1988
DOI: 10.1159/000457695
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Conjugation of Styrene Oxide by the Basic and Acidic Forms of Glutathione Transferase in the Human Fetal Liver

Abstract: Two forms of glutathione transferase were isolated by means of isoelectric focusing of human fetal liver cytosol preparations. The enzyme activity was measured with l-chloro-2,4-dinitrobenzene as the electrophilic substrate. One peak focused at pH 9-10 (basic form) and the other at pH 4-5 (acidic form). The basic and the acidic forms are representatives of glutathione transferase classes a and n, respectively. These classes constitute two of the three classes defined for cytosolic forms of the enzyme in severa… Show more

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Cited by 5 publications
(2 citation statements)
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“…Thus the fetal GT differs from the adult enzyme both qualitatively and quantitatively. A similar conclusion was obtained with the gluta thione transferase(s) that has a different isoenzyme composition in fetal and adult liver [14].…”
Section: Discussionsupporting
confidence: 81%
“…Thus the fetal GT differs from the adult enzyme both qualitatively and quantitatively. A similar conclusion was obtained with the gluta thione transferase(s) that has a different isoenzyme composition in fetal and adult liver [14].…”
Section: Discussionsupporting
confidence: 81%
“…Several alternative first noncoding exons have been identified, whereas one is predominantly expressed in the liver [10,11]. The ontogeny expression of MGST1 in humans has never been studied, but it is well known that cytosolic GSTs are functional in various human fetal tissues [12–14].…”
Section: Introductionmentioning
confidence: 99%