Congenital Syphilis After Treatment of MaternalSyphilis With a Penicillin Regimen ExceedingCDC Guidelines

Conover, Craig; Rend, Charles A.; Miller, Gabrielle F.; Schmid, George P.

doi:10.1155/s1064744998000258

Cited by 14 publications

(4 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the recommended penicillin regimen for pregnant women, as many as 14% will experience fetal death, or deliver a baby with clinical evidence of congenital syphilis. 13 Although in these cases it is recommended to be treated with at least two doses of benzathine penicillin 2.4 million units within 1 weeks, the efficacy of this regimen in either preventing or fetal syphilis is unknown. 14 Severely infected fetuses can be aborted even though the mother has been on therapy.…”

Section: Discussionmentioning

confidence: 99%

Pregnancy with Early Latent Syphilis, a reality in 21st century: a case report and literature review

Kurniawati

Rahmatyah²,

Lie³

et al. 2022

MHSJ

View full text Add to dashboard Cite

Syphilis is a sexually transmitted disease caused by the spirochete Treponema pallidum. It is of special concern during pregnancy because can lead to adverse pregnancy outcomes and congenital syphilis. We retrospectively included female patient with laboratory-confirmed syphilis in East Java. Demographic, pregnancy record, clinical, radiological, laboratory, and treatment data were reviewed from medical record and health of both mother and child book. Clinical characteristics and outcome of patient were described. The patient was 40-year-old multiparous pregnant women was referred to the hospital at 40 weeks of gestation due to early latent syphilis. The patient was diagnosed during the last trimester and had not been treated, but no vulvar and anal genital wart was found. Patient was scheduled to urgent section caesarean but 1 hour after admitted to the hospital, patient had spontaneous delivery. A healthy son was born (3400 g /50 cm, 10 points Apgar score). Due to the lack of documentation regarding treatment of maternal syphilis, crystalline penicillin was administered to the newborn. Screening and early penicillin treatment are the most important factors that can eliminate complications related to the prenatal contagion with Treponema pallidum. Yet despite the lack of treatment or its inappropriate administration, the pregnancy complicated with maternal syphilis may end in a completely different way.

show abstract

Section: Discussionmentioning

confidence: 99%

Pregnancy with Early Latent Syphilis, a reality in 21st century: a case report and literature review

Kurniawati

Rahmatyah²,

Lie³

et al. 2022

MHSJ

View full text Add to dashboard Cite

show abstract

“…Although well-documented foetal and infant treatment failures with penicillin are rare (Conover 1998), there have been reservations raised about the occasional inadequacy of maternal treatment with penicillin of gestational syphilis in preventing congenital syphilis (Rawstron 1991;Zenker 1991;Monif 1994;Stoll 1994;Richardson 2002;Wendel 2002;Saloojee 2004) and of treating congenital syphilis (Beck-Sague 1987;Ikeda 1990). Concerns have also been raised about the adequacy of concentrations in cerebrospinal fluid of penicillin when babies with congenital syphilis are treated with procaine and aqueous penicillin and benzathine penicillin (Speer 1977).…”

Section: Description Of the Interventionmentioning

confidence: 99%

Antibiotic treatment for newborns with congenital syphilis

Walker

Molano-Franco

et al. 2019

Cochrane Database of Systematic Reviews

View full text Add to dashboard Cite

BackgroundCongenital syphilis continues to be a substantial public health problem in many parts of the world. Since the first use of penicillin for the treatment of syphilis in 1943, which was a notable early success, it has remained the preferred and standard treatment including for congenital syphilis. However, the treatment of congenital syphilis is largely based on clinical experience and there is extremely limited evidence on the optimal dose or duration of administration of penicillin or the use of other antibiotics. ObjectivesTo assess the e ectiveness and safety of antibiotic treatment for newborns with confirmed, highly probable and possible congenital syphilis. Search methodsWe searched the Cochrane STI Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, WHO ICTRP, ClinicalTrials.gov and Web of Science to 23 May 2018. We also handsearched conference proceedings, contacted trial authors and reviewed the reference lists of retrieved studies. Selection criteriaRandomised controlled trials (RCTs) comparing antibiotic treatment (any concentration, frequency, duration and route) with no intervention or any other antibiotic treatment for neonates with confirmed, highly probable or possible congenital syphilis. Data collection and analysisAll review authors independently assessed trials for inclusion, extracted data and assessed the risk of bias in the included studies. We resolved any disagreements through consensus. We assessed the quality of the evidence using the GRADE approach. Main resultsTwo RCTs (191 participants) met our inclusion criteria and none of these trials was funded by the industry. One trial (22 participants) compared benzathine penicillin with no intervention for infants with possible congenital syphilis. Low-quality evidence suggested that benzathine penicillin administration may not have decreased the rate of neonatal death due to any cause (risk ratio (RR) 0.83, 95% confidence interval (CI) 0.06 to 11.70), and showed a possible reduction into the proportion of neonates with clinical manifestations of congenital syphilis (RR 0.12, 95% CI 0.01 to 2.09). Penicillin administration increased the serological cure at the third month (RR 2.13, 95%Antibiotic treatment for newborns with congenital syphilis (Review)

show abstract

“…However, despite receiving a single-dose penicillin regimen, as many as 14% of women with secondary syphilis in late pregnancy will still have a fetal death or deliver an infant with congenital syphilis. 7 All infants born to women with syphilis should be evaluated for congenital infection based on interpretation of paired mother-infant serologic tests and in the context of maternal history (i.e., stage of syphilis, treatment details, and serologic response).…”

Section: Case Studymentioning

confidence: 99%

Congenital Syphilis Masquerading as Leukemia

Lee

Bell

Scimeme

et al. 2017

AJP Rep

View full text Add to dashboard Cite

As of late, the incidence of congenital syphilis in the United States is increasing. Each new case represents a failure of preventing, diagnosing, and treating syphilis in pregnant women. Pediatricians should confirm that all women have received adequate screening for and management of syphilis during pregnancy. Congenital syphilis is easily treatable but may be a diagnostic challenge with high morbidity and mortality.

show abstract

Congenital Syphilis After Treatment of MaternalSyphilis With a Penicillin Regimen ExceedingCDC Guidelines

Abstract: Background." Although congenital syphilis usually occurs as a result of a failure to detect and treat syphilis in pregnant women, failures of the currently recommended regimen to prevent congenital syphilis have been reported.

Cited by 14 publications

References 7 publications

Pregnancy with Early Latent Syphilis, a reality in 21st century: a case report and literature review

Pregnancy with Early Latent Syphilis, a reality in 21st century: a case report and literature review

Antibiotic treatment for newborns with congenital syphilis

Congenital Syphilis Masquerading as Leukemia

Contact Info

Product

Resources

About