Congenital syphilis in the twenty-first century: an area-based study

Salomè, Serena; Cambriglia, Maria Donata; Scarano, Sara Maria; Capone, Eleonora; Betts, Ivy; Pacella, Daniela; Sansone, Matilde; Mazzarelli, Laura Letizia; Vecchio, Andrea Lo; Ranucci, Giusy; Marinosci, Geremia Zito; Capasso, Letizia; Salvatore, Paola; Raimondi, Francesco

doi:10.1007/s00431-022-04703-5

Cited by 23 publications

(21 citation statements)

References 19 publications

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“…[16][17][18][19] Likewise, in Italy, Salomè et al reported no maternal treatment in 27% of congenital syphilis cases, drug abuse in 2.5%, and other sexually transmitted diseases in 6.8%. 20 Most sexual partners were not treated and, although the reasons for this have been little studied, the main reasons are likely social stigma and resistance to comply with treatment. 6,19 As our study demonstrated, the diagnosis and treatment compliance in mothers and their partners remain important factors that could be overcome with the implementation of more effective strategies to promote partners' treatment adherence and minimize social stigma, such as sending electronic prescription codes (through SMS or applications) that allow anonymous treatment in health facilities.…”

Section: Discussionmentioning

confidence: 99%

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Is Congenital Syphilis Still a Problem?—A 20-Year Retrospective Study from a Northern Portuguese Level II Hospital

Figueiredo,

Quintela,

Cascais

et al. 2023

J Pediatr Infect Dis

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Objective The incidence of syphilis and congenital syphilis has increased in recent years according to European and United States of America official data: indeed, 2019 was the second consecutive year when the number of reported cases has increased. Syphilis is a venereal disease caused by a spirochete, Treponema pallidum. Congenital syphilis is a consequence of maternal T. palidum transmission to a fetus at any stage of maternal disease, via a transplacental pathway or during labor. Methods To investigate the incidence, characteristics, and temporal evolution of neonates with suspected congenital syphilis (proven, possible, or less likely and unlikely) or born from mothers with treated and untreated latent syphilis, we designed a retrospective and descriptive study of hospitalized neonates between 2001 and 2020, in a level II hospital located in the northern Portuguese countryside. Results We report a total of 22 neonates, 50% female. Pregnancy was unsupervised or had inadequate surveillance in 36% of cases (n = 8), in 32% (n = 7) syphilis was not treated, and in 14% (n = 3) it was inadequately treated. All neonates studied with suspected congenital syphilis were asymptomatic and all were treated with penicillin for a mean duration of 11 days. Of the 22 neonates with suspected congenital syphilis, 20 had possible congenital infection. Social vulnerability was also an important factor present in our study group. Conclusion Despite being an ancient disease, congenital syphilis is still a concern mostly due to the lack of adequate pregnancy surveillance and maternal/partner diagnosis and treatment.

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Section: Discussionmentioning

confidence: 99%

“…16 17 18 19 Likewise, in Italy, Salomè et al reported no maternal treatment in 27% of congenital syphilis cases, drug abuse in 2.5%, and other sexually transmitted diseases in 6.8%. 20…”

Section: Discussionmentioning

confidence: 99%

Is Congenital Syphilis Still a Problem?—A 20-Year Retrospective Study from a Northern Portuguese Level II Hospital

Figueiredo,

Quintela,

Cascais

et al. 2023

J Pediatr Infect Dis

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“…Actualmente, no existen alternativas para la penicilina G benzatínica en el tratamiento de la sífilis durante el embarazo. A las madres alérgicas a la penicilina, se les recomienda la desensibilización seguida del tratamiento definitivo; previo a usar tratamientos de segunda elección o alternativos (Shah, 2022;Fang, 2022;Sandhu, 2022;Rocha, 2022, Salomè, 2022. P á g i n a 3319 Esquema alternativo:…”

