Conjunctival allergic contact hypersensitivity

Almeida, L.; Ortega, Natividad; Dumpiérrez, Antonio G.; Castillo, R.; Blanco, Carlos; Navarro, Laia; Carrillo, Teresa

doi:10.1034/j.1398-9995.2001.056008785.x

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…The chronic inflammatory response which is associated with a predominance of T-cells suggests that the described alterations may have been caused by a late onset immunoreaction to phenylephrine or another component of the galenic formulation. Previous reports have described such a delayed cell-mediated hypersensitivity to phenylephrine, which could be confirmed by epicutane patch testing (3). Alternatively, a direct sympathomimetic effect may have been causally involved.…”

Section: Discussionmentioning

confidence: 71%

Abuse of Vasoconstrictive Eyedrops Mimicking an Ocular Pemphigoid

Tappeiner

Abegg

2009

European Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 71%

Abuse of Vasoconstrictive Eyedrops Mimicking an Ocular Pemphigoid

Tappeiner

Abegg

2009

European Journal of Ophthalmology

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“…In these circumstances, the evaluation of the risk/benefit ratio of intravenous phenylephrine administration should probably be taken into consideration, as there is a risk that patients may develop a generalized eczema if phenylephrine is injected intravenously (13, 14). Therefore, it would be prudent to replace phenylephrine with another vasopressor in these cases, as cross‐reactivity with closely related and structurally similar drugs, such as epinephrine and ephedrine, has not been established (5, 15).…”

Section: Discussionmentioning

confidence: 99%

Anaesthetists should be aware of delayed hypersensitivity to phenylephrine

Dewachter

Mouton‐Faivre

2007

Acta Anaesthesiol Scand

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Delayed reactions to phenylephrine, used as a mydriatic agent during ophthalmological surgical procedures, are well known. We diagnosed a delayed hypersensitivity reaction to phenylephrine included in an ophthalmic insert in a woman presenting, 24 h after surgery, with an acute blepharoconjunctivitis associated with eyelid eczema of the operated eye. The diagnosis was supported by the recognition of clinical symptoms associated with a positive patch test to phenylephrine. Patients who present with previous contact eczema to phenylephrine may develop a generalized eczema if phenylephrine is injected intravenously. Intravenous phenylephrine is increasingly being used in the operating room to treat hypotension. This case report confirms the need for systematic allergological investigation of all drugs and substances administered during the peri-operative period in order to avoid a delayed hypersensitivity reaction occurring after the peri-operative period. Anaesthetists should be aware of the possibility of delayed hypersensitivity reactions involving phenylephrine.

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