Conjugated Linoleic Acid Deteriorates Insulin Resistance in Obese/Diabetic Mice in Association with Decreased Production of Adiponectin and Leptin

Ohashi, Atsuko; Matsushita, Yukiko; Shibata, Haruki; Kimura, Kazuhiro; Miyashita, Kazuo; Saito, Masayuki

doi:10.3177/jnsv.50.416

Cited by 41 publications

(34 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the presence of leptin, which also decreases resistin (30), and with improved insulin sensitivity, CLA still reduced WAT expression of resistin. These data support previous reports that CLA decreases resistin levels (16,18,31) and also support a disconnect between resistin levels and insulin resistance. These data also suggest that leptin status does not influence the effect of CLA on WAT resistin expression.…”

Section: Discussionsupporting

confidence: 82%

“…The leptin dose was based on the lowest dose that induced a reduction in body weight gain and fat and rescued serum insulin levels in ob/ob mice (17). Four weeks was chosen as the end point because this duration allows time for the development of insulin resistance and hepatic steatosis induced by CLA supplementation in mice (11,12,18) and, independently, the correction of metabolic abnormalities of ob/ob mice by leptin (17,19). Body weights were measured every other day.…”

Section: Experimental Animals and Designmentioning

confidence: 99%

See 1 more Smart Citation

Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice

Wendel

Purushotham

Liu

et al. 2008

Journal of Lipid Research

View full text Add to dashboard Cite

Conjugated linoleic acid (CLA) induces insulin resistance preceded by rapid depletion of the adipokines leptin and adiponectin, increased inflammation, and hepatic steatosis in mice. To determine the role of leptin in CLAmediated insulin resistance and hepatic steatosis, recombinant leptin was coadministered with dietary CLA in ob/ob mice to control leptin levels and to, in effect, negate the leptin depletion effect of CLA. In a 2 3 2 factorial design, 6 week old male ob/ob mice were fed either a control diet or a diet supplemented with CLA and received daily intraperitoneal injections of either leptin or vehicle for 4 weeks. In the absence of leptin, CLA significantly depleted adiponectin and induced insulin resistance, but it did not increase hepatic triglyceride concentrations or adipose inflammation, marked by interleukin-6 and tumor necrosis factor-a mRNA expression. Insulin resistance, however, was accompanied by increased macrophage infiltration (F4/80 mRNA) in adipose tissue. In the presence of leptin, CLA depleted adiponectin but did not induce insulin resistance or macrophage infiltration. Despite this, CLA induced hepatic steatosis. In summary, CLA worsened insulin resistance without evidence of inflammation or hepatic steatosis in mice after 4 weeks. In the presence of leptin, CLA failed to worsen insulin resistance but induced hepatic steatosis in ob/ob mice.-Wendel, A. A., A. Purushotham, L-F. Liu, and M. A. Belury. Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J. Lipid Res. 2008. 49: 98-106.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Experimental Animals and Designmentioning

confidence: 99%

Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice

Wendel

Purushotham

Liu

et al. 2008

Journal of Lipid Research

View full text Add to dashboard Cite

show abstract

“…These cytokines induce the expression of the proteins SOCS-3 and JNK, on their part inhibiting the insulin signal transduction, which finally promotes hyperinsulinemia and insulin resistance [8] . The pro-diabetic state is additionally worsened by down-regulation of adiponectin and leptin expression in the adipose tissue; both are key mediators in insulin sensitivity [8,23,24] . Concomitantly, chemotaxis-driven influx of macrophages into the adipose tissue triggers apoptosis of adipocytes [8,9] .…”

Section: Discussionmentioning

confidence: 99%

Trans-10,cis-12-CLA-Caused Lipodystrophy Is Associated with Profound Changes of Fatty Acid Profiles of Liver, White Adipose Tissue and Erythrocytes in Mice: Possible Link to Tissue-Specific Alterations of Fatty Acid Desaturation