Section: Tratamientounclassified

“…Todos los recién nacidos con un VDRL positivo al nacer que reciben tratamiento, deben continuar con el mismo ambulatoriamente cada 2 a 3 meses, hasta que la prueba resulte negativa. Otras recomendaciones son realizar valoración los meses 1,3,6,9 y 12 de vida, con su respectiva evaluación clínica (Brenes, 2022;Sandhu, 2022;Salomè, 2022).…”

Section: Vigilancia Y Seguimiento En El Paciente Con Sífilisunclassified

Sífilis congénita: Diagnóstico, tratamiento y prevención oportuna, en México.

et al. 2023

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Objetivo: Desarrollo de material de consulta para el diagnóstico, tratamiento y prevención oportuna de la Sífilis tanto gestacional y congénita en México, con el fin de aplicar las recomendaciones y actualizaciones de esta enfermedad de transmisión sexual. Métodos: En este proyecto se revisaron bibliografías de estudios científicos, artículos, reportes de caso, además de documentos legales nacionales e internacionales, con el fin de recabar la información relevante y actual. Resultados: Sífilis es una enfermedad sistémica causada por la bacteria de tipo espiroqueta Treponema Pallidum de evolución crónica y muchas veces asintomática. Es transmitida por vía sexual o materno fetal, por lo cual se determina como adquirida o congénita. En México la sífilis congénita sigue siendo un problema de salud pública, aunque es una enfermedad prevenible y tratable. Conclusión: Hoy en día, la sífilis se considera una patología estrechamente controlada. Sin embargo, se ha observado un incremento significativo de casos, a pesar de la disponibilidad generalizada de tratamiento base. Se debe ser objetivo al identificar las fallas en la asistencia prestada a las embarazadas durante su atención prenatal, para así mejorar la calidad de los servicios de salud en favor del bienestar de la madre y el feto, evitando las complicaciones asociadas como: parto pretérmino, bajo peso al nacer, muerte fetal intrauterina y muerte neonatal, entre otros.

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“…CS primarily affects newborns and infants, posing a substantial health risk. It can result in severe complications, such as neurological disorders, developmental delays, organ damage, and even death [19]. Timely diagnosis and prompt treatment play a critical role in improving outcomes and preventing long-term adverse effects.…”

Section: Classifying Congenital Syphilismentioning

confidence: 99%

The use of Convolutional Neural Network to classify Congenital Syphilis with image representations of tabular data

Neto,

Endo

2023

Preprint

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Purpose: Convolutional Neural Network (CNN) is a powerful Deep Learning (DL) model used in healthcare for diseases classification through image analysis. Although primarily designed for image data, CNNs can be used with tabular data by converting it into images format. This work aims to assess the performance of CNNs in classifying cases of Congenital Syphilis (CS) using images generated from tabular data, and to compare their performance with Machine Learning (ML) models. Methods: We compare different converters for transforming tabular data into images, selecting the most effective one based on the highest CNN metric outcomes. We perform hyperparameter optimization on the best CNN model using Random Search, and compare its performance against an optimized ML model, the Adaboost, proposed in a previous work. Results: We find that it is possible to classify CS with images generated from tabular data of medical records. Additionally, after optimized, the CNN is capable of achieving competitive classification outcomes against an optimized Adaboost, implying their potential utility in medical data analysis. Conclusion: This study demonstrates CNNs’ potential to classify CS cases using images from tabular medical data. The comparison with an optimized Adaboost showcases CNNs’ viability for medical data analysis, showcasing their adaptability beyond image analysis in structured healthcare data. The work limitations include the limited number of converters, the absence of a computational cost analysis, the focus on 2D CNNs only, and the absence of a rigorous statistical significance assessment.

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Congenital syphilis in the twenty-first century: an area-based study

Cited by 23 publications

References 19 publications

Is Congenital Syphilis Still a Problem?—A 20-Year Retrospective Study from a Northern Portuguese Level II Hospital

Is Congenital Syphilis Still a Problem?—A 20-Year Retrospective Study from a Northern Portuguese Level II Hospital

Sífilis congénita: Diagnóstico, tratamiento y prevención oportuna, en México.

The use of Convolutional Neural Network to classify Congenital Syphilis with image representations of tabular data

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