This paper reviews the impacts of employing inserts, nanofluids, and their combinations on the thermal performance of flat plate solar collectors. The present work outlines the new studies on this specific kind of solar collector. In particular, the influential factors upon operation of flat plate solar collectors with nanofluids are investigated. These include the type of nanoparticle, kind of base fluid, volume fraction of nanoparticles, and thermal efficiency. According to the reports, most of the employed nanofluids in the flat plate solar collectors include Al2O3, CuO, and TiO2. Moreover, 62.34%, 16.88%, and 11.26% of the utilized nanofluids have volume fractions between 0 and 0.5%, 0.5 and 1%, and 1 and 2%, respectively. The twisted tape is the most widely employed of various inserts, with a share of about one-third. Furthermore, the highest achieved flat plate solar collectors’ thermal efficiency with turbulator is about 86.5%. The review is closed with a discussion about the recent analyses on the simultaneous use of nanofluids and various inserts in flat plate solar collectors. According to the review of works containing nanofluid and turbulator, it has been determined that the maximum efficiency of about 84.85% can be obtained from a flat plate solar collector. It has also been observed that very few works have been done on the combination of two methods of employing nanofluid and turbulator in the flat plate solar collector, and more detailed work can still be done, using more diverse nanofluids (both single and hybrid types) and turbulators with more efficient geometries.