1996
DOI: 10.1093/infdis/174.6.1360
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Conjugate Meningococcal Serogroup A and C Vaccine: Reactogenicity and Immunogenicity in United Kingdom Infants

Abstract: The reactogenicity and immunogenicity of a serogroup A and C meningococcal polysaccharide-CRM197 conjugate vaccine was evaluated in 58 infants who received three doses at 2, 3, and 4 months of age. The conjugate vaccine produced few systemic side effects, and local reactions were significantly less common than those produced by the routine vaccinations. The prevaccination geometric mean titers (GMTs) of A and C polysaccharide antibodies were, respectively, 2.8 and 0.6 microg/mL, rising to 21.5 and 38.5 microg/… Show more

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Cited by 147 publications
(80 citation statements)
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“…There are studies of other meningococcal conjugate vaccines that demonstrate solid immunogenicity in infants, immunologic memory, and the booster phenomenon (37,66,97,204,219,220,234,235,(285)(286)(287)(288)(289)356). An exception to this was that one of the earliest serogroup A conjugate vaccines, a bilvalent A/C product, failed to induce immunologic memory, while the C component did, suggesting a failure to elicit a T-cell-dependent response to the group A component of the conjugate vaccine (204,356).…”
Section: Meningococcal Conjugate Vaccines In the United Statesmentioning
confidence: 99%
“…There are studies of other meningococcal conjugate vaccines that demonstrate solid immunogenicity in infants, immunologic memory, and the booster phenomenon (37,66,97,204,219,220,234,235,(285)(286)(287)(288)(289)356). An exception to this was that one of the earliest serogroup A conjugate vaccines, a bilvalent A/C product, failed to induce immunologic memory, while the C component did, suggesting a failure to elicit a T-cell-dependent response to the group A component of the conjugate vaccine (204,356).…”
Section: Meningococcal Conjugate Vaccines In the United Statesmentioning
confidence: 99%
“…Following promising results in infants vaccinated under the UK 2/3/4 month schedule [11][12][13], the DH initiated further clinical trials to answer key policy-related questions. These trials determined the schedule to be used for catch-up immunisation of older age groups [14], the effect of prior vaccination with plain meningococcal C polysaccharide used for outbreak control on the response to MCC vaccines [15][16][17], and the compatibility of MCC vaccines when given at the same time as other vaccines used in the UK schedule, in particular diphtheria and tetanus vaccines which are similar to the carrier proteins in the MCC vaccines [1].…”
Section: Pre-licensure Studiesmentioning
confidence: 99%
“…The MCC vaccines were shown to be safe and immunogenic in infants following the 2/3/4 month schedule [11][12][13]18] and in adolescents [19]. The hyporesponsiveness reported following meningococcal polysaccharide vaccines in young children and adults is overcome by administration of the MCC vaccine [15,17,20].…”
Section: Pre-licensure Studiesmentioning
confidence: 99%
“…Meningococcal serogroup C plain polysaccharide vaccines are not immunogenic in those under the age of 2 years (13,17), and repeated doses can lead to hyporesponsiveness (2,13,18,29). MCC vaccines that have been shown to be highly immunogenic and to generate immune memory in all age groups from infants to adults are now available (10,(25)(26)(27)(28)(29). MCC vaccines have been shown to be efficacious in all the age groups targeted during the vaccination campaign initiated in 1999 in the United Kingdom and elicit herd immunity (23).…”
mentioning
confidence: 99%