Congenital salivary gland anlage tumor: a case series and review of the literature

Herrmann, Brian W.; Dehner, Louis P.; Lieu, Judith E. C.

doi:10.1016/j.ijporl.2004.08.014

Cited by 35 publications

(24 citation statements)

References 15 publications

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“…The microscopic and ultrastructural pattern of this benign tumour shows epithelial and mesenchymal components, with tubular and cord like structures composed of cells immunophenotypically compatible with myoepithelium, which expresses a broad spectrum of keratins and epithelial membrane antigens while the stromal component expresses vimentin and smooth muscle actin [18,19]. Only 23 cases have been described in the literature so far, and the studies comparing the nature of the epithelia, myoepithelial cells and stromal components of the SGAT with those of the PA are lacking.…”

Section: Discussionmentioning

confidence: 91%

Pleomorphic Adenoma (Benign Mixed Tumour) of the Minor Salivary Glands of the Upper Lip

Debnath¹,

Adhyapok²

2010

J. Maxillofac. Oral Surg.

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Pleomorphic adenoma is the benign tumor of salivary glands, which originates from the myoepithelial cells and intercalated duct cells. This tumor is more common in major salivary glands. This case report describes a rare and unusual lesion in a 55-year-old female, which was diagnosed as pleomorphic adenoma of the minor salivary glands in the upper lip. The tumor was a circumscribed, submucosal nodule, about 2.0 cm in diameter and was characterized by slow growth and rubbery consistency. Complete excision was performed and the histopathological analysis showed an epithelial salivary gland tumor with islands of plasmacytoid cells, duct like structures, in a variable stroma with chondroid, fibrous and myxoid appearance. No recurrence was observed 1 year after the surgery.

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Section: Discussionmentioning

confidence: 91%

Pleomorphic Adenoma (Benign Mixed Tumour) of the Minor Salivary Glands of the Upper Lip

Debnath¹,

Adhyapok²

2010

J. Maxillofac. Oral Surg.

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“…However, the diagnosis can be delayed up to three months of age. To the best of our knowledge, so far less than 25 cases of this tumor have been reported in the literature [2].…”

Section: Discussionmentioning

confidence: 98%

Newborn with congenital salivary gland anlage tumor presenting with respiratory distress

Swayampakula

Ischander

Zuppan

et al. 2015

International Journal of Pediatric Otorhinolaryngology Extra

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“…3 Congenital SGAT has a male predilection and is a rare cause of neonatal airway obstruction, with approximately 23 previous cases reported in the literature. 4 The mass is midline and is typically attached to the posterior septum or the posterior nasopharyngeal wall by a thin pedicle. Excellent results have been obtained with simple excision, with no reported local recurrences.…”

Section: Discussionmentioning

confidence: 99%

“…Although gadolinium contrast was not given in this case because of the absence of intravenous access, 1 previous case in the literature reported heterogeneous gadolinium enhancement in a SGAT. 4 On the basis of the imaging appearance, the main consideration was a nasal glioma, a more common lesion that consists of disorganized, trapped brain tissue with no intracranial connection. As in the SGAT in our patient, nasal gliomas are typically T1 isointense and T2 iso-hyperintense to brain parenchyma.…”

Section: Discussionmentioning

confidence: 99%

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Salivary Gland Anlage Tumor in a Neonate Presenting with Respiratory Distress: Radiographic and Pathologic Correlation

Mogensen¹,

Lin²,

Chang³

et al. 2008

AJNR Am J Neuroradiol

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SUMMARY:We present a case of congenital salivary gland anlage tumor (SGAT) of the nasal septum in a 2-week-old infant who had difficulty breathing through her nose since birth. CT and MR imaging demonstrated a circumscribed mass within the nasal cavity that did not communicate with the intracranial compartment. Differential diagnosis and clinical significance of recognizing this rare lesion are reviewed. N asal airway obstruction in the neonatal period is a potentially life-threatening condition that can be caused by a wide range of entities including congenital malformations, inflammatory conditions, hamartomas, and tumors. If a nasal mass is identified, then CT and MR imaging is often required to further characterize the mass and assess for intracranial involvement before intervention. Congenital salivary gland anlage tumor (SGAT) is a rare, benign lesion of the nasopharynx that presents with respiratory distress in the first days or weeks of life. Although this rare entity has been reported in the surgical and pediatric literature, its imaging features have not been reported in detail. Case ReportA 2-week-old infant had trouble breathing through her nose since birth. The patient's pediatrician noted some bleeding when passing a catheter through the left naris, and the patient was referred to a pediatric otolaryngologist. A nasal endoscopy revealed a friable mass filling the left nasal cavity at the level of the middle turbinate. The right nasal cavity was narrowed because of a severe right septal deviation.CT without contrast enhancement showed a soft tissue attenuation mass centered within the left nasal cavity with benign-appearing bony remodeling of the ethmoid labyrinth. A connection between the mass and the intracranial contents could not be excluded because of normal lack of ossification of the skull base at this age. An MR imaging examination was then performed and demonstrated a well-defined mass filling the posterior left nasal cavity that was T1 isointense and T2 iso-hyperintense to the brain parenchyma, with an intact skull base and no evidence of intracranial communication (Fig 1A-C).The patient underwent CT-guided endoscopic resection of the mass, which was found to be pedicled to an approximately 4-mm area of the nasal septum. The choana and nasopharynx were clear.The fragmented tissue measured 3.0 ϫ 2.3 ϫ 0.8 cm in aggregate. Microscopic examination revealed an overlying nonkeratinized squamous cell lining with foci of mucosal erosions. Nests of epithelial cells arranged as cords, and ductal and solid structures extended from the mucosal layer into an edematous submucosa. The ductlike structures contained foci of squamous differentiation surrounded by round and spindled stromal cells (Fig 2). Cellular pleomorphism and mitotic figures were absent. No neural, glial, or rhabdomyomatous differentiation was present. These findings were compatible with an SGAT. DiscussionThe term SGAT was first used in the literature by Dehner et al 1 in 1994. They reported 9 cases of SGATs within the nasopharynx, al...

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Congenital salivary gland anlage tumor: a case series and review of the literature

Cited by 35 publications

References 15 publications

Pleomorphic Adenoma (Benign Mixed Tumour) of the Minor Salivary Glands of the Upper Lip

Pleomorphic Adenoma (Benign Mixed Tumour) of the Minor Salivary Glands of the Upper Lip

Newborn with congenital salivary gland anlage tumor presenting with respiratory distress

Salivary Gland Anlage Tumor in a Neonate Presenting with Respiratory Distress: Radiographic and Pathologic Correlation

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