹,

Deguchi²,

Tsukada³

et al. 2010

Journal of Pediatric Surgery

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“…[1][2][3][4][5][6] CPS represents a tract which commences in the skin overlying the pubic symphysis The other theory is that CPS is a variant of dorsal urethral duplication. [2][3][4] The epithelium of the entire female urethra and most of the male develops from the endoderm of the urogenital sinus. However, the distal portion of the male urethra is derived from the ectodermic glandular plate, which grows backwards from the tip of glans penis to meet the urogenital sinus.…”

Section: Case Reportmentioning

confidence: 99%

“…Proximal transitional and distal squamous epithelium of the tracts surrounded by smooth muscle bundles with no inflammatory exudates suggests that these lesions may be a variant of dorsal urethral duplication. 2,3 Various urethral duplications may occur at any point during development.…”

Section: Case Reportmentioning

confidence: 99%

“…However, the distal portion of the male urethra is derived from the ectodermic glandular plate, which grows backwards from the tip of glans penis to meet the urogenital sinus. 2 The epithelium of the male urethra consists of 3 types. In the prostatic urethra the lining epithelium is transitional, which is followed by a shift to a stratified or pseudostratified columnar epithelium towards the middle urethra.…”

Section: Case Reportmentioning

confidence: 99%

“…There are 2 theories that have been proposed, including an anomalous anterior abdominal wall closure or variant of dorsal urethral duplication. [1][2][3][4] To explore the etiology, we performed immunohistochemical study with 3 cytokeratin antibodies that are known to be specific for differentiation between transitional and squamous epithelium. …”

mentioning

confidence: 99%

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Congenital Prepubic Sinus: A Variant of Urethral Duplication

et al. 2007

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Congenital prepubic sinus (CPS) is an extremely rare congenital anomaly of the external genitalia of uncertain etiology. Herein, a case of CPS, where immunohistochemical staining was performed to elucidate the etiology of the sinus, is reported. The results of the immunohistochemical study demonstrated the lining epithelium was transitional proximally and squamous distally. Congenital prepubic sinus (CPS) is a rare congenital anomaly which is associated with discharge from an opening overlying the pubis symphysis. Various names including congenital prepubic sinus, subpubic fistula, prepubic dermoid sinus, and suprapubic dermoid sinus, were used to identify these lesions.The etiology of CPS is still controversial. There are 2 theories that have been proposed, including an anomalous anterior abdominal wall closure or variant of dorsal urethral duplication. [1][2][3][4] To explore the etiology, we performed immunohistochemical study with 3 cytokeratin antibodies that are known to be specific for differentiation between transitional and squamous epithelium. CASE REPORTA 3-year-old boy presented with a discharging sinus in the prepubic region since birth. A tiny opening was located in the midline prepubic area on the dorsal radix of the penis (Fig. 1A).He had no other signs and symptoms related to the genitourinary tract. Clinical and laboratory findings were normal.Ultrasonography found a linear tubular structure in the midline prepubic region. Fistulography showed a noncommunicating fistulous tract toward the bladder neck. Surgical exploration was carried out and found a 4 cm long tract that ended blindly as a fibrous band at the anterior surface of the pubic symphysis, which was then excised (Fig. 1B). The specimen was divided into 2 segments from the middle area, and the cross sections were embedded into 2 paraffin blocks labeled as proximal and distal parts, respectively. Routine hematoxylin and eosin stain was performed on the histological sections. Successive sections were prepared for immunohistochemical analysis with monoclonal antibodies (DAKO A/S Glostrup, Denmark), including low and high molecular weight cytokeratin (CK 7, 8 and 903).Hematoxylin and eosin stain demonstrated transitional and squamous epithelium lining the sinus ( Fig. 2A, B). Immunohistochemical study showed that the stains with 3 cytokeratin antibodies were moderately to strongly positive at the proximal part ( Fig. 2C). At the distal part, high molecular weight cytokeratin stain with CK903 antibody was still strongly positive ( Fig. 2D), while low molecular weight cytokeratin stain was weakly to moderately positive. These results suggested that the lining epithelium was transitional proximally and squamous distally.

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Congenital prepubic sinus: Is it a residual cloacal membrane and umbilicophallic groove?

Tsukamoto

Yamataka

Kuga

et al. 2004

Pediatric Surgery International

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We report two cases of congenital prepubic sinus (CPS) and discuss theories about its embryology and the etiology of its variants to improve the global understanding of this uncommon anomaly. Based on a review of the scant number of reported cases and our own experience, we postulate that CPS may be caused by a residual cloacal membrane and umbilicophallic groove and that its depth may determine the position of its ending.

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Congenital Prepubic Sinus

Cited by 18 publications

References 1 publication

Usefulness of magnetic resonance imaging for congenital prepubic fistula

Usefulness of magnetic resonance imaging for congenital prepubic fistula

Congenital Prepubic Sinus: A Variant of Urethral Duplication

Congenital prepubic sinus: Is it a residual cloacal membrane and umbilicophallic groove?

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