Congestive Heart Failure in Neonatal Thyrotoxicosis

Shapiro, Steven M.; Steier, Moshe; Dimich, Ivan

doi:10.1177/000992287501401209

Cited by 15 publications

(3 citation statements)

References 7 publications

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“…Unlike the other complications of GD, cardiomyopathy is life-threatening and therefore most of the patients who recover from cardiomyopathy are advised to undergo radioactive iodine ablation or thyroidectomy 3 4 5 6) . However, our patient did not undergo thyroidectomy or radioactive iodine ablation.…”

Section: Discussionmentioning

confidence: 99%

“…Although GD has been reported to cause DCMP in adults, the mechanism has not been documented precisely. There have been several reports of adults with DCMP due to GD, as well as of infants with congestive heart failure secondary to transient neonatal thyrotoxicosis 3 4 5 6) . Most of these patients are reported to have recovered completely after a euthyroid state was established, although a few of the adult patients died 5) .…”

Section: Introductionmentioning

confidence: 99%

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Dilated cardiomyopathy with Graves disease in a young child

Choi

Jang

Park

et al. 2016

Ann Pediatr Endocrinol Metab

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Graves disease (GD) can lead to complications such as cardiac arrhythmia and heart failure. Although dilated cardiomyopathy (DCMP) has been occasionally reported in adults with GD, it is rare in children. We present the case of a 32-month-old boy with DCMP due to GD. He presented with irritability, vomiting, and diarrhea. He also had a history of weight loss over the past few months. On physical examination, he had tachycardia without fever, a mild diffuse goiter, and hepatomegaly. The chest radiograph showed cardiomegaly with pulmonary edema, while the echocardiography revealed a dilated left ventricle with an ejection fraction (EF) of 28%. The thyroid function test (TFT) showed elevated serum T3 and decreased thyroid stimulating hormone (TSH) levels. The TSH receptor autoantibody titer was elevated. He was diagnosed with DCMP with GD; treatment with methylprednisolone, diuretics, inotropics, and methimazole was initiated. The EF improved after the TFT normalized. At follow-up several months later, although the TFT results again showed evidence of hyperthyroidism, his EF had not deteriorated. His cardiac function continues to remain normal 1.5 months after treatment was started, although he still has elevated T3 and high TSH receptor antibody titer levels due to poor compliance with drug therapy. To summarize, we report a young child with GD-induced DCMP who recovered completely with medical therapy and, even though the hyperthyroidism recurred several months later, there was no relapse of the DCMP.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dilated cardiomyopathy with Graves disease in a young child

Choi

Jang

Park

et al. 2016

Ann Pediatr Endocrinol Metab

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“…10,11 Fetal thyrotoxicosis is manifested by tachycardia and hyperkinesia and may be complicated by congestive heart failure. 12,13 In heart failure, chylothorax may be produced by an increase in lymph production secondary to an augmented pulmonary capillary filtration associated with an obstruction to lymphatic flow caused by increased pressure in the left subclavian vein. 14, 15 Moreno et al 16 reported an adult case of bilateral pleural effusions resulting from thyrotoxicosis without associated heart failure.…”

Section: Discussionmentioning

confidence: 99%

Congenital Chylothorax in Neonatal Thyrotoxicosis

et al. 1999

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We report a patient with congenital chylothorax who also had neonatal thyrotoxicosis secondary to maternal Graves' disease. Fetal tachycardia with hydrops was detected at 28 weeks' gestational age. The fetus responded to antithyroid medication in utero but had persistent bilateral pleural effusion. At birth, he had respiratory distress due to massive pleural effusion. Cytologic studies of pleural fluid were consistent with chylothorax. To the best of our knowledge, the association of congenital chylothorax with fetal (neonatal) thyrotoxicosis, has not been reported previously.

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Hemodynamic profile of constrictive pericarditis produced by a massive right pleural effusion

Dell’Italia

Walsh

1984

Cathet. Cardiovasc. Diagn.

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We report a 29-year-old female who presented with thyrotoxicosis and a massive right pleural effusion. Cardiac catheterization in the presence of the effusion revealed equalization of abnormally elevated right and left heart filling pressures. Repeat study after thoracentesis demonstrated normal intracardiac pressures, which were unchanged by volume loading with normal saline. This case report suggests that both extrinsic cardiac chamber compression produced by the large unilateral effusion and ventricular interdependence altered diastolic function of the right and left ventricle in a manner resembling constrictive pericarditis or restrictive cardiomyopathy.

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Congestive Heart Failure in Neonatal Thyrotoxicosis

Cited by 15 publications

References 7 publications

Dilated cardiomyopathy with Graves disease in a young child

Dilated cardiomyopathy with Graves disease in a young child

Congenital Chylothorax in Neonatal Thyrotoxicosis

Hemodynamic profile of constrictive pericarditis produced by a massive right pleural effusion

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