Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma

Farrell, Christopher; Shi, Wenyin; Bodman, Alexa; Olson, Jeffrey J.

doi:10.1007/s11060-020-03607-4

Cited by 12 publications

(7 citation statements)

References 241 publications

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“…The use of temozolomide concurrently and after radiotherapy has clearly improved overall survival (7). Results of immunotherapy have been promising in patients with newly diagnosed glioblastoma, although no immunotherapeutic agents are yet available (8). Given these numerous emerging new treatment opportunities, rational selection of the optimal therapeutic strategy for every patient is essential.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical practice guidelines (CPGs) are systematically developed statements supported by a systematic review of evidence to optimize patient care. Recently, many guidelines regarding the neuropathology (9), surgery, radiation therapy, and chemotherapeutic and antiangiogenic treatment on gliomas (8), have emerged or updated due to the growing evidence. The guidelines also addressed the management of gliomas in children (10,11).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the reporting quality of clinical practice guidelines on gliomas using the RIGHT checklist

Yang¹,

Ma²,

Lü³

et al. 2021

Ann Transl Med

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Background: The reporting quality of clinical practice guidelines (CPGs) for gliomas has not yet been thoroughly assessed. The International Reporting Items for Practice Guidelines in Healthcare (RIGHT) statement developed in 2016 provides a reporting framework to improve the quality of CPGs. We aimed to estimate the reporting quality of glioma guidelines using the RIGHT checklist and investigate how the reporting quality differs by selected characteristics.Methods: We systematically searched electronic databases, guideline databases, and medical society websites to retrieve CPGs on glioma published between 2018 and 2020. We calculated the compliance of the CPGs to individual items, domains and the RIGHT checklist overall. We performed stratified analyses by publication year, country of development, reporting of funding, and impact factor (IF) of the journal.Results: Our search revealed 20 eligible guidelines. Mean overall adherence to the RIGHT statement was 54.6%. Eight CPGs reported more than 60% of the items, and five reported less than 50%. All guidelines adhered to the items 1a, 3, 7a, 13a, while no guidelines reported the items 17 or 18b (see http://www.rightstatement.org/right-statement/checklist for a description of the items). Two of the seven domains, "Basic information" and "Background", had mean reporting rates above 60%. The "Review and quality assurance" domain had the lowest mean reporting rate, 12.5%. The reporting quality of guidelines published in 2020, guidelines developed in the United States, and guidelines that reported funding tended to be above average. Conclusions:The reporting quality of CPGs on gliomas is low and needs improvement. Particular attention should be paid on reporting the external review and quality assurance process. The use of the RIGHT criteria should be encouraged to guide the development, reporting and evaluation of CPGs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the reporting quality of clinical practice guidelines on gliomas using the RIGHT checklist

Yang¹,

Ma²,

Lü³

et al. 2021

Ann Transl Med

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“…Radiation therapy represents a core modality of cancer treatment [9]. For instance, it is indicated in newly diagnosed or recurrent glioblastoma [10][11][12] and has gained interest in recent years in the therapeutic algorithm of hepatocellular carcinoma (HCC), notably through stereotactic body radiation therapy [13][14][15][16]. In the case of cutaneous malignant melanoma, radiation therapy is not recommended in current guidelines; however, numerous studies reported its efficacy, notably in the setting of elective adjuvant irradiation for eradicating subclinical of a radioresistance phenotype, and their interaction with methionine dependency as a hallmark of metabolic adaptation in cancer.…”

