Conjugation of triphenylantimony(V) with carvacrol against human breast cancer cells

Porcupine quills keratin peptides induces G0/G1 cell cycle arrest and apoptosis via p53/p21 pathway and caspase cascade reaction in MCF‐7 breast cancer cells

“…The ability of PQKPs to induce apoptosis in MCF‐7 cells was also verified by AO/EB staining of nuclear DNA in live and dead MCF‐7 cells. According to the morphological characteristics of stained cell nuclei, MCF‐7 cells can be classified into four types: viable cells (uniformly green), early apoptotic cells (greenish yellow or green yellow fragments), late apoptotic cells (orange or orange fragments) and necrotic cells (uniformly red fluorescing and swollen) 31 . MCF‐7 cells in the control group showed a uniform green color nucleus with organized structures (Fig.…”

“…2 (greenish yellow or green yellow fragments), late apoptotic cells (orange or orange fragments) and necrotic cells (uniformly red fluorescing and swollen). 31 MCF-7 cells in the control group showed a uniform green color nucleus with organized structures (Fig. 2(C)).…”

A Water‐Soluble Antimony‐Rich Polyoxometalate with Broad‐Spectrum Antitumor Activities

“…Antimony, one heavy pnictogen, has been medicinally used for over 100 years [7] . Due to the stereo activity of the lone electron‐pair, Sb‐complexes can target protein tyrosine phosphatases and increase the generation of reactive oxygen species, leading to the apoptosis of cancer cells [8] …”

“…[7] Due to the stereo activity of the lone electron-pair, Sb-complexes can target protein tyrosine phosphatases and increase the generation of reactive oxygen species, leading to the apoptosis of cancer cells. [8] Recently, the introduction of Sb ions into POMs creating Sb-containing POMs has attracted increasing attention, because such composite POMs synergize the advantages of POMs and Sb, and thus become promising antitumor agents. [9] For example, {Co 4 Sb 9 W 24 }, [10] {Na 0.7 M 5.3 Sb 2 W 18 } (M = Ni/Co), [11] and {SbW 8 O 30 } [12] are reported to exhibit excellent antitumor activities.…”

Binuclear Triphenylantimony(V) Catecholates through N-Donor Linkers: Structural Features and Redox Properties

“…Organoantimonials represent a very diverse class of antimony compounds, attracting growing attention from scientists because of the variety of structural motifs offered by this type compounds (including acting as ligands in different complexes) [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ], various and sometimes unusual reactivity [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ], and prospective applications in biochemistry and medicine [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. So, some tetraarylstibonium cations, as well as cationic stibine–palladium complexes, may be used as sensors for the toxic fluoride anion, even in water [ 31 , 32 , 33 , 34 ], can activate the Element–Fluorine bond and promote the hydrodefluorination of fluoroalkanes in the presence of Et 3 SiH [ 35 ], or activate the Ag–Cl bond in gold chloride complex to catalyze the cyclization of propargyl amides [ 36 ].…”