Congenital rubella syndrome: New clinical aspects with recovery of virus from affected infants

Pathology of congenital rubella in Jamaica.

“…Our findings on the whole are similar to those previously reported, with the exception of the absence of severe myocardial damage as described by Korones et al (1965), and hepatic damage. In addition, we have found a significant number of cases showing calcification in the kidneys and brain and in one case in the thymus, and nephrosclerosis.…”

“…Several cases showed mild degrees of fatty change, a not uncommon finding in our necropsies, and most showed passive congestion, presumably related to congestive failure. Pneumonitis was seen in all the liveborn infants in Histologically, the myocardial degeneration des-varying degrees of severity, ranging from a few cribed by Korones et al (1965) was not seen in any patchy areas in Case 7 to the most extensive case, in spite of the electrocardiographic changes involvement in Case 4, the oldest. There was no suggestive of myocardial damage.…”

“…However, apart from isolated case reports (Lambert, Stern, and Wellsteed, 1965;Stern and Williams, 1966;Menser, Dorman, Reye, and Reid, 1966) pathological data have been limited to descriptions of certain organs or tissues as part of larger series of clinical studies (Plotkin, Oski, Hartnett, Hervada, Friedman and Gowing, 1965; Korones, Ainger, Gilles, Roane, Sever, and Fuste, 1965;Cooper, Green, Krugman, Giles, and Mirick, 1965), or to the pathology of abortuses (Tondury and Smith, 1966).…”

Congenital Rubella: Report of Two Cases with Generalized Infection

“…A fairly rapid improvement was observed after administration of corticotrophin. This episode has been interpreted as interstitial pneumonitis, which has been found at necropsy in some cases of congenital rubella (Korones et al, 1965).…”

Population and Clinic Studies of Congenital Heart Disease in Liverpool

“…It has now become possible to culture the rubella virus, and a recent epidemic of a severe form of rubella on the east coast of the United States has enabled the staffs of several of the medical schools to show that from most babies with malformations the virus can be cultured, and that generalized viraemia occurs in many of them (Korones et al, 1965 ;Lindquist et al, 1965 ;Plotkin et al, 1965). At Johns Hopkins attention has been drawn to the fact that so far as the cardiovascular lesions are concerned the sixth aortic arch seems to be the most vulnerable part, whether the time of the maternal infection coincides with or precedes its period of most rapid development (Neill, 1965).…”