Conjugated nonadecadienoic acid is more potent than conjugated linoleic acid on body fat reduction

Park, Yooheon; Park, Yeonhwa

doi:10.1016/j.jnutbio.2009.05.003

Cited by 20 publications

(19 citation statements)

References 61 publications

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“…Of particular importance CLA‐fed mice were shown to activate AMPKα and upregulate mitochondria‐related molecular markers, such as PPARδ and Tfam in both wild type and N2KO mice, potentially via PGC‐1α. These observations further support that CLA supplementation may help improve physical activity, and change body composition including increased lean body mass in previous animal studies . This is the first report that CLA treatment may lead to preventing the development of obesity in adult‐onset inactivity induced obese mice by stimulating mitochondrial biogenesis.…”

Section: Discussionsupporting

confidence: 87%

Conjugated linoleic acid (CLA) influences muscle metabolism via stimulating mitochondrial biogenesis signaling in adult‐onset inactivity induced obese mice

Kim

Good

et al. 2015

Euro J Lipid Sci & Tech

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Recently, conjugated linoleic acid (CLA) has been reported to prevent body weight gain and fat accumulation in part by improving physical activity in mice. The current study was conducted to determine the role of CLA on skeletal muscle metabolism in nescient basic helix-loop-helix 2 knockout (N2KO) mice, an adult-onset inactivity induced obese model. Five-week-old female N2KO and wild type mice were fed either control or CLA containing diet (0.5%) for 10 wk. Voluntary activity was determined biweekly and markers for muscle metabolisms were determined from the gastrocnemius muscle. CLA fed N2KO animals showed significant increased voluntary movement and gastrocnemius muscle mass compared to control group, whereas in wild type animals, no differences were observed. CLA treatment up-regulated AMP-activated protein kinase (AMPK), mitochondria biogenic markers, peroxisome proliferator-activated receptor-d (PPARd), and mitochondrial transcription factor A (Tfam) compared to control animals. These observations indicate that CLA supplementation activates AMPKa-PPARd and/or -Tfam signaling cascade for stimulating mitochondria biogenesis. Taken together, these results suggest that CLA may in part activate the underlying biomarkers involved in muscle metabolism via stimulation of mitochondrial biogenesis, resulting in increased voluntary activity and muscle mass, potentially contributing to regulating weight gain.Practical applications: Lack of physical activity is a global public health problem, which induces obesity and its associated pathologies. Approximately, 3.2 million deaths per year are attributable to lack of physical activity. CLA has previously been reported to increase voluntary and endurance activities in mice. However, the exact mode of action is not completely understood. Thus, the purpose of the study was to shed light on positive effects of CLA on physical activity through modulation of molecular targets in skeletal muscle of Nhlh2 knockout mice, which are an adult-onset inactivity induced obesity model. The current results suggest that CLA acts as a potential exercise-mimetic, resulting in increased voluntary activity and muscle mass, potentially contributing to regulating weight gain.

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Section: Discussionsupporting

confidence: 87%

Conjugated linoleic acid (CLA) influences muscle metabolism via stimulating mitochondrial biogenesis signaling in adult‐onset inactivity induced obese mice

Kim

Good

et al. 2015

Euro J Lipid Sci & Tech

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“…In addition, it has been suggested that dietary levels of calcium may enhance its effects on bone mass, particularly with young animals, suggesting a potential role of CLA in bone development (Park, Terk & Park, 2011). When aged animals were tested, CLA supplementation significantly improved bone mass accompanied with reduced bone marrow adiposity and decreased bone resorption (Halade, Rahman, Williams & Fernandes, 2011; Park & Park, 2010; Rahman, Halade, Williams & Fernandes, 2011). These results suggest that CLA not only influences bone formation consistent with our current results, but also influences bone resorption.…”

Section: Discussionmentioning

confidence: 99%

trans-10,cis-12 CLA promotes osteoblastogenesis via SMAD mediated mechanism in bone marrow mesenchymal stem cells