Jaudszus

Moeckel²,

Hamelmann³

et al. 2010

Ann Nutr Metab

View full text Add to dashboard Cite

Dietary supplementation with conjugated linoleic acid (CLA) has been shown to reduce body fat mass. To investigate the effects of individual CLA isomers on the fatty acid profiles of lipogenic (liver and white adipose) and lipid sensitive (erythrocyte) tissues, BALB/c mice were fed with 1 of 2 diets supplemented with either a c9,t11-CLA-enriched and t10,c12-CLA-free or a CLA-mixture containing both isomers in equal amounts (1% w/w of the diet) for 5 weeks. A control group was fed with a diet enriched in sunflower oil to energy balance the CLA. Compared to the t10,c12-CLA-free and the control diets, we observed a significant reduction of adipose tissue accompanied by fatty livers in the CLA-mix-fed group. These alterations in body fat distribution entailed a conspicuous shift of the fatty acid profiles of adipose tissue and livers. Liver enlargement was mainly caused by accumulation of C18 monoenes that accounted for 67 ± 1% of total fatty acid methyl esters. The significant reduction of the 18:0/18:1 desaturation index in the liver upon CLA-mix diet indicated high stearoyl-CoA desaturase activity. In contrast, reduction in white adipose tissue was largely driven by percental reduction of monounsaturated fatty acids (p ≤ 0.001). 16:0/ 16:1 and 18:0/18:1 desaturation indices for white adipose tissue significantly increased, suggesting an inhibition of stearoyl-CoA desaturase upon CLA-mix diet. The fatty acid profile of the erythrocytes widely reflected that of livers, depending on the supplemented diet. These profound changes in fatty acid composition of lipogenic organs due to t10,c12-CLA intake may be the consequence of function- al alterations of lipid metabolism.

show abstract

“…Lo cual podría explicar el mecanismo mediante el cual la suplementación de O3 pudiera afectar sobre la masa grasa de los individuos. Adicionalmente, la suplementación de O3 ha evidenciado efectos en el sistema nervioso simpático, leptina y adiponectina, hormonas que están encargados de la regulación de masa grasa, disminución de la sensación de hambre y aumento de la saciedad posprandial (30). Por otro lado, Totland y cols.…”

Section: Efectos De La Suplementación De Omega-3 Y Entrenamiento De Iunclassified

Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso

et al. 2016

View full text Add to dashboard Cite

Zbinden-Foncea H. Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso. Nutr Hosp 2016;33:848-855 DOI: http://dx.doi.org/10.20960/nh.380Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso Effects of omega-3 supplementation and high intensity interval training in physical performance, blood pressure and body composition in overweight individuals AbstractBackground: High Intensity Interval Training (HIIT) has shown to increase oxidative capacity and maximum oxygen consumption (VO 2max ) in different populations. On the other side, the consumption of Omega-3 fatty acids (O3) has positive effects on oxidative metabolism. Objective: To observe the effects of a combination of HIIT and O3 supplementation on parameters of physical performance, blood pressure, and body composition in overweight adults. Methods: 28 young, non-active, overweight individuals (22 ± 4 years; BMI = 25.8 ± 2.4 kg/m

show abstract

Conjugated Linoleic Acid Deteriorates Insulin Resistance in Obese/Diabetic Mice in Association with Decreased Production of Adiponectin and Leptin

Cited by 41 publications

References 31 publications

Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice

Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice

Trans-10,cis-12-CLA-Caused Lipodystrophy Is Associated with Profound Changes of Fatty Acid Profiles of Liver, White Adipose Tissue and Erythrocytes in Mice: Possible Link to Tissue-Specific Alterations of Fatty Acid Desaturation

Efectos de la suplementación de omega-3 y entrenamiento de intervalos de alta intensidad en el rendimiento físico, presión arterial y composición corporal en individuos sedentarios con sobrepeso

Contact Info

Product

Resources

About