Conjugated microporous polymers as a novel generation of drug carriers: A systemic study toward efficient carriers of tetracycline antibiotic

Mousa, Aya Osama; Mohamed, Mohamed Gamal; Lin, Zheng‐Ian; Chuang, Cheng-Hsin; Chen, Chih‐Kuang; Kuo, Shiao‐Wei

doi:10.1016/j.eurpolymj.2023.112254

Cited by 17 publications

(7 citation statements)

References 59 publications

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“…Palladium tetrakis(triphenylphosphine) [Pd(PPh 3 ) 4 ], 4-bromoaniline (97%), 3-bromoaniline (98%), pyridine (99.8%), CuBr (98%), potassium carbonate (K 2 CO 3 , 99.9%), methanol (MeOH), bromine (Br 2 ), chloroform (CHCl 3 ), acetone (CH 3 COCH 3 ), triphenylphosphine (PPh 3 , 99%), pyrene (Py, 98%), tetrahydrofuran (THF), anhydrous magnesium sulfate (MgSO 4 , 99.5%), copper(I) iodide (CuI, 99%), and other solvents were purchased commercially from Sigma-Aldrich. 1,3,6,8-Tetrakis(2-(trimethylsilyl)ethynyl) pyrene (Py-TMS) was prepared following established protocols. − …”

Section: Methodsmentioning

confidence: 99%

Systematic Design and Synthesis of Conjugated Microporous Polymers Containing Pyrene and Azobenzene Building Materials for High-Performance Energy Storage

Singh,

Mohamed,

Kuo

2023

ACS Appl. Energy Mater.

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Conjugated microporous polymers (CMPs), known for their high specific capacities, exceptional cycling stability, and outstanding rate performance, are being actively studied as advanced electrode materials for energy storage applications. The utilization of redox-active units in CMP materials in energy storage exhibits substantial promise. Nevertheless, the influence of the positioning of the redox-active region on the electrochemical behavior and battery performance remains a topic of uncertainty. Herein, we successfully created two CMPs using the Sonogashira− Hagihara coupling method, specifically by including redox-active azobenzene (Azo) moieties in the meta (m) and para (p) locations. These CMPs are named Py-mAzo-CMP and Py-pAzo-CMP. To produce them, we used precursor compounds (E)-1,2-bis(3bromophenyl)diazene (mAzo-Br 2 ) and (E)-1,2-bis(4-bromophenyl)diazene (pAzo-Br 2 ), combined with tetraethynylpyrene (Py-T). Our primary focus was to investigate the impact of substituting the Azo unit at different positions. To assess the orientation of molecules and the pores of these Py-Azo-CMPs, we conducted a thorough analysis, including BET isotherm measurements and various spectroscopic and microscopic techniques. Our findings from TGA analysis indicated that these Py-Azo-CMPs exhibit a moderate thermal stability. One remarkable discovery was the excellent electrochemical performance of Py-pAzo-CMP, which displayed a capacitance of 142 F g −1 (determined at 1 A g −1 ), showcasing its exceptional capacitive properties. Despite operating at a substantial current density of 10 A g −1 , both Py-mAzo and Py-pAzo-CMPs exhibited remarkable long-term stability, retaining over 92% of their capacity even after 5000 cycles. These results underscore the potential of Py-pAzo-CMP as a dependable and enduring choice for energy storage applications. Our findings highlight the significant promise of these Py-Azo-CMP materials and underscore their suitability for useful applications, including electrical energy storage (EES).

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Section: Methodsmentioning

confidence: 99%

Systematic Design and Synthesis of Conjugated Microporous Polymers Containing Pyrene and Azobenzene Building Materials for High-Performance Energy Storage

Singh,

Mohamed,

Kuo

2023

ACS Appl. Energy Mater.

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“…[47][48][49][50][51][52][53][54][55][56][57][58][59][60] CMPs could be synthesized using various methods such as Schiff base condensation, Suzuki-Miyaura, Sonogashira, Heck coupling processes, mechanochemical synthesis, solvothermal or hydrothermal methods, microwaveassisted synthesis, and more, all of which are both economically viable and user-friendly. 54,57,[61][62][63][64][65][66][67][68][69] Various monomers featuring diverse functional groups, including aldehydes, amines, and halides, can be employed in the synthesis of CMPs. Notably, CMPs exhibit exceptional chemical and physical stability.…”

Section: Introductionmentioning

confidence: 99%

Reticular design and alkyne bridge engineering in donor–π–acceptor type conjugated microporous polymers for boosting photocatalytic hydrogen evolution

Mohamed,

Elsayed,

et al. 2024

J. Mater. Chem. A

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“…These applications span gas storage and separation, photo-catalysis, bioimaging, antibacterial treatments, biosensing, optoelectronic devices, dye adsorption, and drug delivery, showcasing the multifaceted capabilities of CMP frameworks. 46–51 Previous studies have underscored the efficacy of utilizing CMPs in both antibacterial applications and supercapacitors. Wang et al devised a method to enhance the antibacterial properties of CMPs by introducing hydantoin groups, resulting in superior performance.…”

Section: Introductionmentioning

confidence: 99%

Bifunctional imidazolium linked tetraphenylethene based conjugated microporous polymers for dynamic antibacterial properties and supercapacitor electrodes

Mousa,

Lin,

Chaganti

et al. 2024

Polym. Chem.

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Conjugated microporous polymers as a novel generation of drug carriers: A systemic study toward efficient carriers of tetracycline antibiotic

Cited by 17 publications

References 59 publications

Systematic Design and Synthesis of Conjugated Microporous Polymers Containing Pyrene and Azobenzene Building Materials for High-Performance Energy Storage

Systematic Design and Synthesis of Conjugated Microporous Polymers Containing Pyrene and Azobenzene Building Materials for High-Performance Energy Storage

Reticular design and alkyne bridge engineering in donor–π–acceptor type conjugated microporous polymers for boosting photocatalytic hydrogen evolution

Bifunctional imidazolium linked tetraphenylethene based conjugated microporous polymers for dynamic antibacterial properties and supercapacitor electrodes

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