Congenital talipes equinovarus: an epidemiological study in Sicily

Pavone, Vito; Bianca, Sebastiano; Grosso, Giuseppe; Pavone, Piero; Mistretta, Antonio; Longo, Maria Roberta; Marino, Simona Domenica; Sessa, Giuseppe

doi:10.3109/17453674.2012.678797

Cited by 38 publications

(41 citation statements)

References 28 publications

(28 reference statements)

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“…The prevalence of congenital clubfoot in our study was comparable with those observed in other European population‐based studies: 1.03 per 1,000 livebirths in Sicily (Pavone et al, ) and 1.1 per 1,000 livebirths in Norway (Dodwell, Risoe, & Wright, ). However, the recorded prevalence of congenital clubfoot in our study was lower compared to 1.4 per 1,000 livebirths for isolated congenital clubfoot found in a study in Sweden (Wallander, Hovelius, & Michaelsson, ), 1.8 per 1,000 livebirths for all congenital clubfoot cases and 1.1 per 1,000 births for isolated congenital clubfoot in a study in Southern Australia (Byron‐Scott et al, ), 1.14 per 1,000 livebirths for isolated congenital clubfoot in Iowa (Kancherla et al, ) and 1.29 per 1,000 livebirths pooling 10 birth defects surveillance programs in the US (Parker et al, ).…”

Section: Discussionsupporting

confidence: 91%

Congenital clubfoot in Europe: A population‐based study

Wang¹,

Barišić

Loane³

et al. 2019

American J of Med Genetics Pt A

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We aimed to assess prevalence, birth outcome, associated anomalies and prenatal diagnosis of congenital clubfoot in Europe using data from the EUROCAT network, and to validate the recording of congenital clubfoot as a major congenital anomaly by EUROCAT registries. Cases of congenital clubfoot were included from 18 EUROCAT registries covering more than 4.8 million births in 1995-2011. Cases without chromosomal anomalies born during 2005-2009, were randomly selected for validation using a questionnaire on diagnostic details and treatment. There was 5,458 congenital clubfoot cases of which 5,056 (93%) were liveborn infants. Total prevalence of congenital clubfoot was 1.13 per 1,000 births (95% CI 1.10-1.16). Prevalence of congenital clubfoot without chromosomal anomaly was 1.08 per 1,000 births (95% CI 1.05-1.11) and prevalence of isolated congenital clubfoot was 0.92 per 1,000 births (95% CI 0.90-0.95), both with decreasing trends over time and large variations in prevalence by registry. The majority of cases were isolated congenital clubfoot (82%) and 11% had associated major congenital anomalies. Prenatal detection rate of isolated congenital clubfoot was 22% and increased over

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Section: Discussionsupporting

confidence: 91%

Congenital clubfoot in Europe: A population‐based study

Wang¹,

Barišić

Loane³

et al. 2019

American J of Med Genetics Pt A

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“…Orthopaedic conditions commonly present bilaterally [1,6,14,19]. In clinical trials, data from each limb are commonly treated as independent [10,13].…”

Section: Discussionmentioning

confidence: 99%

“…Orthopaedic conditions, such as clubfoot often present bilaterally [1,4,6,14,19]. Orthopaedic research commonly involves analysis of populations of patients with bilateral presentations.…”

