Conjugated polymer nanomaterials for theranostics

Qian, Chenggen; Chen, Yulei; Feng, Peijian; Xiao, Xuanzhong; Dong, Mei; Yu, Jicheng; Hu, Quanyin; Shen, Qun; Gu, Zhen

doi:10.1038/aps.2017.42

Cited by 99 publications

(59 citation statements)

References 132 publications

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“…Nanoparticles that can absorb and/or transfer light energy and generate ROS by themselves after irradiation activation include TiO2 nanoparticles (Rengeng et al 2017), quantum dots (Chatterjee et al 2008), silicon nanoparticles (Agostinis et al 2011), silica nanoparticles (Kim et al 2017;W. H. Chen et al 2017) and conjugated polymer nanoparticles (Qian et al 2017), etc. Nanoparticles are also promising carriers for PSs, as they can be designed to provide excellent biocompatibility, improve the stability, increase the efficiency of delivery to targeted tissues, overcome the blood-brain barrier (BBB) (Dixit et al 2015) or cell-membrane transporters (Roh et al 2017), and to enhance the generation of singlet oxygen by PSs.…”

Section: Nano-sensitisersmentioning

confidence: 99%

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

He¹,

Liu²,

Byrne³

et al. 2019

Applications of Targeted Nano Drugs and Delivery Systems

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Pharmaceuticals, and more recently biopharmaceuticals, have become the mainstay for antineoplastic treatments in combination with surgical interventions and radiation therapy. In recent years, advances have been made in the development of nanotechnological interventions for the treatment of cancer alone or in combination with existing therapeutic modalities. Nanotechnology used for therapeutic drug delivery and sensitization of photodynamic, sonodynamic and radiotherapy are now being tested in preclinical and clinical trials for the treatment of cancer. This article will review the current state of the art for nanotechnology therapies with an emphasis on targeted drug delivery and the observed and likely benefits when used in combination with existing therapeutic approaches.

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Section: Nano-sensitisersmentioning

confidence: 99%

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

He¹,

Liu²,

Byrne³

et al. 2019

Applications of Targeted Nano Drugs and Delivery Systems

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“…Actually, water‐soluble SPs were already prepared by introducing highly charged groups (e.g., –COO − , SO 3 − , –NR 3 + ) in the side chains, however, the synthesis was still complicated and these groups may exhibit strong interactions toward biomolecules. [ 32 ] Besides, the conformation and optical property of these charged SPs may change under biological microenvironment due to the variation of temperature and pH values. Therefore, the use of water‐soluble SPs for bioimaging was limited especially for in vivo applications.…”

Section: Introductionmentioning

confidence: 99%

A General Strategy to Encapsulate Semiconducting Polymers within PEGylated Mesoporous Silica Nanoparticles for Optical Imaging and Drug Delivery

Chen

Gong

et al. 2020

Part & Part Syst Charact

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Although semiconducting polymers (SPs) have become an important category for optical imaging and phototherapy, their biomedical application is still facing a number of challenges. Herein, a cationic surfactant–assisted approach to encapsulate hydrophobic SPs within highly PEGylated mesoporous silica (mSiO2) nanoparticles with excellent colloidal stability and enhanced fluorescence in aqueous solution is reported. In comparison to the previously reported amphiphilic polymer coating and silification method, this universal strategy not only suppresses the formation of empty polymer micelles and free silica nanoparticles, but also provides high specific surface area for drug loading. As a proof of concept, furan‐containing diketopyrrolopyrrole‐based semiconducting polymers (PDFT) are coated with mesoporous silica and utilized for fluorescence imaging in the second near‐infrared region (NIR‐II, 1000–1700 nm) and drug delivery. In vivo blood vessel imaging and tumor imaging are achieved with high resolution (0.21 mm) and signal‐to‐background ratio (≈4.2). Additionally, pH‐responsive drug release and improved therapeutic effect are observed. By choosing desired SPs, different optical imaging and therapeutic modalities can also be achieved, thus the SP@mSiO2 nanostructures obtained here provide numerous opportunities for theranostic applications.

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“…While OEM-based nanoparticles have promise for simultaneous imaging and drug delivery (i.e., theranostic applications) [ 18 , 19 ], nanoparticles are not the only morphology of materials that OEMs can be processed into, and it is also possible to manufacture OEM-based films, fibers, foams, and hydrogels [ 20 , 21 , 22 , 23 , 24 ]. The morphologies of these alternative materials are under investigation for their inclusion into new versions of a variety of clinically translated electronic interfaces for the body (e.g., cardiac pacemakers, cochlear implants, retinal prostheses, and electrodes for deep brain stimulation), or indeed, electronic interfaces for the peripheral nervous system (e.g., for the control of the bladder) [ 20 , 21 , 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

et al. 2018

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The delivery of drugs in a controllable fashion is a topic of intense research activity in both academia and industry because of its impact in healthcare. Implantable electronic interfaces for the body have great potential for positive economic, health, and societal impacts; however, the implantation of such interfaces results in inflammatory responses due to a mechanical mismatch between the inorganic substrate and soft tissue, and also results in the potential for microbial infection during complex surgical procedures. Here, we report the use of conducting polypyrrole (PPY)-based coatings loaded with clinically relevant drugs (either an anti-inflammatory, dexamethasone phosphate (DMP), or an antibiotic, meropenem (MER)). The films were characterized and were shown to enhance the delivery of the drugs upon the application of an electrochemical stimulus in vitro, by circa (ca.) 10–30% relative to the passive release from non-stimulated samples. Interestingly, the loading and release of the drugs was correlated with the physical descriptors of the drugs. In the long term, such materials have the potential for application to the surfaces of medical devices to diminish adverse reactions to their implantation in vivo.

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Conjugated polymer nanomaterials for theranostics

Cited by 99 publications

References 132 publications

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

Combination Strategies for Targeted Delivery of Nanoparticles for Cancer Therapy

A General Strategy to Encapsulate Semiconducting Polymers within PEGylated Mesoporous Silica Nanoparticles for Optical Imaging and Drug Delivery

Electrochemically Enhanced Drug Delivery Using Polypyrrole Films

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