Congenital Syphilis

Cooper, Joshua M.; Williams, Jessica E.P.; Sánchez, Pablo J.

doi:10.1007/978-3-319-90038-4_19

Cited by 6 publications

(7 citation statements)

References 19 publications

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“…neonatal death, and significant morbidity in infants (eg, bone deformities and neurologic impairment). 1 After a steady decline from 2008 to 2012, cases of congenital syphilis markedly increased from 2012 to 2016, from 8.4 to 15.7 cases per 100 000 live births (an increase of 87%). 2 At the same time, national rates of syphilis increased among women of reproductive age.…”

mentioning

confidence: 99%

Screening for Syphilis Infection in Pregnant Women

Force¹,

Curry

Krist

et al. 2018

JAMA

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confidence: 99%

Screening for Syphilis Infection in Pregnant Women

Force¹,

Curry

Krist

et al. 2018

JAMA

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“…[7][8][9][10][11][12] Our patient had other findings consistent with congenital syphilis including hepatosplenomegaly, anemia, jaundice, thrombocytopenia, osteitis, and neurosyphilis. 2 Other symptoms that might be seen in congenital syphilis, but are absent in our patient, include rhinitis (snuffles) with mucopurulent nasal discharge, chorioretinopathy, glaucoma, cataracts, interstitial keratitis, saddle nose, frontal bossing due to periostitis, tibial thickening (saber shins), joint swelling (Clutton joints), abnormal tooth development (Hutchinson's teeth, mulberry molars), interstitial keratitis, neurologic deafness, and optic atrophy. 2 In addition, radiographic imaging may reveal osteochondritis, diaphyseal osteomyelitis, and periostitis.…”

Section: Discussionmentioning

confidence: 58%

“…2 Other symptoms that might be seen in congenital syphilis, but are absent in our patient, include rhinitis (snuffles) with mucopurulent nasal discharge, chorioretinopathy, glaucoma, cataracts, interstitial keratitis, saddle nose, frontal bossing due to periostitis, tibial thickening (saber shins), joint swelling (Clutton joints), abnormal tooth development (Hutchinson's teeth, mulberry molars), interstitial keratitis, neurologic deafness, and optic atrophy. 2 In addition, radiographic imaging may reveal osteochondritis, diaphyseal osteomyelitis, and periostitis. 2 All the reported cases on congenital bullous syphilis used serological testing to confirm the diagnosis of syphilis.…”

Section: Discussionmentioning

confidence: 58%

“…2 In addition, radiographic imaging may reveal osteochondritis, diaphyseal osteomyelitis, and periostitis. 2 All the reported cases on congenital bullous syphilis used serological testing to confirm the diagnosis of syphilis. [7][8][9][10][11][12] Three of the cases included additional diagnostic testing by biopsy of a skin lesion with subsequent treponemal IHC for the detection of T. pallidum spirochetes.…”

Section: Discussionmentioning

confidence: 99%

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Congenital bullous syphilis in a newborn: A novel approach to diagnosis using immunohistochemical staining on a blister roof

Ekeh

Duffy

Feingold

et al. 2023

Pediatric Dermatology

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We describe a rare presentation of congenital bullous syphilis in a premature neonate born with extensive skin desquamation. The newborn was noted to have diffuse erythema with widespread, superficial skin desquamation in addition to plantar bullae and erosions, and an absence of mucosal involvement. Immunohistochemical syphilis diagnostic staining was performed on a blister roof, highlighting a novel diagnostic approach for congenital bullous syphilis.

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“…4 7 Untreated infants may also present with late congenital syphilis, after 2 years of age, characterized by chronic inflammation of joints, bones, teeth (Hutchinson's teeth), central nervous system and eyes, and eighth nerve deafness. 4 8…”

Section: Introductionmentioning

confidence: 99%

Is Congenital Syphilis Still a Problem?—A 20-Year Retrospective Study from a Northern Portuguese Level II Hospital

Figueiredo,

Quintela,

Cascais

et al. 2023

J Pediatr Infect Dis

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Objective The incidence of syphilis and congenital syphilis has increased in recent years according to European and United States of America official data: indeed, 2019 was the second consecutive year when the number of reported cases has increased. Syphilis is a venereal disease caused by a spirochete, Treponema pallidum. Congenital syphilis is a consequence of maternal T. palidum transmission to a fetus at any stage of maternal disease, via a transplacental pathway or during labor. Methods To investigate the incidence, characteristics, and temporal evolution of neonates with suspected congenital syphilis (proven, possible, or less likely and unlikely) or born from mothers with treated and untreated latent syphilis, we designed a retrospective and descriptive study of hospitalized neonates between 2001 and 2020, in a level II hospital located in the northern Portuguese countryside. Results We report a total of 22 neonates, 50% female. Pregnancy was unsupervised or had inadequate surveillance in 36% of cases (n = 8), in 32% (n = 7) syphilis was not treated, and in 14% (n = 3) it was inadequately treated. All neonates studied with suspected congenital syphilis were asymptomatic and all were treated with penicillin for a mean duration of 11 days. Of the 22 neonates with suspected congenital syphilis, 20 had possible congenital infection. Social vulnerability was also an important factor present in our study group. Conclusion Despite being an ancient disease, congenital syphilis is still a concern mostly due to the lack of adequate pregnancy surveillance and maternal/partner diagnosis and treatment.

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Congenital Syphilis

Cited by 6 publications

References 19 publications

Screening for Syphilis Infection in Pregnant Women

Screening for Syphilis Infection in Pregnant Women

Congenital bullous syphilis in a newborn: A novel approach to diagnosis using immunohistochemical staining on a blister roof

Is Congenital Syphilis Still a Problem?—A 20-Year Retrospective Study from a Northern Portuguese Level II Hospital

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