Conjoined twins in West Africa.

Mabogunje, O A; Lawrie, J. H.

doi:10.1136/adc.55.8.626

Cited by 25 publications

(10 citation statements)

References 18 publications

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“…Although several references to clusters of CT have been observed [Hanson, 1975; Källén and Rybo, 1978; Mabogunje and Lawrie, 1980; Viljoen et al, 1983; Zake, 1984; Rees et al, 1993; Savona‐Ventura et al, 2009] a clear explanation has not been found. Different explanations bias in the results have been considered, particularly with respect to population types and sizes surveyed, and hospital records not contributing to the regional or national SPs or a multicentric hospital‐based surveillance system.…”

Section: Discussionmentioning

confidence: 99%

Conjoined twins: A worldwide collaborative epidemiological study of the International Clearinghouse for Birth Defects Surveillance and Research

Mutchinick

Luna‐Muñoz

Amar³

et al. 2011

American J of Med Genetics Pt C

172

161

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Conjoined twins (CT) are a very rare developmental accident of uncertain etiology. Prevalence has been previously estimated to be 1 in 50,000 to 1 in 100,000 births. The process by which monozygotic twins do not fully separate but form CT is not well understood. The purpose of the present study was to analyze diverse epidemiological aspects of CT, including the different variables listed in the Introduction Section of this issue of the Journal. The study was made possible using the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR) structure. This multicenter worldwide research includes the largest sample of CT ever studied. A total of 383 carefully reviewed sets of CT obtained from 26,138,837 births reported by 21 Clearinghouse Surveillance Programs (SP) were included in the analysis. Total prevalence was 1.47 per 100,000 births (95% CI: 1.32-1.62). Salient findings including an evident variation in prevalence among SPs: a marked variation in the type of pregnancy outcome, a similarity in the proportion of CT types among programs: a significant female predominance in CT: particularly of the thoracopagus type and a significant male predominance in parapagus and parasitic types: significant differences in prevalence by ethnicity and an apparent increasing prevalence trend in South American countries. No genetic, environmental or demographic significant associated factors were identified. Further work in epidemiology and molecular research is necessary to understand the etiology and pathogenesis involved in the development of this fascinating phenomenon of nature.

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Section: Discussionmentioning

confidence: 99%

Conjoined twins: A worldwide collaborative epidemiological study of the International Clearinghouse for Birth Defects Surveillance and Research

Mutchinick

Luna‐Muñoz

Amar³

et al. 2011

American J of Med Genetics Pt C

172

161

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“…The stillbirth rate in Nigeria is not known, but available data suggest a higher than national average stillbirth rate among mothers of conjoined twins. 12 Spencer reported a high stillbirth rate in his series and suggested that a maternal factor might be of aetiological importance in conjoined twinning. 15 This case was not detected antenatally, and the diagnosis was made only at emergency operative delivery.…”

Section: Discussionmentioning

confidence: 97%

“…To the best of our knowledge, 12 cases have been reported from Nigeria during the last 60 years. [4][5][6][7][8][9][10][11][12][13][14] This probably does not re ect the true incidence in Nigeria as most cases are not reported on account of the associated stigma. Cases of conjoined twins seen in hospital are rare and pose a management challenge when they do present because of a lack of experience in managing them.…”

Section: Introductionmentioning

confidence: 99%

The Ibadan conjoined twins: a report of omphalopagus twins and a review of cases reported in Nigeria over 60 years

Omokhodion

Ladipo

Odebode

et al. 2001

Annals of Tropical Paediatrics

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An omphalopagus set of female conjoined twins, undiagnosed prenatally, who presented as obstructed labour needing operative delivery is reported. Their anatomic characteristics and clinical features, including overwhelming sepsis in twin II which forced early separation, and those which led to their demise are described. Twelve other cases reported in Nigeria over the past 60 years are reviewed with reference to the aetiology and epidemiology of conjoined twinning and the determinants of successful surgical separation.

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“…7 In contrast, the fusion theory proposes that two mono ovular empirical discs lie adjacent to one another at various angles and become secondly united dorsally, caudally, laterally or dorsally and symmetrically or asymmetrically but always homologous. 8 A study done by Mutchinick et al demonstrated that the incidence of conjoined twinning was 1.47 per 100,000 births. There has been a marked variation in the surveillance programs and has shown that highest prevalence was found to be in Finland with 3.22 per 100,000 births and it has been as low as 0.08 per 100,000 births in Italy.…”

Section: Discussionmentioning

confidence: 99%

A rare case of conjoined twins presenting as dicephalus parapagus: a case report

Subburaj

Rajkumar

2019

Int J Reprod Contracept Obstet Gynecol

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Conjoined twinning is a congenital abnormality resulting in various presentations of the fetuses in utero. It is a rare embryological developmental disorder occurring in one in 100,000 births. We present a case of conjoined twinning, which is characterized by the presence of two heads, single vertebral column and single symphysis pubis, with single genitor-urinary tract and single gastro intestinal tract. The present condition, referred to as dicephalus parapagus, is a rare entity among the conjoined twinning and has seldom positive outcomes. The mechanism of occurrence of conjoined twinning has been proposed either through fusion or fission of the embryos. In either case, surgical separation of the conjoined twins is often unsuccessful and results in increased morbidity and mortality. However, it is essential to screen for the presence of such congenital anomalies early during pregnancy, in order to terminate and provide parental counselling.

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Conjoined twins in West Africa.

Cited by 25 publications

References 18 publications

Conjoined twins: A worldwide collaborative epidemiological study of the International Clearinghouse for Birth Defects Surveillance and Research

Conjoined twins: A worldwide collaborative epidemiological study of the International Clearinghouse for Birth Defects Surveillance and Research

The Ibadan conjoined twins: a report of omphalopagus twins and a review of cases reported in Nigeria over 60 years

A rare case of conjoined twins presenting as dicephalus parapagus: a case report

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