Conjoined twins after intracytoplasmic sperm injection and transfer of day-3 embryos

Mercan, Ramazan; Öktem, Özgür; Salar, Zeki; Nuhoglu, Alp; Balaban, Başak; Urman, Bülent

doi:10.1016/j.fertnstert.2011.06.002

Cited by 16 publications

(13 citation statements)

References 36 publications

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“…Case reports describing extremely rare complications of twinning are reported regularly following assisted reproduction treatment and in particular after ICSI. The two most reported conditions are conjoined twins (Hirata et al, 2009;Mercan et al, 2011;Poret et al, 2010; Figure 2) and twin pregnancies combining a complete hydatidiform mole and a normal gestational sac (Kwon et al, 2002;Shazly et al, 2012;Vandenhove et al, 2008). The former condition has an incidence of 1 per 50,000 pregnancies and the later of 1 per 22,000-100,000 pregnancies (Pajkrt and Jauniaux, 2005;Wee and Jauniaux, 2005).…”

Section: Rare Anomaliesmentioning

confidence: 99%

Do assisted-reproduction twin pregnancies require additional antenatal care?

Jauniaux

Ben‐Ami

Maymon

2013

Reproductive BioMedicine Online

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Iatrogenic twinning has become the main side-effect assisted reproduction treatment. We have evaluated the evidence for additional care that assisted-reproduction twins may require compared with spontaneous twins. Misacarriages are increased in women with tubal problems and after specific treatments. Assisted-reproduction twin pregnancies complicated by a vanishing twin after 8 weeks have an increased risk of preterm delivery and of low and very low birthweight compared with singleton assisted-reproduction pregnancies. Monozygotic twin pregnancies occur at a higher rate after assisted reproduction treatment and are associated with a higher risk of perinatal complications. The incidence of placenta praevia and vasa praevia is increased in assisted-reproduction twin pregnancies. Large cohort studies do not indicate a higher rate of fetal congenital malformations in assisted-reproduction twins. Overall, assisted-reproduction twins in healthy women <45 years of age are not associated with a notable increase in antenatal complication rates and thus do not require additional antenatal care compared with spontaneous twins. The risks of maternal and fetal morbidity and mortality associated with assisted-reproduction twins is only increased in women with a pre-existing medical condition such as hypertensive disorders and diabetes and most of these risks can be avoided with single-embryo transfer. Following the birth of the first IVF baby, rumours started to spread in both the medical literature and the media about the long-term health effects for children born following assisted reproduction treatment. However, after more than 30 years, the most common complications associated with IVF treatment remain indirect and technical such as the failure of treatment and ovarian hyperstimulation. Iatrogenic twinning has become the main side-effect of assisted reproduction treatment and the increasing number of twin pregnancies, in particular in older women, has generated numerous debates on the need for additional healthcare provision. In this review, we have evaluated the evidence for additional care that assisted-conception twin pregnancies may require compared with spontaneous twin pregnancies. Twin pregnancies are obviously at higher risk of perinatal complications than singletons due to a natural increase in the incidence of fetal anomalies, antenatal disorders and obstetric and neonatal complications associated with the development of two fetuses instead of one. Overall, our review indicates that some antenatal complications are more frequent in assisted-conception twin pregnancies than in spontaneous twin pregnancies but their prevalence is low and thus their impact on the morbidity and mortality of an individual assisted-conception twin pregnancy is limited. Assisted reproduction treatment has become available to older women with pre-existing maternal medical conditions such as chronic hypertension and diabetes. The increased obstetrical risks in this population must be considered prior to attempts at assisted conception, a...

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Section: Rare Anomaliesmentioning

confidence: 99%

Do assisted-reproduction twin pregnancies require additional antenatal care?

Jauniaux

Ben‐Ami

Maymon

2013

Reproductive BioMedicine Online

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“…The emergence of several cases of conjoined twins when assisted reproduction procedures were used (intracytoplasmic sperm injection), and epidemiological studies that found no association with genetic factors (Mercan et al., ; Mutchinick et al., ) strengthen the hypothesis that the cause of cephalothoracopagus is environmental, irrespective of the mechanism involved (fission or fusion). However, with regard to normal monozygotic twins, in some families, there is a clear recurrence with a suggestive pattern of dominant autosomal inheritance (Harvey, Huntley, & Smith, ; Machin, ).…”

Section: Discussionmentioning

confidence: 96%

Canine conjoined twinning: A pathoanatomical study of a Lhasa Apso symmetrical cephalothoracopagus

Moura

Thon

Pimpão

2017

Anat Histol Embryol

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A female pair of conjoined twins of the Lhasa Apso canine breed was subjected to tomographic and anatomical examinations. The twins had only one head and neck. The two ribcages were joined, extending to the umbilicus, with duplicated structures thereafter. They had three thoracic limbs and two pelvic girdles with four limbs, as well as a number of abnormalities in their internal organs. The data obtained were compared with the rare canine cases reported so far and with human cases.

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“…In literature, sixteen cases [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] of conjoined twins after ART have been reported to date ( Table 1). Description of embryos transferred is included in only five case reports: thoracopagus twins are reported after a transfer of a 4-cell embryo with even-sized blastomeres and <10% fragmentation on day 2 [7], a transfer of three good quality 8-cell embryos on day 3 [8], a transfer of two blastocysts (early and 4BB) on day 5 [9] and 6-and 7-cell embryos on day 3 [10]. Cephalopagus CT was reported after a sequential transfer of 4-cell embryo on day 3 and an extended blastocyst on day 5 [11].…”

Section: Discussionmentioning

confidence: 99%