Congruence of the topography of intracranial calcifications and epileptic foci

Cukiert, Arthur; Puglia, Paulo; Scapolan, H.B.; Vilela, Marina Moscardini; Marino, Raul

doi:10.1590/s0004-282x1994000300001

Cited by 37 publications

(37 citation statements)

References 18 publications

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“…This prevalence of bitemporal abnorm a l i t i e s i n c reases as the duration of the EEG re c o rdings increased. Other studies have also shown that surface EEG findings consisting of bilateral independent temporal foci, did not correlate with the effect of surgery in seizure's control 26,27 .…”

Section: Discussionmentioning

confidence: 93%

Ganglioglioma: comparison with other low-grade brain tumors

Brainer-Lima

Filho

2006

Arq. Neuro-Psiquiatr.

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-Method: F o rty-two patients with low-grade brain tumor and re f r a c t o ry epilepsy were studied. The mean age was 22.3 years. They were divided into two groups: Group A, patients with ganglioglioma (n=19) and group B, patients with other low-grade tumors (n=23) (14 astrocytoma, 6 oligodend roglioma, 2 dysembryoplastic neuroepithelial tumor, and 1 xanthoastro c y t o m a ) . Results: Age at seizure 's onset was 7 years or less in 73% of the patients in group A and in 30.4% of the patients in group B (p=0.045). Complex partial occurred frequently in group A and B (94.7% versus 82%, respectively). Seizure 's fre q u e ncy was higher in group B (p=0.002).Computerized tomography (CT) was normal in 36.8% of group A patients and abnormal in all group B patients. Magnetic resonance imaging (MRI) was abnormal in all patients. S u rgical removal was complete in 89.5% of the patients in group A and in 78.2% of the patients in gro u p B . Conclusion: The association of re f r a c t o ry epilepsy and complex partial seizures, at a relatively low freq u e n c y, in young patients potentially normal CT and a MRI hypointense temporal lobe lesion in T1-weighed slices were habitual image findings in ganglioglioma, rather than other low-grade tumor.KEY WORDS: ganglioglioma, refractory epilepsy, low-grade brain tumors.Ganglioglioma: estudo comparativo com outros tumores cerebrais primarios de baixo grau RESUMO -Método: Foram estudados 42 pacientes com tumor cerebral primário de baixo grau e epilepsia refratária. A idade média foi 22,3 anos. Eles foram divididos em dois grupos: no grupo A os pacientes com ganglioglioma (n=19) e no grupo B os pacientes com outros tumores primários de crescimento lento (n=23) (14 astrocitomas, 6 oligodendrogliomas, 2 tumores desembrioblástico neuroepitelial e um xantoastro c i t om a ) . Resultados: A idade de início das crises convulsivas foi 7 anos ou menos em 73% dos pacientes no g rupo A e 30,4% dos pacientes no grupo B (p=0,045). A crise convulsiva do tipo parcial complexa foi a mais identificada nos grupos A e B (94,7% versus 82%, respectivamente). A freqüência de crise foi mais alta no g rupo B (p=0,002). A tomografia computadorizada foi normal em 36,8% dos pacientes no grupo A e anormal em todos no grupo B. A ressonância magnética foi anormal em todos os pacientes. A remoção cirúr-gica foi completa em 89.5% dos pacientes no grupo A e 78,2% no grupo B. Conclusão: A associação de epilepsia refratária e crise parcial complexa, principalmente quando a freqüência não é muito alta, em pacientes jovens, mesmo com tomografia computadorizada normal e alteração hipointensa na seqüência de T1 da ressonância magnética é sugestiva de ganglioglioma mais que outros tipos de tumor cere b r a l primário de baixo grau. PALAVRAS-CHAVE: ganglioglioma, epilepsia refratária, tumor cerebral de baixo grau.Ganglioglioma (GG) is one of the commonest causes of tumor-related re f r a c t o ryepilepsy in young pat i e n t s 1 , and together with other low-grade brain neop l a s m 's, comprises 10-30% of the ...

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Section: Discussionmentioning

confidence: 93%

Ganglioglioma: comparison with other low-grade brain tumors

Brainer-Lima

Filho

2006

Arq. Neuro-Psiquiatr.

