This paper presents a computational method to investigate cooling performance of NASA-C3X cascade vane coated with thermal barrier coating (TBC), for which experimental data are available. The vane was cooled internally by air flows through radially oriented 10 channels. A three-dimensional conjugate heat transfer simulation has been performed which allows the conduction-convection on metal vane by eliminating need of multiple boundary solutions. The predicted aerodynamic and thermal loads with the effect of turbulent intensity is found to be good agreement with experimental data and inclusion of TBC leads to quantitative reduction in vane metal temperature.