Conjugated linoleic acid does not affect digestion and absorption of fat and starch—a randomized, double-blinded, placebo-controlled parallel study

Abstract

Supplementation with CLA for 3 months did not affect fat and starch digestion assessed by C mixed triglyceride breath test andC starch breath test.

Conjugated linoleic acid (CLA) reduces intestinal fatty acid uptake and chylomicron formation in HFD-fed mice associated with the inhibition of DHHC7-mediated CD36 palmitoylation and the downstream ERK pathway

“…43 Differently from our results, CLA didn't affect the fat digestion and absorption in humans. 44 This may be due to the different regulatory effects of CLA on fat absorption in different species. Moreover, the lipoprotein lipase (LPL) inhibitor poloxamer 407 injection and lard oil gavage experiments were conducted to directly evaluate the intestinal fat absorption of mice (Fig.…”

Psychological determinants of the effectiveness of conjugated linoleic acid supplementation in overweight and obese women—a randomized controlled trial

“…The main outcomes of the study included an assessment of psychological behaviors that could determine the effectiveness of the study intervention. However, this manuscript is part of a larger project which aimed to evaluate the effect of CLA supplementation on starch and lipid digestion using a breath test ( 29 ) and the secondary purpose of the project was to assess the effect of CLA supplementation on anthropometric parameters ( 25 ), body composition and liver markers ( 26 ), atherosclerosis parameters ( 28 ), densitometric variables ( 30 ), glucose and insulin homeostasis, lipid metabolism and adipokine levels, as reported previously. All outcomes were assessed at the Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poland.…”

The Effect of Conjugated Linoleic Acid Supplementation on Densitometric Parameters in Overweight and Obese Women—A Randomised Controlled Trial

“…As described previously [ 9 , 24 , 25 , 26 , 27 ], the study was designed as a parallel, double-blind, randomised controlled trial, registered with the German Clinical Trials Register database (ID: DRKS00010462, date of registration: 4 May 2016) [ 28 ]. The study protocol was approved by the Poznan University of Medical Sciences Ethics Committee (protocol code: 606/12, date of approval: 14 June 2012; protocol code: 453/13, date of approval: 9 May 2013; protocol code: 358/14, date of approval: 3 April 2014; protocol code: 398/15, date of approval: 9 April 2015).…”

“…The primary outcome of the study was the effect of CLA supplementation on the digestion of starch and lipids [ 27 ]. Here, we reported the effects of CLA intervention on secondary outcomes, which included the impact on densitometric parameters.…”