Conjunctival naloxone is no decision aid in opioid addiction

Loimer, Norbert; Grünberger, J; Linzmayer, L; Schmid, Rainer

doi:10.1016/0140-6736(90)92690-j

Cited by 4 publications

(1 citation statement)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a strategy to reduce BBV transmission, researchers have sought alternative routes for administration of naloxone, in particular non‐invasive methods. Investigation of the oral [53] and conjunctival routes [54] have been unsuccessful. Hussain and colleagues were the first to report investigation of naloxone for i.n.…”

Section: The Evidence Regarding Intranasal Naloxonementioning

confidence: 99%

Intranasal naloxone for the treatment of suspected heroin overdose

2008

View full text Add to dashboard Cite

Currently there is not enough evidence to support i.n. naloxone as first-line intervention by paramedics for treatment of heroin overdose in the pre-hospital setting. Further research is required to confirm its clinical effectiveness, safety and utility. If proved effective, the i.n. route may be useful for drug administration in community settings (including peer-based administration), as it reduces risk of needlestick injury in a population at higher risk of blood-borne viruses. Problematically, naloxone is not manufactured currently in an ideal form for i.n. administration.

show abstract

Section: The Evidence Regarding Intranasal Naloxonementioning

confidence: 99%

Intranasal naloxone for the treatment of suspected heroin overdose

2008

View full text Add to dashboard Cite

show abstract

Nasal administration of naloxone for detection of opiate dependence

Loimer

Hofmann

Chaudhry

1992

Journal of Psychiatric Research

View full text Add to dashboard Cite

The naloxone conjunctival test: an underused tool? A review of the available data

et al. 1997

View full text Add to dashboard Cite

SummaryThere is currently no simple and morbidity-free procedure available to determine opiate dependence in patients. There is preliminary evidence, however, that the naloxone conjunctival test may be useful in this regard. This test consists of instilling a drop of saline solution of naloxone hydrochloride (an opiate-receptor antagonist) into the subject's eye. This causes significant homolateral mydriasis (anisocoria) in the eye of a chronic opioid-dependent subject and not in that of a non-dependent subject. We reviewed the international literature on the naloxone conjunctival test using the Medline database and a manual search of major scientific journals specialized in the field of substance abuse. Up to March 1995, we identified six articles dealing specifically with the use of opiate antagonist ophthalmic solutions in populations of chronic opioid addicts. Four of the articles reported the occurrence of mydriasis when a solution of naloxone is used in opioid addicts. Two of the articles reported that there was no differential change in pupil size when the naloxone solution is used; however, one study used a much weaker and the other a much stronger solution of naloxone than reported in the other studies. From our review of the literature, it appears that the naloxone conjunctival test holds great promise as a simple and morbidity-free method of testing for chronic opioid addiction and, therefore, it should be studied further and its usage eventually developed.

show abstract

Conjunctival naloxone is no decision aid in opioid addiction

Cited by 4 publications

References 3 publications

Intranasal naloxone for the treatment of suspected heroin overdose

Intranasal naloxone for the treatment of suspected heroin overdose

Nasal administration of naloxone for detection of opiate dependence

The naloxone conjunctival test: an underused tool? A review of the available data

Contact Info

Product

Resources

About