Section: Introductionmentioning

confidence: 99%

Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

et al. 2021

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Background Although radiation therapy represents a core cancer treatment modality, its efficacy is hampered by radioresistance. The effect of ionizing radiations (IRs) is well known regarding their ability to induce genetic alterations; however, their impact on the epigenome landscape in cancer, notably at the CpG dinucleotide resolution, remains to be further deciphered. In addition, no evidence is available regarding the effect of IRs on the DNA methylome profile according to the methionine dependency phenotype, which represents a hallmark of metabolic adaptation in cancer. Methods We used a case–control study design with a fractionated irradiation regimen on four cancerous cell lines representative of HCC (HepG2), melanoma (MeWo and MeWo-LC1, which exhibit opposed methionine dependency phenotypes), and glioblastoma (U251). We performed high-resolution genome-wide DNA methylome profiling using the MethylationEPIC BeadChip on baseline conditions, irradiated cell lines (cumulative dose of 10 Gy), and non-irradiated counterparts. We performed epigenome-wide association studies to assess the effect of IRs and methionine-dependency-oriented analysis by carrying out epigenome-wide conditional logistic regression. We looked for epigenome signatures at the locus and single-probe (CpG dinucleotide) levels and through enrichment analyses of gene ontologies (GO). The EpiMet project was registered under the ID#AAP-BMS_003_211. Results EWASs revealed shared GO annotation pathways associated with increased methylation signatures for several biological processes in response to IRs, including blood circulation, plasma membrane-bounded cell projection organization, cell projection organization, multicellular organismal process, developmental process, and animal organ morphogenesis. Epigenome-wide conditional logistic regression analysis on the methionine dependency phenotype highlighted several epigenome signatures related to cell cycle and division and responses to IR and ultraviolet light. Conclusions IRs generated a variation in the methylation level of a high number of CpG probes with shared biological pathways, including those associated with cell cycle and division, responses to IRs, sustained angiogenesis, tissue invasion, and metastasis. These results provide insight on shared adaptive mechanisms of the epigenome in cancerous cell lines in response to IR. Future experiments should focus on the tryptic association between IRs, the initiation of a radioresistance phenotype, and their interaction with methionine dependency as a hallmark of metabolic adaptation in cancer. Graphical abstract

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“…1 The achievable extent of resection (EOR) in these cases involving perieloquent lesions is often defined by functional anatomic boundaries rather than gross tumor volume. 1-4 Intraoperative neurophysiological mapping and monitoring (IONMap and IONMon, respectively) remains the gold-standard method to identify anatomic correlates of function, along with monitoring neurological pathways in real time. 5-7…”

mentioning

confidence: 99%

“…1 The achievable extent of resection (EOR) in these cases involving perieloquent lesions is often defined by functional anatomic boundaries rather than gross tumor volume. [1][2][3][4] Intraoperative neurophysiological mapping and monitoring (IONMap and IONMon, respectively) remains the gold-standard method to identify anatomic correlates of function, along with monitoring neurological pathways in real time. [5][6][7] Static IONMap techniques have been widely adopted, whereby the surgeon approximates the location of critical structures based on preoperative imaging and then tests for function using IONMap techniques such as direct cortical or subcortical stimulation (DCS and SCS, respectively).…”

mentioning

confidence: 99%

Adjustable, Dynamic Subcortical Stimulation Technique for Brain Tumor Resection: A Case-Series

Silverstein

Shah

Greisman

et al. 2023

Operative Neurosurgery

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BACKGROUND AND OBJECTIVES: Subcortical stimulation (SCS) is the gold standard neuromonitoring technique for intraoperative identification of descending white matter tracts. Dynamic SCS confers several advantages over more commonly used static devices; however, current commercially available devices for dynamic SCS have not been widely adopted. METHODS: We fashioned a dynamic SCS device using a stainless-steel suction and commonly available materials and assessed its efficacy in a series of 14 patients with brain tumors. The device was used to provide continuous SCS during tumor resection. Preoperative and postoperative motor function were characterized, and preoperative and postoperative imaging were analyzed to determine extent of tumor resection and proximity to motor-eloquent structures. Inferential statistics were used to correlate study parameters. RESULTS: Fourteen patients (12 male and 2 female, median age 52.5 years) were analyzed. The lowest intraoperative SCS intensities were 10 to 15 mA (3 surgeries), 5 to 10 mA (4 surgeries), and <5 mA (2 surgeries). SCS with this device did not elicit motor evoked potentials in 5 surgeries because of distance from the corticospinal tract (CST) and served as negative controls. Three patients (21.4%) experienced new postoperative motor deficits immediately after surgery that resolved by discharge. We observed no instances of mechanical CST injury resulting in permanent postoperative motor deficits using this technique and no correlation between lower SCS intensity and the presence of new motor impairments after surgery. No patient experienced an intraoperative seizure. CONCLUSION: The novel dynamic SCS device is easily adoptable and allows accurate intraoperative identification of the CST, facilitating safe resection of tumors near motor-eloquent structures.

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Congress of neurological surgeons systematic review and evidence-based guidelines update on the role of emerging developments in the management of newly diagnosed glioblastoma

Cited by 12 publications

References 241 publications

Evaluation of the reporting quality of clinical practice guidelines on gliomas using the RIGHT checklist

Evaluation of the reporting quality of clinical practice guidelines on gliomas using the RIGHT checklist

Ionizing radiations induce shared epigenomic signatures unraveling adaptive mechanisms of cancerous cell lines with or without methionine dependency

Adjustable, Dynamic Subcortical Stimulation Technique for Brain Tumor Resection: A Case-Series

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