Congenital thrombophilia in East-Asian venous thromboembolism population: a systematic review and meta-analysis

Zhu, Xi‐Jie; Liu, Ziyi; Wang, Pei‐Wen; Wang, Jia; Wen, Sijia; Zhang, Jie-Xin; Zhu, Yongjian; Sun, Ming-Li; Xu, Xiequn; Sun, Ke; Lian, Tian‐Yu; Chen, Cheng; Jing, Zhi-Cheng

doi:10.1016/j.rpth.2023.102157

Cited by 4 publications

(1 citation statement)

References 56 publications

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“…The authors also acknowledge that they did not analyse for other common mutations in anti-thrombin III protein (SERPINC1), protein C (PROC) and protein S (PROS1) given the relative rarity of such mutations. I would like to highlight that these mutations are relatively common in the Asian population compared to F5/F2 mutations, with a recent meta-analysis by Zhu et al [ 7 ] demonstrating the prevalence of PROC, PROS1 and SERPINC1 deficiency at 7.1%, 8.3% and 3.8% respectively in East Asian patients with VTE. This reiterates the need to validate the PGS model in other ethnic populations, as well as its performance against regionally prevalent thrombophilia mutations.…”

Section: To the Editormentioning

confidence: 99%

Genetic risk stratification of inflammatory bowel disease-associated venous thromboembolism: An Asian perspective

Huang

2024

World J Gastroenterol

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Section: To the Editormentioning

confidence: 99%

Genetic risk stratification of inflammatory bowel disease-associated venous thromboembolism: An Asian perspective

Huang

2024

World J Gastroenterol

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Clinical prediction tool to identify children at risk of pulmonary embolism

Tiratrakoonseree,

Charoenpichitnun,

Natesirinilkul

et al. 2024

Thrombosis Research

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Safety and efficacy of extended thrombophilia screening directed venous thromboembolic events (VTE) prophylaxis in live liver donors: do we really need extended thrombophilia screening routinely?

Dogar,

Hussain,

Ullah

et al. 2024

Annals of Medicine &Amp; Surgery

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Background and aims: The study aimed to determine the prevalence of hereditary thrombophilia, and stratify its severity among live liver donors in Pakistan. Also, we evaluated the safety and efficacy of thrombophilia profile testing directed venous thromboembolic events (VTE) prophylaxis while balancing bleeding risk and the need for routine thrombophilia testing before live liver donation among living donor candidates. Materials & Methods: Protein S (PS), protein C (PC), anti-thrombin (AT) III, and anti-phospholipid antibody panel (APLA) levels were measured in 567 potential donor candidates. Donors were divided into normal, borderline and high-risk groups based on Caprini score. The safety endpoints were VTE occurrence, bleeding complications or mortality. Results: Among 567 donors, 21 (3.7%) were deficient in protein C, and 14(2.5%) were deficient in anti-thrombin-III. IgM & IgG Anti-phospholipids antibodies were positive in 2/567(0.4%) and 2/567(0.4%) respectively. IgM & IgG Lupus anticoagulant antibodies were positive in 3/567(0.5%) and 3/567(0.5%) respectively. VTE events, bleeding complications and post-operative LDLT-related complications were comparable among the three donor groups (P>0.05). One donor in the normal donor group developed pulmonary embolism, but none of the donors in either borderline or high-risk group developed VTE. The mean length of ICU and total hospital stay were comparable. No donor mortality was observed in all donor groups. Conclusions: Due to thrombophilia testing directed VTE prophylaxis, VTE events were comparable in normal, borderline and high-risk thrombophilia donor groups, but more evaluations are required to determine the lower safe levels for various thrombophilia parameters including PC, PS and AT-III before surgery among living donor candidates.

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Congenital thrombophilia in East-Asian venous thromboembolism population: a systematic review and meta-analysis

Cited by 4 publications

References 56 publications

Genetic risk stratification of inflammatory bowel disease-associated venous thromboembolism: An Asian perspective

Genetic risk stratification of inflammatory bowel disease-associated venous thromboembolism: An Asian perspective

Clinical prediction tool to identify children at risk of pulmonary embolism

Safety and efficacy of extended thrombophilia screening directed venous thromboembolic events (VTE) prophylaxis in live liver donors: do we really need extended thrombophilia screening routinely?

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