Section: Introductionmentioning

confidence: 99%

Bilateral Clubfeet Are Highly Correlated: A Cautionary Tale for Researchers

Gray

Gibbons

Little

et al. 2014

Clinical Orthopaedics &Amp; Related Research

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Background Congenital talipes equinovarus, or clubfoot, is a common pediatric orthopaedic condition of unknown origin. In many clubfoot clinical trials, interventions are assigned to a patient, but response to treatment is assessed separately in each foot. Trials commonly report x patients with y feet where y is greater than x (eg, 35 patients with 56 feet). However, common statistical tests assume that each data point is independent. Although data from unilateral cases of clubfoot are independent, it is unknown if each foot of patients with bilateral clubfeet are correlated. Questions/purposes The purpose of this study was to assess the correlation in the feet of patients with bilateral clubfeet by (1) evaluating the degree of severity between lower limbs of each patient with bilateral clubfeet at baseline; (2) determining if right and left feet of each patient responded to intervention in the same way; (3) determining the proportion of bilateral relapse; and (4) determining the proportion of right and left feet which required the same intervention to correct bilateral relapse. Methods We performed a chart review of the records of 33 patients with bilateral clubfeet (66 feet). Baseline severity was assessed using the Pirani score. The number of Ponseti serial casts to correct the deformity, the proportion of patients who underwent bilateral Achilles tenotomy, the proportion of bilateral relapse, and the treatment to correct bilateral relapse were examined. Results The degree of severity between right (Pirani score mean, 5.2; SD, 0.8) and left (Pirani score mean, 5.2; SD, 0.5) feet for each patient at baseline was highly correlated (r = 0.76, p \ 0.001). Response to intervention between lower limbs was highly correlated for the number of Ponseti casts required for initial correction (right mean, 5.2, SD, 1.1; left mean, 5.2, SD, 1.3) (r = 0.89, p \ 0.001) and the proportion of patients who underwent bilateral Achilles tenotomy (right, 17/18; left, 16/18) (r = 0.94, p \ 0.001). In the nine patients who experienced relapse, eight experienced bilateral involvement. In all cases of bilateral relapse, the right and left foot of each patient required the same intervention to correct the relapse. Conclusions In patients with bilateral clubfeet, baseline severity, response to initial Ponseti treatment, Achilles tenotomy, and relapse outcomes were highly correlated in

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“…Epidemiologic studies have consistently reported higher prevalence of idiopathic clubfoot in males and firstborn but any associations with smoking, race/ ethnicity and maternal age are not clear (Cardy et al, 2007;Dickinson et al, 2008;Kancherla et al, 2010;Pavone et al, 2012). These studies are very scanty in Nigeria and to the best of our knowledge no study has focused on idiopathic clubfoot in our country.…”

Section: Introductionmentioning

confidence: 73%

“…Some studies differ in opinion in that they found no association (Werler et al, 2013;Pavone et al, 2012;Carey et al, 2005;Skelly et al, 2002).…”

Section: Discussionmentioning

confidence: 90%

Descriptive epidemiology and predisposing factors to idiopathic talipes equinovarus in South South Nigeria

Asuquo¹,

Innocent²,

Anisi³

et al. 2016

J. Public Health Epidemiol.

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Talipes equinovarus (Clubfoot) is the commonest foot deformity with variable incidence across races. Exact etiology remains elusive. The objective of this study is to describe the epidemiology of clubfoot in our centre, looking for predisposing factors. This is a descriptive clinic based epidemiologic study of 106 feet belonging to 69 subjects from January 2014 -December 2015 was conducted. Structured questionnaires were administered to clinically confirmed clubfoot subject's guardian or biologic mothers. Phenotypic data from clubfoot subject were also recorded. Analysis was done using IBM SPSS version 22 for windows. Results revealed the age range of the patients as 3 days to 9 years, with a mean age of 46.17 ± 92.03 weeks. Thirty-seven (53.7%) patients had bilateral deformity while 13 (18.8%) patients had right-sided deformity, and 19 (27.5%) patients had left-sided deformity. Majority 40 (58.0%) of the patients were firstborn out of which 28 were males. Only 2 (2.89%) patients are products of multiple gestations. All mothers were none smokers and there was no reported family history of foot deformities or clubfoot. The mean maternal age was 25.81 years ± 4.99 years. The average length/height of patients at presentation was 64.27 ± 23.93 cm. The average shoulder span of the patients at presentation was 23.93 ± 15.86 cm. The study thus revealed that young maternal age, gender and firstborn are predisposing factors in the etiology of clubfoot.

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Congenital talipes equinovarus: an epidemiological study in Sicily

Cited by 38 publications

References 28 publications

Congenital clubfoot in Europe: A population‐based study

Congenital clubfoot in Europe: A population‐based study

Bilateral Clubfeet Are Highly Correlated: A Cautionary Tale for Researchers

Descriptive epidemiology and predisposing factors to idiopathic talipes equinovarus in South South Nigeria

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