Congenital Transmission of Experimental Leishmaniasis in a Hamster Model

Osorio, Yaneth; Rodriguez, Luz D.; Bonilla, Diana; Peniche, Alex G.; Henao, Hector Hernán; Saldarriaga, Ómar A.; Travi, Bruno L.

doi:10.4269/ajtmh.2012.11-0458

Cited by 21 publications

(21 citation statements)

References 34 publications

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“…Another very delicate condition occurs when pregnant women are affected by VL, because it imposes risks of treatment to the mother and fetus, as well as the possibility of abortion or vertical transmission of the disease 13,22,23 . In Ceará, there was an annual occurrence of VL in pregnant women at approximately 1.9% of patients (in the group of women aged 10 -59 years), which corresponds to approximately 0.65% of the total female cases, with high prevalence in adolescents and young adults (between 10 and 19 years old).…”

Section: Discussionmentioning

confidence: 99%

Epidemiological aspects of visceral leishmaniasis (kala-azar) in Ceará in the period 2007 to 2011

Cavalcante

Vale

2014

Rev. bras. epidemiol.

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INTRODUCTION: Visceral leishmaniasis (VL; kala-azar) is a serious zoonosis that can be lethal, especially in untreated patients. Due to the fact that the State of Ceará is still an important area of transmission of VL, and based on the constant reports of the urbanization process of the disease in the country, it was necessary to monitor the occurrence of cases of leishmaniasis through epidemiological surveillance. OBJECTIVES: To describe the epidemiology of leishmaniasis cases in Ceará, Brazil. METHODS: We conducted an epidemiological survey of secondary data provided by SINAN/MS from January 2007 to December 2011. RESULTS: VL is an endemic disease in the State of Ceará, with cases notified in approximately 88% of the municipalities, with an average of 596.8 ± 29.6 cases, an incidence of 6.1 cases/100,000 inhabitants and prevalence of 7.1 cases/100,000 inhabitants. The Metropolitan Region of Fortaleza is the microregion with the largest number of cases reported in state (51.9% of cases), with the capital, Fortaleza, being the municipality with the highest number of cases in the country. Traditionally, the main age group affected by the disease are children; however, a reversal has been observed in the profile from 2008, when the population of adult patients exceeded the pediatric population. CONCLUSION: Ceará is still an endemic area for VL, and the city of Fortaleza reported the highest number of cases in the country. In the State, a change in the profile of patients with the disease has been observed, now affecting primarily adults.

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Section: Discussionmentioning

confidence: 99%

Epidemiological aspects of visceral leishmaniasis (kala-azar) in Ceará in the period 2007 to 2011

Cavalcante

Vale

2014

Rev. bras. epidemiol.

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“…These results are also in agreement with prior descriptions of cellular infiltration, along with elevated expression of proinflammatory cytokines such as G-CSF, TNF-α, IL-6, IFN-γ, and CXCL9 at the maternal-fetal interface after infection with other bacterial or parasitic pathogens (e.g., Salmonella, Plasmodium, Toxoplasma, or Leishmania spp.) that cause vertical transmission (63)(64)(65)(66)(67)(68)(69)(70)(71).…”

Section: Discussionmentioning

confidence: 99%

CXCR3 blockade protects against Listeria monocytogenes infection–induced fetal wastage

Chaturvedi¹,

Ertelt²,

Jiang³

et al. 2015

J. Clin. Invest.

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“…In addition to genetic factors, acquired characteristics, such as AIDS (reviewed in [47]), preexposure to the parasite in utero [48], malnutrition [49], [50], and youth [51], [52], can also increase the risk of developing symptomatic leishmaniasis. All of these are associated with impaired immune responses against the parasite.…”

Section: Host Determinants Of Visceral Leishmaniasismentioning

confidence: 99%

Determinants for the Development of Visceral Leishmaniasis Disease

2013

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Leishmaniasis is a vector-borne neglected tropical disease associated with a spectrum of clinical manifestations, ranging from self-healing cutaneous lesions to fatal visceral infections. Among the most important questions in Leishmania research is why some species like L. donovani infect visceral organs, whereas other species like L. major remain in the skin. The determinants of visceral leishmaniasis are still poorly understood, although genomic, immunologic, and animal models are beginning to provide important insight into this disease. In this review, we discuss the vector, host, and pathogen factors that mediate the development of visceral leishmaniasis. We examine the progression of the parasite from the initial site of sand fly bite to the visceral organs and its ability to survive there. The identification of visceral disease determinants is required to understand disease evolution, to understand visceral organ survival mechanisms, and potentially to develop better interventions for this largely neglected disease.

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Congenital Transmission of Experimental Leishmaniasis in a Hamster Model

Cited by 21 publications

References 34 publications

Epidemiological aspects of visceral leishmaniasis (kala-azar) in Ceará in the period 2007 to 2011

Epidemiological aspects of visceral leishmaniasis (kala-azar) in Ceará in the period 2007 to 2011

CXCR3 blockade protects against Listeria monocytogenes infection–induced fetal wastage

Determinants for the Development of Visceral Leishmaniasis Disease

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