Congenitally acquired malaria in a hyperendemic area: A cohort study.

Ezechukwu, CC; Ekejindu, Ifeoma Mercy; Ugochukwu, EF; Egbuonu, Ifeoma; Oguatu, M; Chukwuka, JO

doi:10.4314/tjmr.v8i2.30439

Cited by 8 publications

(11 citation statements)

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“…Congenital malaria is defined as malarial parasites demonstrated in the peripheral smear of the newborn within the first twenty four hours to seven days of life 1 . Congenital malaria hitherto thought to be rare is becoming increasingly prevalent.…”

Section: Discussionmentioning

confidence: 99%

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Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Kolawole¹,

Jimoh²,

Babatunde³

et al. 2010

Biokemistri

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A seven month study (March-September 2006) on the prevalence of congenital malaria was carried out at the labour unit of three different hospitals within Ilorin metropolis: Eyitayo Hospital, Surulere Medical Hospital and Children Specialist Hospital Centre Gboro Ilorin. A total of 130 blood samples were collected from the mothers and their newborn babies and examined for malaria parasite using both thin and thick films. Maternal packed cell volume (PCV) and genotype was also determined using haematocrit method and cellulose acetate electrophoresis respectively. The prevalence rate of maternal, fetal, placental and cord parasitaemia were 37(28.46%), 29(22.31%), 33(25.38%) and 30(23.08%) respectively. Malaria infected maternal blood had a mild reduction in PCV level (p<0.05). Genotype showed strong correlation with maternal, fetal, placental and cord parasitaemia (p<0.05). However, the effect of malaria prophylaxis was shown to be more protective for the placental parasitaemia (p<0.05). Finally maternal age and parity did not show strong correlation with Maternal, fetal, placental and cord parasitaemia (p>0.05).

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Section: Discussionmentioning

confidence: 99%

“…Congenital malaria is defined as malarial parasites demonstrated in the peripheral smear of the newborn within the first twenty four hours to seven days of life 1 . This results from malaria parasites crossing the placenta from maternal into the fetal circulation, although the mechanism of transplacental passage is obscure.…”

Section: Introductionmentioning

confidence: 99%

Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Kolawole¹,

Jimoh²,

Babatunde³

et al. 2010

Biokemistri

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“…Indexed African Journals Online: www.ajol.info peripheral smear of the newborn within the first twenty four hours to seven days of life [Ezechukwu et al, 2004]. Congenital malaria hitherto thought to be rare is becoming increasingly prevalent.…”

Section: Congenital Malaria Is Defined As Malarial Parasites Demonstrmentioning

confidence: 99%

“…Congenital malaria is defined as malarial parasites demonstrated in the peripheral smear of the newborn within the first twenty four hours to seven days of life [Ezechukwu et al, 2004]. This results from malaria parasites crossing the placenta from maternal into the fetal circulation, although the mechanism of transplacental passage is obscure.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Congenital Malaria in Ilorin, Nigeria

Kolawole¹,

Jimoh²,

Babatunde³

et al. 2009

Afr. Res. Rev.

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A total of 130 blood samples were collected from the mothers and their newborn babies and examined for malaria parasite using both thin and thick films. Maternal packed cell volume (PCV), and genotype was also determined using haematocrit method and cellulose acetate electrophoresis respectively. The prevalence rate of maternal, fetal, placental and cord parasitaemia were 37(28.46%), 29(22.31%), 33(25.38%) and 30(23.08%) respectively. Malaria infected maternal blood had a mild reduction in PCV level (p<0.05). Genotype showed strong correlation with maternal, fetal, placental and cord parasitaemia (p<0.05). However, the effect of malaria prophylaxis was shown to be more protective for the placental parasitaemia (p<0.

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“…Other means of transmitting the infection are through blood transfusion [1] and congenital transmission [2]. Malaria is the most important of the parasitic diseases of humans, with over 1 billion cases and between 1-3 million deaths each year, most of whom are children below the age of 5 years (CDC).…”

Section: Introductionmentioning

confidence: 99%

Biochemical indices of liver function in malaria patients

Adediji

Adelakun

Motayo

et al. 2015

Int Jour of Biomed Res

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Introduction: Malaria is a tropical disease, which has hepatocellular involvement and is a significant cause of morbidity and mortality especially among children. Objective: This study investigated the biochemical indices of liver function in children infected with malaria and compared their results with healthy children (age and sex-matched). Methodology: Fifty patients (age: 5.1 ± 1.9 years) were enrolled from the Pediatrics' clinic of a tertiary health institution in Ogun state, Nigeria. Fifty age-and sex-matched apparently healthy children, from the same geographical location were selected as control. Examination of a thick blood film was done to confirm the presence of Plasmodium falciparum trophozoite in patients and its absence in controls. The in vitro determination of the plasma activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), plasma total and conjugated bilirubin was performed using standard methods. Data obtained were statistically analyzed using student's t-test where P of less than 0.05 was considered significant. Results: The plasma activities of AST (34 ± 28 vs 10 ± 4 U/L) and plasma levels of total bilirubin (1.1 ± 0.7 vs 0.6 ± 0.2 mg/dL) were significantly higher in malaria patients compared with controls (p < 0.001). There was no significant difference in the plasma activities of ALT and ALP as well as concentration of conjugated bilirubin when compared with controls. Conclusion: This study concluded that abnormal biochemical indices of liver functions observed in malaria patients does not conclusively imply liver disease, it could be as a result of intravascular haemolysis.

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Congenitally acquired malaria in a hyperendemic area: A cohort study.

Cited by 8 publications

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Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Some Biochemical and Haematological Studies on the Prevalence of Congenital Malaria in Ilorin, Nigeria

Prevalence of Congenital Malaria in Ilorin, Nigeria

Biochemical indices of liver function in malaria patients

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