Conhecimento e Manejo Sustentável da Biodiversidade Amapaense

Bastos, Argemiro Midonês; Miranda, José Policarpo; Silva, Raullyan Borja Lima e

doi:10.5151/9788580392197

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…This enzyme is responsible for the proteolytic activity, survival, and growth of the parasite. Nitric Oxide (NO) inactivates cruzain by S-nitrosylation of the binding site, therefore, it has been proposed that Ru-nitrosylcontaining compounds could demonstrate selective and pleiotropic activity by inhibiting the action of glyceraldehyde 3-phosphate dehydrogenase [42]. Furthermore, compounds with a general formula [RuCl2(ATZ)(COD)] (COD = 1,5-cyclo-octadi-ene) have high activity against the trypomastigote form of T.…”

Section: American Trypanosomiasismentioning

confidence: 99%

“…mitochondria swelling, and nuclear membrane loss leading to necrosis of the parasitic cell. Multiple mechanisms of antiparasitic activity on differing areas of the cell could prove beneficial in reducing resistance generation.When ct-[RuCl(NO)(dpp-b)(5,5=-mebipy)](PF6)2 was used synergistically with benznidazole at 75 μmol/Kg and 38 μmol/Kg, 100% survival rate and lower parasitaemia was observed than with the individual treatments[42].The compound trans-[Ru(Bz)(NH3)4-SO2](CF3SO3)2 has been shown to exhibit antiparasitic effects at lowconcentrations. It is also capable of catalysing nitrite to nitrosyl conversion at a low concentration of 0.4 μmol/kg and decreasing the number of parasites in the heart.…”

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confidence: 99%

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Ruthenium Metallotherapeutics: Novel Approaches to Combatting Parasitic Infections

Britten

Butler

2022

CMC

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Human parasitic infections cause a combined global mortality rate of over one million people per annum and represent some of the most challenging diseases for medical intervention. Current chemotherapeutic strategies often require prolonged treatment, coupled with subsequent drug-induced cytotoxic morbidity to the host, while resistance generation is also a major concern. Metals have been used extensively throughout the history of medicine, with more recent applications as anticancer and antimicrobial agents. Ruthenium metallotherapeutic antiparasitic agents are highly effective at targeting a range of key parasites, including the causative agents of malaria, trypanosomiasis, leishmaniasis, amoebiasis, toxoplasmosis and other orphan diseases, while demonstrating lower cytotoxicity profiles than current treatment strategies. Generally, such compounds also demonstrate activity against multiple cellular target sites within parasites, including inhibition of enzyme function, cell membrane perturbation, and alterations to metabolic pathways, therefore reducing the opportunity for resistance generation. This review provides a comprehensive and subjective analysis of the rapidly developing area of ruthenium metal-based antiparasitic chemotherapeutics, in the context of rational drug design and potential clinical approaches to combatting human parasitic infections.

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Section: American Trypanosomiasismentioning

confidence: 99%

mentioning

confidence: 99%

Ruthenium Metallotherapeutics: Novel Approaches to Combatting Parasitic Infections

Britten

Butler

2022

CMC

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Evaluation of the SWAT Model for the Simulation of Flow and Water Balance Based on Orbital Data in a Poorly Monitored Basin in the Brazilian Amazon

et al. 2022

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The Amazon basin, the world’s largest river basin, is a key global climate regulator. Due to the lack of an extensive network of gauging stations, this basin remains poorly monitored, hindering the management of its water resources. Due to the vast extension of the Amazon basin, hydrological modeling is the only viable approach to monitor its current status. Here, we used the Soil and Water Assessment Tool (SWAT), a process-based and time-continuous eco-hydrological model, to simulate streamflow and hydrologic water balance in an Amazonian watershed where only a few gauging stations (the Jari River Basin) are available. SWAT inputs consisted of reanalysis data based on orbital remote sensing. The calibration and validation of the SWAT model indicated a good agreement according to Nash-Sutcliffe (NS, 0.85 and 0.89), Standard Deviation Ratio (RSR, 0.39 and 0.33), and Percent Bias (PBIAS, −9.5 and −0.6) values. Overall, the model satisfactorily simulated water flow and balance characteristics, such as evapotranspiration, surface runoff, and groundwater. The SWAT model is suitable for tropical river basin management and scenario simulations of environmental changes.

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Conhecimento e Manejo Sustentável da Biodiversidade Amapaense

Cited by 2 publications

References 23 publications

Ruthenium Metallotherapeutics: Novel Approaches to Combatting Parasitic Infections

Ruthenium Metallotherapeutics: Novel Approaches to Combatting Parasitic Infections

Evaluation of the SWAT Model for the Simulation of Flow and Water Balance Based on Orbital Data in a Poorly Monitored Basin in the Brazilian Amazon

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