Congenital rubella syndrome—major review

Duszak, Robert S.

doi:10.1016/j.optm.2008.03.006

Cited by 161 publications

(81 citation statements)

References 41 publications

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“…The consequences of congenital rubella infection during the first 18 weeks of gestation include abortion, miscarriage, stillbirth, and a pattern of birth defects called CRS (5). The risk of CRS is related to gestational age at the time of maternal infection.…”

Section: Discussionmentioning

confidence: 99%

Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013–2014

et al. 2016

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SUMMARY: Rubella is usually a mild illness, with febrile rash being its main symptom. However, serious consequences of rubella infection can result when the infection occurs during the early stages of pregnancy. After the occurrence of a rubella outbreak in Japan that was observed from 2012 to 2013, 45 infants were reportedly born with congenital rubella syndrome (CRS). We prospectively followed the 15 CRS cases reported in Tokyo to determine the virus shedding periods by using nested reverse transcriptase-polymerase chain reaction to detect rubella virus genes. Throast swabs were used for virus detection. The virus shedding period was measured from birth until the time when the sample last tested positive followed by 2 consecutive negative samples. Kaplan-Meier method was used to estimate the proportion of cases remaining positive for rubella virus genes over time. The proportion of CRS cases shedding virus dropped steadily after birth, dropping to 33.8z at 6 months and 16.9z at 12 months. Our findings also suggested that the earlier the mother's onset of rubella during pregnancy, the longer the infant remained positive. Based on our findings, we believe that infants with CRS should be monitored for rubella virus shedding until 1 year of age.

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Section: Discussionmentioning

confidence: 99%

Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013–2014

et al. 2016

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“…Rubella virus, which belongs to the Togaviridae family, is associated with congenital rubella syndrome (CRS), a major cause of developmental abnormalities, including blindness and deafness (Banatvala and Brown 2004;Duszak 2009). …”

Section: Microbes and The Placental Barriermentioning

confidence: 99%

Concepts and Mechanisms: Crossing Host Barriers

Doran

Banerjee

Disson

et al. 2013

Cold Spring Harbor Perspectives in Medicine

113

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“…A couple of rare environmental exposures during pregnancy also increase the risk of ASD (Chess, 1971). Rubella exposure during the first trimester clearly increases the risk of ASD; although congenital rubella syndrome also includes sensorineural deafness, eye abnormalities, intellectual disability, and cardiac malformations (Duszak, 2009). First-trimester exposure to thalidomide also increases risk; although this is also associated with limb, eye, and cardiac malformations (Stromland et al, 1994).…”

Section: Parental and Prenatal Factorsmentioning

confidence: 99%

Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

Veenstra‐VanderWeele

Blakely

2011

Neuropsychopharmacol

112

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Autism Spectrum Disorder (ASD) is a common neurodevelopmental disorder affecting approximately 1% of children. ASD is defined by core symptoms in two domains: negative symptoms of impairment in social and communication function, and positive symptoms of restricted and repetitive behaviors. Available treatments are inadequate for treating both core symptoms and associated conditions. Twin studies indicate that ASD susceptibility has a large heritable component. Genetic studies have identified promising leads, with converging insights emerging from single-gene disorders that bear ASD features, with particular interest in mammalian target of rapamycin (mTOR)-linked synaptic plasticity mechanisms. Mouse models of these disorders are revealing not only opportunities to model behavioral perturbations across species, but also evidence of postnatal rescue of brain and behavioral phenotypes. An intense search for ASD biomarkers has consistently pointed to elevated platelet serotonin (5-HT) levels and a surge in brain growth in the first 2 years of life. Following a review of the diversity of ASD phenotypes and its genetic origins and biomarkers, we discuss opportunities for translation of these findings into novel ASD treatments, focusing on mTor-and 5-HT-signaling pathways, and their possible intersection. Paralleling the progress made in understanding the root causes of rare genetic syndromes that affect cognitive development, we anticipate progress in models systems using bona fide ASD-associated molecular changes that have the potential to accelerate the development of ASD diagnostics and therapeutics.

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Congenital rubella syndrome—major review

Cited by 161 publications

References 41 publications

Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013–2014

Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013–2014

Concepts and Mechanisms: Crossing Host Barriers

Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

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Congenital rubella syndrome—major review

Cited by 161 publications

References 41 publications

Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013&ndash;2014

Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013&ndash;2014

Concepts and Mechanisms: Crossing Host Barriers

Networking in Autism: Leveraging Genetic, Biomarker and Model System Findings in the Search for New Treatments

Contact Info

Product

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Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013–2014

Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013–2014