Congenital renal tract anomalies: outcome and follow‐up of 402 cases detected antenatally between 1986 and 2001

Damen-Elias, H. A. M.; Jong, Tom P.V.M. de; Stigter, R. H.; Visser, Gerhard H.; Stoutenbeek, P.

doi:10.1002/uog.1788

Cited by 59 publications

(57 citation statements)

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“…At baseline, the clinical data for our series were similar to the data reported in observational studies by showing a higher proportion of males and mild to moderate ANH (24)(25)(26). There has been an agreement among several studies that the degree of ANH is associated with postnatal outcome (8,13).…”

Section: Discussionsupporting

confidence: 87%

Clinical Course of 822 Children with Prenatally Detected Nephrouropathies

Quirino

Diniz

Bouzada

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives With the advent of fetal screening ultrasonography, the detection of congenital anomalies of the kidney and urinary tract (CAKUT) in utero has permitted early management of these conditions. This study aims to describe the clinical course of a large cohort of patients with prenatally detected nephrouropathies.Design, setting, participants, & measurements In this retrospective cohort study, 822 patients were prenatally diagnosed with CAKUT and systematically followed up at a tertiary Renal Unit for a median time of 43 months. Variables included in the analysis were sex, laterality, fetal ultrasonography (isolated versus associated hydronephrosis), and presence/absence of nephrouropathies. The events of interest were urinary tract infection, surgical interventions, hypertension, CKD, and death. Survival analyses were performed to evaluate time until occurrence of the events of interest.Results Urinary tract infection occurred in 245 (29.8%) children, with higher risk in females (hazard ratio=1.30, 95% confidence interval=1.02-1.70, P=0.05); 22 patients (2.7%) had hypertension, and 49 (6%) patients developed CKD. The risk of CKD was greater in patients with associated hydronephrosis (hazard ratio=5.20, 95% confidence interval=2.90-9.30, P,0.001). Twelve patients (1.5%) died during follow-up. Death was significantly associated with being born during the first period of the study (hazard ratio=6.00, 95% confidence interval=1.60-22.50, P,0.001), associated hydronephrosis (hazard ratio=9.30, 95% confidence interval=2.90-29.30, P,0.001), and CKD (hazard ratio=170.00, 95% confidence interval=41.00-228.00, P,0.001).Conclusions In our series, the clinical course of prenatally detected CAKUT was heterogeneous, and those infants with associated hydronephrosis at baseline were identified as a high-risk subgroup.

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Section: Discussionsupporting

confidence: 87%

Clinical Course of 822 Children with Prenatally Detected Nephrouropathies

Quirino

Diniz

Bouzada

et al. 2012

Clinical Journal of the American Society of Nephrology

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“…In our study, there was a predominance of urinary tract dilatation (62%), and the mortality rate in this group varied according to kidney involvement (12-64%). In another follow-up study at a tertiary center, Damen-Elias et al [43] found a similar proportion of urinary tract dilatation (61%) and a comparable mortality rate (13.4%) for this group. In addition, they also reported a significant increase in mortality rate among patients with structural kidney anomalies (50.6%).…”

Section: Discussionmentioning

confidence: 53%

Early risk factors for neonatal mortality in CAKUT: analysis of 524 affected newborns

et al. 2012

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“…Damen-Elias HA et al (2001), chromosomal studies on amniotic fluid should be offered in cases with renal malformation; the incidence of chromosomal abnormality in has reported to be 8-12% 16 .…”

Section: Discussionmentioning

confidence: 99%

Study of Ultrasonographic Evaluation of Congenital Renal Anomalies and Their Prognostic Significance

Sengar¹,

Badola²,

Nath³

et al. 2016

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BACKGROUNDRenal abnormalities are the most common disorder seen on ultrasound. Congenital abnormalities of the kidney and urinary tract occur in approximately 3.3-11.1% of the population and they account for about 50% of all congenital abnormalities. This study was done to assess the role of ultrasonography in early detection of malformation in foetal urinary tract and their proper management. If these anomalies are not diagnosed by prenatal ultrasound, many of these would manifest later in life as pyelonephritis, obstruction, stone formation, hypertension, or end-stage renal disease (ESRD).

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Congenital renal tract anomalies: outcome and follow‐up of 402 cases detected antenatally between 1986 and 2001

Abstract: Objective To determine the long-term prognosis of antenatally detected renal tract anomalies in order to

Cited by 59 publications

References 44 publications

Clinical Course of 822 Children with Prenatally Detected Nephrouropathies

Clinical Course of 822 Children with Prenatally Detected Nephrouropathies

Early risk factors for neonatal mortality in CAKUT: analysis of 524 affected newborns

Study of Ultrasonographic Evaluation of Congenital Renal Anomalies and Their Prognostic Significance

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