Congenital spinal tuberculosis associated with asymptomatic endometrial tuberculosis: A rare case report

Kumar, Ashok; Ghosh, Shanti; Varshney, Manish Kumar; Trikha, Vivek; Khan, Shah Alam

doi:10.1016/j.jbspin.2007.06.015

Cited by 10 publications

(7 citation statements)

References 5 publications

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“…Sometimes, ingested tubercle bacilli enter the Eustachian tubes, leading to TB of the middle ear. Endometrial TB can be an important cause of congenital TB in India and other low‐resource countries 81–85 . More often the newborn acquires infection after birth from the untreated mother or other adult reservoirs in the family or surroundings.…”

Section: Resultsmentioning

confidence: 99%

“…Endometrial TB can be an important cause of congenital TB in India and other low-resource countries. [81][82][83][84][85] More often the newborn acquires infection after birth from the untreated mother or other adult reservoirs in the family or surroundings. In clinical practice, it is difficult to identify the exact route of transmission of TB from mother to baby, so as to establish the diagnosis as congenital or neonatal.…”

Section: Perinatal Tbmentioning

confidence: 99%

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Tuberculosis in pregnancy: The challenges for South Asian countries

Jana

Barik²,

Arora

et al. 2012

J of Obstet and Gynaecol

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Abstractj og_1856 1125..1136Aim: Despite tuberculosis (TB) being a global problem, maternal TB remains an unrecognized and underestimated tragedy, especially in South Asian countries. Therefore, we performed a non-systematic review regarding implications of maternal TB on obstetric and perinatal outcomes in the South Asian context. Material and Methods:We reviewed original studies, both descriptive and analytical, that originated from South Asian countries following an electronic search supplemented by a manual search. Although relevant studies from developed countries were reviewed, they were not included in the tabulation process because those studies had different socioeconomic/epidemiological background. Results: Diagnosis of TB is often delayed during pregnancy, because of its non-specific symptoms, and overlapping presentation with other infectious diseases. Poverty, undernutrition, lack of social support and poor health infrastructure along with complications of TB and need for prolonged medications lead to increased maternal morbidity and mortality. Maternal TB in general (except lymphadenitis), is associated with an increased risk of small-for-gestational age, preterm and low-birthweight neonates, and high perinatal mortality. These adverse perinatal outcomes are even more pronounced in women with advanced disease, late diagnosis, and incomplete or irregular drug treatment. There could be a synergy of TB, socioeconomic and nutritional factors, which might have contributed to adverse perinatal effects, especially in low-income countries. Conclusions: As active TB poses grave maternal and perinatal risks, early, appropriate and adequate anti-TB treatment is a mainstay for successful pregnancy outcome. The current knowledge gaps in perinatal implications of maternal TB can be addressed by a multicenter comparative cohort study.

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Section: Resultsmentioning

confidence: 99%

Section: Perinatal Tbmentioning

confidence: 99%

Tuberculosis in pregnancy: The challenges for South Asian countries

Jana

Barik²,

Arora

et al. 2012

J of Obstet and Gynaecol

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“…Age at presentation may range from very premature neonates 15 to infants up to 3 months of age. 16 Other unusual presentations include spinal tuberculosis, 17 mediastinal lymphadenopathy and cutaneous tuberculosis. 18 Isolation of M. tuberculosis in the infant is mandatory for the diagnosis of congenital/ perinatal tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

Perinatal tuberculosis: four cases and use of broncho‐alveolar lavage

Parakh

Saxena

Thapa

et al. 2011

Annals of Tropical Paediatrics

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Despite the high prevalence of tuberculosis in adults and children, congenital and perinatal forms of tuberculosis are rare. Four patients with perinatal tuberculosis are described. Diagnosis was made by demonstration of acid-fast bacilli (AFB) on broncho-alveolar lavage (BAL) specimens (two cases), gastric aspirate smear (one case) and lymph node fine-needle aspirate (one case). All of the above specimens were subsequently positive on culture. Two infants died of progressive pulmonary failure, and one of the mothers died, despite the institution of anti-tuberculous therapy. BAL specimen examination for AFB is useful in the diagnosis of perinatal tuberculosis, especially in infants with smear-negative gastric aspirate.

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“…[11] In our country, it is seen in the first decade in 50% of cases and is encountered in only 25% cases after 20 years of age. [9] There have been rare case reports of Pott's spine in infants [12,13] resulting from maternal genitourinary TB.…”

Section: Tubercular Osteomyelitis (Also Called As Pott's Disease)mentioning

confidence: 99%

“…Early TB spondylitis without spinal cord compression or neurological deficits can be treated conservatively (12)(13)(14)(15)(16)(17)(18) mg/kg/day and can adversely affect both vestibular and hearing functions and can cause nephrotoxicity. [17] Spinal TB is the severe extrapulmonary form of TB and the scheduled WHO category-I treatment is 2 months of intensive phase with 4 drugs (HRZE) followed by 4 months of the continuation phase of two (HR) drugs.…”

Section: Treatmentmentioning

confidence: 99%

Pediatric spinal infections

Kumar

Arora

2017

IJNS

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The infections of the spinal axis in children are rare when compared with adults. They encompass a large spectrum of diseases ranging from relatively benign diskitis to spinal osteomyleitis and to the rapidly progressive, rare, and potentially devastating spinal epidural, subdural, and intramedullary spinal cord infections. We present a comprehensive review of the literature pertaining to these uncommon entities, in light of our experience from northern India. The most prevalent pediatric spinal infection in Indian scenario is tuberculosis, where an extradural involvement is more common than intradural. The craniovertebral junction is not an uncommon site of involvement in children of our milieu. The majority of pyogenic infections of pediatric spine are associated with congenital neuro-ectodermal defects such as congenital dermal sinus. The clinico-radiological findings of various spinal infections commonly overlap. Hence the endemicity of certain pathogens should be given due consideration, while considering the differential diagnosis. However, early suspicion, rapid diagnosis, and prompt treatment are the key factors in avoiding neurological morbidity and deformity in a growing child.

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Congenital spinal tuberculosis associated with asymptomatic endometrial tuberculosis: A rare case report

Cited by 10 publications

References 5 publications

Tuberculosis in pregnancy: The challenges for South Asian countries

Tuberculosis in pregnancy: The challenges for South Asian countries

Perinatal tuberculosis: four cases and use of broncho‐alveolar lavage

Pediatric spinal infections

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