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“…For example, patients with severe refractory seizures may have only one calcified lesion and patients with multiple cysts or calcifications may have no seizures. Electroencephalography (EEG) has been found to be abnormal in 30% to 50% of patients with seizures due to NC and thus, EEG findings may have poor correlation with symptoms and CT lesions in patients with NC 37,38 . Discrepancies between clinical localization based on seizure semiology and location of the lesion on neuroimaging is not uncommon in patients with NC.…”

Section: Epileptogenesis Of Neurocysticercosis Lesionsmentioning

confidence: 99%

The relationship between neurocysticercosis and epilepsy: an endless debate

Carpio

Romo

2014

Arq. Neuro-Psiquiatr.

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Neurocysticercosis (NC), or cerebral infection with Taenia solium, is an important public health problem worldwide. Among the neurological sequelae of NC, seizures have been described as the most common symptom. Acute symptomatic seizures often result from degeneration of a viable cyst; however, not all of these patients with acute or provoked seizures will develop epilepsy (i.e., recurrent unprovoked seizures). Because of the high prevalence of epilepsy and NC, a causal, as well as incidental relationship between the two may exist. The epileptogenicity of calcified cysts as well as the potential association between NC and hippocampal sclerosis necessitates future research. Antihelminthic treatment of NC results in disappearance of viable cysts in about one-third of patients with parenchymal disease, but a reduction in seizure recurrence has not been demonstrated in randomized controlled trials. Prevention is critical to reduce the burden of seizure and epilepsy related to NC.Keywords: cysticercosis, Taenia solium, seizure, parasitic. RESUMOA neurocisticercose (NC) ou infecção cerebral pela Taenia solium é importante problema de saúde pública em todo o mundo. Entre as sequelas neurológicas da NC, as crises convulsivas têm sido descritas como os sintomas mais frequentes. Crises convulsivas sintomáticas agudas resultam, muitas vezes, da degeneração de cistos viáveis; entretanto, nem todos os pacientes com NC e crises agudas ou provocadas desenvolvem epilepsia (i.e., crises recorrentes não provocadas). Pode haver uma relação entre epilepsia e NC, causal ou incidental, devido à alta prevalência de ambas. O potencial epileptogênico dos cistos calcificados assim como a possível associação entre NC e esclerose hipocampal ainda necessitam de futuras pesquisas. O tratamento anti-helmíntico da NC resulta no desaparecimento de cistos viáveis em cerca de 1/3 dos pacientes com a doença parenquimatosa, mas não foi demonstrada redução nas taxas de recorrência das crises convulsivas em estudos randomizados controlados. A prevenção é crítica para reduzir o contingente de crises convulsivas e epilepsia relacionadas à NC.

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“…3 Seizures commonly occur in the presence of calcified granulomas [4][5][6][7][8][9] and are frequently localized to them. [10][11][12] Moreover, recurrent, transient episodes of perilesional edema (PEC) and enhancement, both maximally centered around the calcifications, have been described. 13,14 In a recent prospective study of patients with only calcified granulomas and a history of remote seizures, PEC was found in 50% of those patients with recurrent seizures and 8.7% of asymptomatic controls from the same population.…”

Section: Introductionmentioning

confidence: 99%

A Calcified Taenia solium Granuloma Associated with Recurrent Perilesional Edema Causing Refractory Seizures: Histopathological Features

Ooi¹,

Wijemanne²,

Thomas³

et al. 2011

The American Society of Tropical Medicine and Hygiene

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We describe the first detailed histological description of an excised calcified Taenia solium granuloma from a patient who developed recurrent seizures associated with perilesional edema surrounding a calcified cysticercus (PEC). The capsule, around a degenerated cysticercus, contained marked mononuclear infiltrates that extended to adjacent brain, which showed marked astrocytosis, microgliosis, and inflammatory perivascular infiltrates. The presence of large numbers of mononuclear cells supports an inflammatory cause of PEC. Immunosuppression or anti-inflammatory measures may be able to treat and prevent PEC and recurrent seizures.

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Congruence of the topography of intracranial calcifications and epileptic foci

Cited by 37 publications

References 18 publications

Ganglioglioma: comparison with other low-grade brain tumors

Ganglioglioma: comparison with other low-grade brain tumors

The relationship between neurocysticercosis and epilepsy: an endless debate

A Calcified Taenia solium Granuloma Associated with Recurrent Perilesional Edema Causing Refractory Seizures: Histopathological Features

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