Kim

Park

2014

Journal of Functional Foods

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The inverse relationship between osteoblast and adipocyte differentiation in bone marrow mesenchymal stem cells has been linked to overall bone mass. It has previously been reported that conjugated linoleic acid (CLA) inhibits adipogenesis via a peroxisome-proliferator activated receptor-γ (PPARγ) mediated mechanism, while it increases osteoblastogenesis via a PPARγ-independent mechanism in mesenchymal stem cells. This suggests potential implication of CLA on improving bone mass. Thus the purpose of this study was to determine involvement of CLA on regulation of osteoblastogenesis in murine mesenchymal stem cells by focusing on the Mothers against decapentaplegic (MAD)-related family of molecules 8 (SMAD8), one of key regulators of osteoblastogenesis. The trans-10,cis-12 CLA, but not the cis-9,trans-11, significantly increased osteoblastogenesis via SMAD8, and inhibited adipogenesis independent of SMAD8, while inhibiting factors regulating osteoclastogenesis in this model. These suggest that CLA may help improve osteoblastogenesis via a SMAD8 mediated mechanism.

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“…The relationship between chemical structure and activity postulates a system of conjugated double bonds required for the biological function of CLA isomers. This assumption was already validated in vitro for long‐chain conjugated fatty acids with 19, 20, and 22 carbons of synthetic origin . As so, one can speculate that the unexploited t 8, c 10 CLA isomer may also display anti‐adipogenic properties.…”

Section: Introductionmentioning

confidence: 68%

Novel anti‐adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3‐L1 adipocytes

Martins

Pires

Madeira

et al. 2016

Euro J Lipid Sci & Tech

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In this study, we hypothesized that trans(t)8,cis(c)10 conjugated linoleic acid (CLA) isomer possesses anti-adipogenic properties in resemblance to its structural analog, the t10,c12 CLA isomer. After chemical synthesis and purification of the t8,c10 CLA isomer in our laboratory, we report, for the first time, its individual action on the lipid metabolism of 3T3-L1 adipocytes. Cells were supplemented with 50 mM of linoleic acid (LA), t10,c12, or t8,c10 during 11 days of differentiation. Intracellular triacylglycerols (TAG) content was affected by fatty acid treatments. The t8,c10 CLA isomer reduced TAG content but in a lower magnitude, three times less, than the t10,c12 isomer. The supplementation with LA increased TAG storage thus reversing CLA isomers effect. The fatty acid profile of treated adipocytes showed that the t8,c10 CLA isomer incorporation was identical to the t10,c12. The mRNA expression of several genes involved in lipogenesis, lipolysis, fatty acid b-oxidation, and adipocytes differentiation underlying anti-adipogenic action was determined. The t10,c12 CLA isomer decreased gene expression levels related to lipogenesis but did not up-regulate HSL and PPARA associated with lipolysis and fatty acid b-oxidation, respectively. The t8,c10 CLA isomer increased SCD mRNA level without affecting delta 9 desaturase index-16, an indicator of SCD enzyme activity. Taken together, our results indicate that the t8,c10 CLA isomer, tested individually on lipid metabolism of 3T3-L1 adipocytes, is anti-adipogenic.Practical applications: New and more effective weight loss supplements are widely pursued facing the worldwide obesity epidemic. Over the last few decades, the anti-adipogenic properties of conjugated linoleic acid (CLA) have been studied and confirmed for the t10,c12 CLA isomer but, until now, there was no information on its structural analog, the t8,c10. This study provides novel insights on the putative anti-adipogenic ability of the t8,c10 CLA isomer exploiting potential molecular mechanisms of action in 3T3-L1 adipocytes.

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Conjugated nonadecadienoic acid is more potent than conjugated linoleic acid on body fat reduction

Cited by 20 publications

References 61 publications

Conjugated linoleic acid (CLA) influences muscle metabolism via stimulating mitochondrial biogenesis signaling in adult‐onset inactivity induced obese mice

Conjugated linoleic acid (CLA) influences muscle metabolism via stimulating mitochondrial biogenesis signaling in adult‐onset inactivity induced obese mice

trans-10,cis-12 CLA promotes osteoblastogenesis via SMAD mediated mechanism in bone marrow mesenchymal stem cells

Novel anti‐adipogenic properties of the individual trans8,cis10 conjugated linoleic acid (CLA) isomer in 3T3‐L1 adipocytes

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